Results 91 to 100 of about 16,904 (242)

Effect of tadalafil on erectile dysfunction in male patients with diabetes mellitus [PDF]

, 2007
Background/Aim. During the first 10 years over 50% of diabetes patients develop erectile dysfunction (ED). It is more severe and resistant to therapy than in male patients with normal glucoregulation.
Antonijević Nebojša, Dabetić Marija, Dimitrijević-Srećković Vesna, Gostiljac Draško, Matanović Dragana, Milić Gordana, Nale Đorđe, Nišić Tanja, Popović Srđan, Vujović Svetlana, Đorđević Predrag   +10 more
core   +1 more source

Diketopiperazine-Based, Flexible Tadalafil Analogues: Synthesis, Crystal Structures and Biological Activity Profile

Molecules, 2021
Phosphodiesterase 5 (PDE5) is one of the most extensively studied phosphodiesterases that is highly specific for cyclic-GMP hydrolysis. PDE5 became a target for drug development based on its efficacy for treatment of erectile dysfunction.
Adam Mieczkowski, Elżbieta Speina, D. Trzybiński, M. Winiewska-Szajewska, P. Wińska, Ewelina M Borsuk, M. Podsiadła-Białoskórska, Tomasz Przygodzki, K. Drabikowski, L. Stańczyk, I. Zhukov, C. Watała, K. Woźniak   +12 more
semanticscholar   +1 more source

Uncovering the Key Factors Influencing Phytochemical and Phytopharmacological Properties During Medicinal Plant Processing

eFood, Volume 7, Issue 1, February 2026.
From farm to pharma, this review details the engineering of quality in medicinal plants through a science‐driven approach: it first elucidates how genetic and environmental factors inscribe the plant's phytochemical and phytopharmacological profile before harvest, and then dissects the postharvest techniques and technologies—chemical and thermal pre ...
Elyas Aryakia
wiley   +1 more source

Modulating phosphodiesterase-5 activity to suppress the immunosuppressive mechanisms of myeloid-derived suppressor cells in breast cancer

Breast Cancer Research
Phosphodiesterase-5 (PDE5) inhibitors have been shown to have potential as an adjuvant therapy for cancer. Tadalafil is a potent and selective PDE5 inhibitor that has been shown to inhibit the aggregation of myeloid-derived suppressor cells (MDSC) within
Yingxue Guo, Mengyun Chen, Qi Yuan, Jie Huang, Wen Mao, Xianli Liu, Lu Jin, Lijia Chen, Jingyi Lou, Xia Liu, Qi Pan, Huiying Fu, Qiyang Shou   +12 more
doaj   +1 more source

Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity [PDF]

, 2014
STUDY QUESTION: Can we identify compound(s) with reported phosphodiesterase inhibitor (PDEI) activity that could be added to human spermatozoa in vitro to enhance their motility without compromising other sperm functions?
Alasmari, Alasmari, Baker, Barratt, Baxendale, Bjorndahl, Christopher L.R. Barratt, Comhaire, Conti, Cooper, David, Fisch, Ford, Francis, Glenn, Harrison, HFEA, Horvath, Houslay, Huacuja, Hull, Hunnicutt, Irvine, Ivic, Lefièvre, Lefièvre, Lefièvre, Linda Lefièvre, Lorna Frame, Martin, Mortimer, Mrsny, Nassar, Negri, O'Connell, Oladipo A. Madamidola, Paul G. Wyatt, Publicover, Richter, Sarah J. Martins Da Silva, Sean G. Brown, Sousa, Steve Tardif, Stone, Tesarik, Tomlinson, Tomlinson, Torres-Flores, Tournaye, Tournaye, Van der Steeg, Wang, Yang, Yovich, Yovich   +54 more
core   +5 more sources

Virtual Screening of Phytochemicals From Medicinal Plants as Promising PDE5 Inhibitors Against Erectile Dysfunction

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Phytochemicals from Algerian medicinal plants were virtually screened as potential phosphodiesterase‐5 (PDE5) inhibitors for erectile dysfunction therapy. Drug‐likeness and toxicity analyses identified catechin, ellagic acid, and rosmarinic acid as safe, bioavailable candidates.
Farouk Boudou, Alaeddine Berkane, Amal Belakredar, Ahcene Keziz, Huda Alsaeedi, Brian A. Murray, Mikhael Bechelany, Ahmed Barhoum   +7 more
wiley   +1 more source

Vasa Nervorum in rat major pelvic ganglion are innervated by nitrergic nerve fibers [PDF]

, 2013
INTRODUCTION The vasa nervorum comprises a network of small diameter blood vessels that provide blood supply to nerves and ganglia. The cell bodies of autonomic nerves innervating the urogenital organs are housed in the major pelvic ganglia (MPG) in rats.
Ames, Andersson, Appenzeller, Asif Muneer, Benesova, Benesova, Cameron, Cameron, Cameron, Cellek, Cellek, Cellek, Cellek, Chandrasekharan, Chantrain, Chung, Dail, Dashwood, Dixon, Giuliano, Gonzalez‐Hernandez, Hackett, Hlaing, Iadecola, Kalsi, Karl A. Beetson, Kavdia, Kedia, Kobayashi, Low, Mary A. Cotter, Mbaku, McManis, Melikian, Norman E. Cameron, Padma‐Nathan, Porst, Saenz de Tejada, Schirar, Selim Cellek, Sonntag, Stephanie F. Smith, Stuehr, Tabatai, Toda, Toda, Toda, Toque, Vitullo, Wang   +49 more
core   +1 more source

Toward the harmonization of bioequivalence guidelines in Europe: Commentary on the state of the art and future priorities under ICH M13A for immediate‐release oral forms

British Journal of Clinical Pharmacology, EarlyView.
Domenico Nocera, Giusi Forastiero, Andrea Logreco, Alessia Proietti, Antonio Galluccio, Carlotta Lunghi, Elisabetta Poluzzi, Fabrizio De Ponti   +7 more
wiley   +1 more source

Low‐intensity shockwave therapy for erectile dysfunction due to diabetes mellitus or coronary artery disease: An individual participant data meta‐analysis from a single center

Andrology, Volume 14, Issue 2, Page 348-351, February 2026.
Abstract Background Low‐intensity shockwave therapy (LiST) is a first‐line treatment for vasculogenic erectile dysfunction (ED). However, its efficacy in challenging cases, such as ED solely due to type 2 diabetes mellitus (DM) or coronary artery disease (CAD), has not been adequately assessed.
Nikolaos Pyrgidis, Dimitrios Kalyvianakis, Ioannis Mykoniatis, Dimitrios Hatzichristou   +3 more
wiley   +1 more source

Inibidores da 5-fosfodiesterase no tratamento sintomático da hiperplasia benigna da próstata [PDF]

, 2011
Trabalho final de mestrado integrado em Medicina, área científica de Urologia, apresentado á Faculdade de Medicina da Universidade de CoimbraTanto a hiperplasia benigna da próstata como a disfunção eréctil são patologias com elevada prevalência em ...
Costa, Christine Silva
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