Results 21 to 30 of about 16,904 (242)

The Wound Healing Effect of Nanoclay, Collagen, and Tadalafil in Diabetic Rats: An In Vivo Study

Advances in Materials Science and Engineering, 2022
The diabetic wound is the most challenging one to manage, which is associated with microvascular and macrovascular dysfunction, and novel strategies such as using hydrogels demonstrate their promising prospect in treatment and management approaches of ...
Allahyar Noori Ordeghan, D. Khayatan, Mohammad Reza Saki, Mostafa Alam, Kamyar Abbasi, H. Shirvani, M. Yazdanian, R. Soufdoost, Haidar Taimouri Raad, A. Karami, H. Tebyaniyan   +10 more
semanticscholar   +1 more source

Tadalafil Enhances Immune Signatures in Response to Neoadjuvant Nivolumab in Resectable Head and Neck Squamous Cell Carcinoma

Clinical Cancer Research, 2021
Purpose: We hypothesize that the addition of the phosphodiesterase-5 inhibitor tadalafil to the PD-1 inhibitor nivolumab, is safe and will augment immune-mediated antitumor responses in previously untreated squamous cell carcinoma of the head and neck ...
A. Luginbuhl, J. Johnson, L. Harshyne, A. Linnenbach, S. Shukla, A. Alnemri, G. Kumar, D. Cognetti, J. Curry, N. Kotlov, Zoya Antysheva, Sandrine Degryse, K. Mannion, M. Gibson, J. Netterville, Brandee T. Brown, R. Axelrod, R. Zinner, M. Tuluc, S. Gargano, B. Leiby, A. Shimada, M. Mahoney, U. Martinez-Outschoorn, U. Rodeck, Young J Kim, A. South, A. Argiris   +27 more
semanticscholar   +1 more source

Phosphodiesterase Type 5 Inhibitors, Sport and Doping [PDF]

, 2017
Phosphodiesterase type 5 inhibitors (PDE5i) (e.g., sildenafil, tadalafil, vardenafil, and avanafil) are drugs commonly used to treat erectile dysfunction, pulmonary arterial hypertension, and benign prostatic hyperplasia.
Borrione, Paolo, CECI GALANOS, Roberta, Crescioli, Clara, Di Luigi, Luigi, Duranti, Guglielmo, Sabatini, Stefania, Sansone, Andrea, Sansone, Massimiliano, Sgrò, Paolo   +8 more
core   +1 more source

Effect of Ticagrelor, a Cytochrome P450 3A4 Inhibitor, on the Pharmacokinetics of Tadalafil in Rats

Pharmaceutics, 2019
Tadalafil is a cytochrome P450 (CYP) 3A4 substrate. Because there are few data on drug-drug interactions, it is advisable to take sufficient consideration when co-administering tadalafil with CYP3A4 inducers or inhibitors.
Young-Guk Na, Jin-Ju Byeon, Hyun Wook Huh, Min-Ki Kim, Young G. Shin, Hong-Ki Lee, Cheong-Weon Cho   +6 more
doaj   +1 more source

Effects of phosphodiesterase V inhibition alone and in combination with BNP on cardiovascular and renal response to volume load in human preclinical diastolic dysfunction

Physiological Reports, 2021
Preclinical diastolic dysfunction (PDD) results in impaired cardiorenal response to volume load (VL) which may contribute to the progression to clinical heart failure with preserved ejection fraction (HFpEF).
Siu‐Hin Wan, Paul M. McKie, Joshua P. Slusser, John C. Burnett Jr, David O. Hodge, Horng H. Chen   +5 more
doaj   +1 more source

Erectile dysfunction - an update of current practice and future strategies [PDF]

, 2013
Erectile dysfunction (ED) is defined as the inability to achieve and maintain a penile erection adequate for satisfactory sexual intercourse.1 Up to 150 million men worldwide suffer from ED and this figure is likely to double by the year 2025.2 A number
Kalsi, J, Muneer, A
core   +1 more source

Prospective comparison of tadalafil 5 mg alone, silodosin 8 mg alone, and the combination of both in treatment of lower urinary tract symptoms related to benign prostatic hyperplasia

World journal of urology, 2022
Men with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH), will have deterioration in the quality of life. Likewise, BPH can be complicated by damage to bladder function, bladder stones formation, hematuria, and ...
M. AbdelRazek, A. Abolyosr, Omar Mhammed, A. Fathi, Mohammed M. Talaat, A. Hassan   +5 more
semanticscholar   +1 more source

Tadalafil improves lean mass and endothelial function in nonobese men with mild ED/LUTS: in vivo and in vitro characterization [PDF]

, 2017
PURPOSE: Phosphodiesterase type-5 inhibitor administration in diabetic men with erectile dysfunction (ED) is associated with reduced waist circumference.
Aversa, Antonio, Bimonte, VIVIANA MARIA, Crescioli, Clara, Di Luigi, Luigi, Fittipaldi, Simona, Francomano, Davide, Greco, Emanuela A., Lenzi, Andrea, Migliaccio, Silvia   +8 more
core   +1 more source

Correcting imbalance of sex hormones by a phosphodiesterase 5 inhibitor improves copulatory dysfunction in male rats with type 2 diabetes

BMJ Open Diabetes Research & Care, 2020
Introduction Sexual dysfunction is a common complication in men with type 2 diabetes and is often refractory to treatment. This study investigated the long-term influence of the phosphodiesterase 5 inhibitor (PDE5I) tadalafil on the level of sex hormones
Akiko Itoga, Xinmin Zha, Keiko Nagase, Yoshitaka Aoki, Hideaki Ito, Osamu Yokoyama   +5 more
doaj   +1 more source

A phosphodiesterase 5 inhibitor, tadalafil, suppresses stromal predominance and inflammation in a rat model of nonbacterial prostatitis

BMC Urology, 2019
Background Chronic inflammation is thought to be a major causative factor for the development of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Tadalafil, a phosphodiesterase type 5 inhibitor (PDE5-I), which has been used for
Mikio Sugimoto, Xia Zhang, Nobufumi Ueda, Hiroyuki Tsunemori, Rikiya Taoka, Yusi Hayashida, Hiromi Hirama, Yasuyuki Miyauchi, Yuki Matsuoka, Hirohito Naito, Yu Osaki, Yosiyuki Kekehi   +11 more
doaj   +1 more source