Jurnal Urologi Indonesia, 2017 Purpose: Assess the efficacy of combined α1-adrenergic blocker (tamsulosin 0,4 mg) and PDE5 inhibitor (tadalafil 5 mg) therapy compared to tadalafil or tamsulosin alone in treating patient BPH with LUTS and ED.
Muhammad Ridha +2 more
doaj +1 more source
Erectile dysfunction and its management in patients with diabetes mellitus [PDF]
, 2015 Diabetes can be described as a syndrome of multiple closely related conditions induced by a chronic state of hyperglycaemia resulting from defective insulin secretion, insulin action or both.
DEFEUDIS, GIUSEPPE +7 more
core +1 more source
Identifcation of small molecule enzyme inhibitors as broad-spectrum anthelmintics [PDF]
, 2019 Targeting chokepoint enzymes in metabolic pathways has led to new drugs for cancers, autoimmune disorders and infectious diseases. This is also a cornerstone approach for discovery and development of anthelmintics against nematode and flatworm parasites.
Aroian, Raffi V. +10 more
core +3 more sources
Sexual Medicine, 2019 Background: Erectile dysfunction (ED) is highly prevalent in aging men. Tadalafil daily and on-demand are widely used for the treatment of ED. Aim: We performed a meta-analysis to evaluate the efficacy and safety of tadalafil daily compared with ...
Zhongbao Zhou, MM +6 more
doaj +1 more source
Sildenafil dosed concomitantly with bosentan for adult pulmonary arterial hypertension in a randomized controlled trial [PDF]
, 2017 BACKGROUND: Few controlled clinical trials exist to support oral combination therapy in pulmonary arterial hypertension (PAH). METHODS: Patients with PAH (idiopathic [IPAH] or associated with connective tissue disease [APAH-CTD]) taking bosentan (62.5 ...
Dombi, Theresa +4 more
core +1 more source
Frontiers in Pharmacology, 2022 The potential role of tadalafil, a PDE5 inhibitor, in anticancer activity and prolonged survival has been proposed. However, the systematic effects of tadalafil in colorectal cancer were not fully understood.
Pan Zhao +5 more
doaj +1 more source
Testosterone insulin-like effects: an in vitro study on the short-term metabolic effects of testosterone in human skeletal muscle cells [PDF]
, 2017 Testosterone by promoting different metabolic pathways contributes to short-term homeostasis of skeletal muscle, the largest insulin-sensitive tissue and the primary site for insulin-stimulated glucose utilization.
Antinozzi, Cristina +8 more
core +2 more sources
Tadalafil modulates aromatase activity and androgen receptor expression in a human osteoblastic cell in vitro model [PDF]
, 2016 Purpose Phosphodiesterase type-5 inhibitor (PDE5i) tadalafil administration in men with erectile dysfunction is associated with increased testosterone/estradiol ratio, leading to hypothesize a potential increased effect of androgen action on target ...
Aversa, Antonio +8 more
core +1 more source
Tadalafil Promotes the Recovery of Peripheral Neuropathy in Type II Diabetic Mice. [PDF]
PLoS ONE, 2016 We previously demonstrated that treatment of diabetic peripheral neuropathy with the short (4 hours) half-life phosphodiesterase 5 (PDE5) inhibitor, sildenafil, improved functional outcome in diabetic db/db mice.
Lei Wang +7 more
doaj +1 more source
Comparison of efficacy for erectile function and lower urinary tract symptoms of tadalafil 20 mg on-demand and 5 mg once daily in patients with erectile dysfunction [PDF]
, 2012 Aim: To compare the improvement in erectile dysfunction (ED) and lower urinary tract symptoms (LUTS) as well as safety of tadalafil dosed at 20 mg on-demand and 5 mg once daily among ED patients.
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core +1 more source