Results 51 to 60 of about 16,904 (242)

Bioequivalence and food effect of a fixed‐dose combination of macitentan and tadalafil: Adaptive design in the COVID‐19 pandemic

Pharmacology Research & Perspectives, 2021
The COVID‐19 pandemic has forced clinical studies to accommodate imposed limitations. In this study, the bioequivalence part could not be conducted as planned.
Dénes Csonka, Vladislav Fishman, Jaya Natarajan, Hans Stieltjes, Danielle Armas, Victor Dishy, Juan Jose Perez Ruixo   +6 more
doaj   +1 more source

New approaches of morfofunktional pharmacological correction of violations of cardiovascular system in experimental preeclampsia [PDF]

, 2016
Experimental Modeling ADMA-like preeclampsia administration to rats was performed by Nnitro-L-arginine methyl ester, from 14 to 20 days of pregnancy.
Gureev, V. V.
core   +2 more sources

Application of hydrophilic polymers for the preparation of tadalafil solid dispersions: micromeritics properties, release and erectile dysfunction studies in male rats

PeerJ, 2022
The objective of the present study was to improve the dissolution rate and aphrodisiac activity of tadalafil by using hydrophilic polymers. Solid dispersions were prepared by solvent evaporation-Rota evaporator using Koliphore 188, Kollidon® VA64, and ...
M. M. Ahmed, M. Anwer, G. A. Soliman, Mohammed F. Aldawsari, A. Mohammed, Sultan M. Alshehri, M. Ghoneim, Amer S. Alali, A. Alshetaili, Ahmed S Alalaiwe, Sarah I. Bukhari, A. Zafar   +11 more
semanticscholar   +1 more source

New insights into the pathogenesis and treatment of non-viral hepatocellular carcinoma: a balancing act between immunosuppression and immunosurveillance. [PDF]

, 2018
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. HCC initiates as a consequence of chronic liver damage and inflammation caused by hepatitis B and C virus infections, excessive alcohol consumption, or non ...
Karin, Michael
core   +1 more source

Phosphodiesterase type 5 inhibitor tadalafil reduces prostatic fibrosis via MiR-3126-3p/FGF9 axis in benign prostatic hyperplasia

Biology Direct
Myofibroblast buildup and prostatic fibrosis play a crucial role in the development of benign prostatic hyperplasia (BPH). Treatments specifically targeting myofibroblasts could be a promising approach for treating BPH.
Tiewen Li, Yu Zhang, Zeng Zhou, Lvxin Guan, Yichen Zhang, Zhiyuan Zhou, Wenhao Wang, Xuehao Zhou, Di Cui, Chenyi Jiang, Yuan Ruan   +10 more
semanticscholar   +1 more source

HPLC-UV and UPLC-MS/MS methods for the simultaneous analysis of sildenafil, vardenafil, and tadalafil and their counterfeits dapoxetine, paroxetine, citalopram, tramadol, and yohimbine in aphrodisiac products

RSC Advances, 2021
In recent times, the counterfeiting of pharmaceuticals has been considered a serious trouble especially in developing countries that acquire poor inspection programs.
Mohamed A. Abdelshakour, Randa A Abdel Salam, Ghada M. Hadad, D. Abo-elmatty, Eman A. Abdel Hameed   +4 more
semanticscholar   +1 more source

Silodosin oral films: Development, physico-mechanical properties and in vitro dissolution studies in simulated saliva [PDF]

, 2019
Sublingual film dosage forms for drugs used for fast symptomatic treatment have promise because they allow a rapid onset of action. The aim of this study was to prepare films of silodosin intended for sublingual administration for the symptomatic ...
Adair, Alhayali, Allam, Alonzo, Boateng, Brady, Brouwers, Campisi, Chapple, Curatolo, De Caro, El-Setouhy, ElMeshad, Gao, Garsuch, Gittings, Guo, Hanif, Hobbs, Huang, Humphrey, Jug, Kalia, Kapoor, Kim, Koland, Korhonen, Li, Liew, Madhav, Mashru, Matsubara, Miller-Chou, Montorsi, Nagy, Patel, Prabhu, Prasad, Preis, Preis, Preis, Radebaugh, Repka, Rossi, Runja, Sharma, Singh, Singh, Singh, Singh, Slavkova, Tanno, Vila, Visser, Vuddanda, Vuddanda, Yang, Zhang   +57 more
core   +2 more sources

Initial combination therapy of macitentan and tadalafil in pulmonary arterial hypertension

European Respiratory Journal, 2020
Initial combination therapy plays a central role in managing pulmonary arterial hypertension (PAH) [1–4]. Patients with low- or intermediate-risk of 1-year mortality at diagnosis should be treated with initial combination therapy with an endothelin ...
O. Sitbon, V. Cottin, M. Canuet, P. Clerson, V. Gressin, L. Perchenet, L. Bertoletti, H. Bouvaist, F. Picard, G. Prévôt, E. Bergot, G. Simonneau   +11 more
semanticscholar   +1 more source

A new original nutraceutical formulation ameliorates the effect of Tadalafil on clinical score and cGMP accumulation.

Archivio Italiano di Urologia e Andrologia, 2021
OBJECTIVE To assess the efficacy of the combination of Tadalafil 5 mg and nutritional supplements composed by Panax ginseng, Moringa Oleifera and Rutin on erectile function in men with mild and moderate vasculogenic ED.
V. Mirone, L. Napolitano, R. d'Emmanuele di Villa Bianca, E. Mitidieri, R. Sorrentino, A. Vanelli, D. Vanacore, Carlotta Turnaturi, Roberto la Rocca, G. Celentano, D. Arcaniolo, G. Cirino   +11 more
semanticscholar   +1 more source

Health-Care Resource Utilization and Treatment Patterns in Men with Erectile Dysfunction and Benign Prostatic Hyperplasia-Associated Lower Urinary Tract Symptoms in the United States: A Retrospective Database Study

Patient Preference and Adherence, 2023
Irwin Goldstein,1 Tarek Hassan,2 Kelly Zou,3 Victoria Divino,4 Mitch DeKoven,4 Joseph Imperato,3 Vamshi Ruthwik Anupindi,4 Jim Li3 1Department of Sexual Medicine, Alvarado Hospital, San Diego, CA, USA; 2Department of Urology, Viatris Inc, Canonsburg, PA,
Goldstein I, Hassan T, Zou K, Divino V, DeKoven M, Imperato J, Anupindi VR, Li J   +7 more
doaj