Results 61 to 70 of about 16,904 (242)

EFFECTS OF TADALAFIL AND/OR SILYMARIN ON GONADAL FUNCTION IN ADULTS MALE ALBINO RATS [PDF]

Basrah Journal of Veterinary Research, 2018
         Taldalafil is a long acting phosphodiesterase-5 inhibitor  widely used in the treatment of erectile dysfunction.
doaj   +1 more source

Decreased soluble guanylate cyclase contributes to cardiac dysfunction induced by chronic doxorubicin treatment in mice [PDF]

, 2017
Aims: The use of doxorubicin, a potent chemotherapeutic agent, is limited by cardiotoxicity. We tested the hypothesis that decreased soluble guanylate cyclase (sGC) enzyme activity contributes to the development of doxorubicin-induced cardiotoxicity ...
Allen, Kaitlin, Bartunek, Jozef, Beerens, Manu, Bloch, Donald B, Bloch, Kenneth D, Brouckaert, Peter, Buys, Emmanuel S, Caluwe, Ellen, Gillijns, Hilde, Janssens, Stefan P, Nathan, Daniel I, Scherrer-Crosbie, Marielle, Swinnen, Melissa, Tainsh, Robert E, Vandenwijngaert, Sara, Walravens, Ann-Sophie   +15 more
core   +1 more source

Association of Abatacept With Lower Mortality Risk Compared to Rituximab in Rheumatoid Arthritis–Associated Interstitial Lung Disease: An Emulated Target Trial

Arthritis &Rheumatology, EarlyView.
Objective The optimal treatment strategy for rheumatoid arthritis–associated interstitial lung disease (RA‐ILD) remains uncertain, and direct comparative data between biologics are limited. This study aimed to evaluate the effectiveness and safety of abatacept compared with rituximab in patients with RA‐ILD.
Po‐Cheng Shih, Shiow‐Ing Wang, Qing‐Wen Wang, James Cheng Chung Wei   +3 more
wiley   +1 more source

Cost effectiveness of first-line oral therapies for pulmonary arterial hypertension: A modelling study [PDF]

, 2016
Background: In recent years, a significant number of costly oral therapies have become available for the treatment of pulmonary arterial hypertension (PAH).
A Drabinski, A Macchia, A Roman, AH Briggs, AJ Peacock, AJ Sutton, AM Keogh, B He, DB Badesch, Doug Coyle, EJ Mills, G Savarese, GE D’Alonzo, GJ Taylor, HA Ghofrani, J Letarte, John Swiston, Julie Blouin, Karen Lee, Kathryn Coyle, Khai Tran, L Guillevin, Lisa Mielniczuk, M Humbert, MC Garin, MD McGoon, Mike Innes, Mohammed F. Jabr, N Galie, N Galie, N Galie, N Galie, O Sitbon, RL Benza, RL Fleurence, RN Channick, SJ Pocock, T Thenappan, TR Einarson, VV McLaughlin, Y Ling, YF Chen, YG Zheng   +42 more
core   +2 more sources

Initial combination therapy of ambrisentan and tadalafil in connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH) in the modified intention-to-treat population of the AMBITION study: post hoc analysis

Annals of the Rheumatic Diseases, 2020
Objectives To evaluate initial combination therapy with ambrisentan plus tadalafil (COMB) compared with monotherapy of either agent (MONO), and the utility of baseline characteristics and risk stratification in predicting outcomes, in patients with ...
M. Kuwana, C. Blair, Tomohiko Takahashi, J. Langley, J. Coghlan   +4 more
semanticscholar   +1 more source

Pulmonary arterial hypertension: the burden of disease and impact on quality of life. [PDF]

, 2015
Pulmonary arterial hypertension (PAH) is a debilitating disease that pervades all aspects of a patients daily life. It is also increasingly acknowledged that the burden of PAH extends to older patients and carers.
Delcroix, M, Howard, L
core   +3 more sources

Cutting edge strategies for diabetic wound care: Nanotechnology, bioengineering, and beyond

BMEMat, EarlyView.
Graphical abstract illustrates the challenges in diabetic wound healing, covering pathophysiology, formulation hurdles, and emerging therapeutic strategies. It highlights the role of hyperglycemia, formulation complexities, and advanced technologies like bioprinting and AI in improving diabetic wound management. Abstract Diabetic wounds affect millions
Usama Ahmad, Wan Nurhidayah Wan Hanaffi, Anas Islam, Aimen Salman, Mohd Muazzam Khan, Faiyaz Shakeel, Qiang Cai, Xiaojun Cai, Quazi T. H. Shubhra   +8 more
wiley   +1 more source

Development of a skeleton-specific antibody and Au nanoparticle-based immunochromatographic sensor for simultaneous detection of various tadalafil adulterants in health food

Food and Agricultural Immunology, 2019
In this work, a rapid, convenient and sensitive Au nanoparticle-based immunochromatographic sensor (AuNPs-ICS) for simultaneous detection of various tadalafil adulterants in health food was established for the first time, based on one high affinity and ...
Fan He, Tingting Zou, Jinyi Yang, Hong Wang, Lihua Deng, Yuanxin Tian, Zhenlin Xu, Yuanming Sun, Hongtao Lei, Xuecai Tan, Yudong Shen   +10 more
doaj   +1 more source

The effect of phosphodiesterase-5 inhibitor, tadalafil, on in vitro potassium chloride-induced contractions of isolated human ureteral tissue

Indian Journal of Urology, 2018
Introduction: Drugs causing ureteral relaxation are used for medical expulsive therapy (MET) for stones. We investigated the in vitro ability of tadalafil to cause relaxation of potassium chloride (KCl)-induced contractions of isolated human ureteral ...
M S Sakthivel, Ratna Prabha, Onkar Singh, Nitin S Kekre, Santosh Kumar   +4 more
doaj   +1 more source

Tadalafil: an overview and the post-mortem toxicology of a case

International Journal of Medical Toxicology and Forensic Medicine, 2023
Tadalafil is an inhibitor of the enzyme human cyclic guanosine monophosphate–specific phosphodiesterase, type 5 (PDE-5). A mild vasodilator, it is primarily used for the treatment of erectile dysfunction (ED), an increasingly common condition.
Maria Laura Schirripa, Letizia Gnetti, Edda Emanuela Guareschi   +2 more
doaj   +1 more source