Results 101 to 110 of about 13,596 (270)

Practical Guidance for the Use of Control‐IQ Technology During Physical Activity and Exercise

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Use of automated insulin delivery (AID) systems during physical activity and exercise (PA) is safe and associated with improved glucose outcomes when compared with insulin pump therapy in manual mode and insulin pen therapy, provided that appropriate adjustments to insulin doses and carbohydrate intake are ensured. Aim This expert
Sergio Di Molfetta, Jonida Haxhi, Francesca Franco, Giuseppe Papa, Andrea Rigamonti, Michael C. Riddell, Dessi P. Zaharieva, Othmar Moser   +7 more
wiley   +1 more source

TOP1MT rs2293925 is an enhancer‐active regulatory SNP that shapes mitochondrial R‐loop dynamics

The FEBS Journal, EarlyView.
This study shows how a common genetic variant of mitochondrial topoisomerase 1 (TOP1MT rs2293925) can influence mitochondrial gene regulation, DNA topology, and formation of noncanonical nucleic acid structures such as R‐loops. By linking this enhancer‐active variant to mitochondrial nucleic acid stress in cellular contexts relevant to amyotrophic ...
Dóra Varga, Zsolt Ráduly, Beáta Boros‐Oláh, Éva Nagy, Zsolt Karányi, László Halász, Bálint László Bálint, György Vámosi, Emese Tóth, Péter Bai, Serena Santangelo, Patrizia Bossolasco, Antonia Ratti, Vincent Géli, Yves Pommier, Lóránt Székvölgyi   +15 more
wiley   +1 more source

Pervasive RNA-binding protein enrichment on TAD boundaries regulates TAD organization

Nucleic Acids Research
Abstract Mammalian genome is hierarchically organized by CTCF and cohesin through loop extrusion mechanism to facilitate the organization of topologically associating domains (TADs). Mounting evidence suggests additional factors/mechanisms exist to orchestrate TAD formation and maintenance.
Qiang Sun, Qin Zhou, Yulong Qiao, Xiaona Chen, Hao Sun, Huating Wang   +5 more
openaire   +2 more sources

Perceptions of the use of the teacher assessment and development system (TADS) for instructional improvement

, 1988
Purpose. The purpose of this study was to examine and compare teacher and administrator perceptions of the use of the Teacher Assessment and Development System (TADS) for instructional improvement in Dade County Public Schools.Procedures.
Annunziata, Joyce
core   +2 more sources

Role of the tomato MARS1/ROUGH gene encoding a LYSINE‐SPECIFIC HISTONE DEMETHYLASE 1 in adventitious root and fruit skin formation

Journal of Integrative Plant Biology, EarlyView.
The tomato mars1/rough mutant displays enhanced root regeneration and rough fruits due to ectopic cell proliferation. The causal gene encodes a lysine‐specific histone demethylase that normally maintains gene silencing. Its loss alters histone methylation, upregulating several genes, including those B‐type cyclins involved in tissue‐specific cellular ...
Eduardo Larriba, Cécile Bres, Aurora Alaguero‐Cordovilla, Riyazuddin Riyazuddin, Qingyi Wang, Johann Petit, Jean‐Philippe Mauxion, Lara Caballero, David Latrasse, Bénédicte Bakan, Rim Brik‐Chaouche, David Esteve‐Bruna, Moussa Benhamed, Christophe Rothan, José Manuel Pérez‐Pérez   +14 more
wiley   +1 more source

The probability of chromatin to be at the nuclear lamina has no systematic effect on its transcription level in fruit flies

Epigenetics & Chromatin
Background Multiple studies have demonstrated a negative correlation between gene expression and positioning of genes at the nuclear envelope (NE) lined by nuclear lamina, but the exact relationship remains unclear, especially in light of the highly ...
Alexander Y. Afanasyev, Yoonjin Kim, Igor S. Tolokh, Igor V. Sharakhov, Alexey V. Onufriev   +4 more
doaj   +1 more source

High‐quality genome of elite peanut cultivar ZH05 reveals subgenome asymmetry, pan‐genome diversity, and breeding insights

Journal of Integrative Plant Biology, EarlyView.
A high‐quality reference genome for the elite peanut cultivar Zhonghua No. 5 revealed differing evolutionary paths between the two peanut subgenomes. SubA has higher overall gene expression and more open chromatin, whereas SubB has stronger structural organization, higher DNA methylation, and greater adaptive diversity associated with peanut evolution ...
Taihua Yang, Nian Liu, Li Huang, Jianbin Guo, Xiaomeng Xue, Mingjun Wang, Xiaohan Zhang, Chengtao Quan, Enyou Feng, Jiazhuang Tan, Zhenzhen Zhang, Yu You, Youlin Xia, Dongxin Huai, Yuning Chen, Liyin Yan, Kede Liu, Huifang Jiang, Yong Lei, Boshou Liao   +19 more
wiley   +1 more source

C‐type cyclin CycC1;1 delays leaf senescence by interacting with and inhibiting MYC2 in Arabidopsis

Journal of Integrative Plant Biology, EarlyView.
The C‐type cyclin CycC1;1 interacts with MYC2 and MED25 to block their association and RNA polymerase II recruitment, thereby repressing senescence‐associated gene expression and delaying leaf senescence in Arabidopsis. Unlike jasmonic acid‐inducible JAZ repressors, CycC1;1 operates independently of jasmonic acid signaling, representing an ...
Cai‐Yi Liao, Xiao‐Li Huang, Lin Li, Guo‐Mao Liu, Kai‐Kai Lu, Hong Yang, Song‐Qi Li, Peng‐Wei Jing, Ru‐Feng Song, Wen‐Cheng Liu   +9 more
wiley   +1 more source

Plant cis‐regulatory grammar: Decoding the multidimensional code of transcriptional regulation for programmable crop engineering

Journal of Integrative Plant Biology, EarlyView.
This review decodes the grammar of plant cis‐regulatory elements, revealing that their function emerges from sequence, chromatin accessibility, 3D topology, and cell type context. It highlights how single‐cell omics, CRISPR dissection, and AI‐driven design converge to enable predictive engineering and crop improvement. ABSTRACT Cis‐regulatory elements (
Libin Zhang, Maoteng Li
wiley   +1 more source

How LLMs might think

Mind &Language, EarlyView.
Do large language models (“LLMs”) think? Daniel Stoljar and Zhihe Vincent Zhang have recently developed an argument from rationality for the claim that LLMs do not think. We contend, however, that the argument from rationality not only falters, but leaves open an intriguing possibility: that LLMs engage only in arational, associative forms of thinking ...
Joseph Gottlieb, Ethan Kemp, Matthew Trager   +2 more
wiley   +1 more source