Results 131 to 140 of about 10,149 (228)

Transboundary Animal Diseases Associated With Cross-Border Camel Movement. A Systematic Review and Meta-Analysis. [PDF]

Transbound Emerg Dis
Adikwu AA, Emeto TI, Horwood PF, Owolodun OA, Adamu AM, Adegboye OA.   +5 more
europepmc   +1 more source

ROWVA: A Structure‐Based Metric for Predicting the Pathogenicity of Protein Variants Using Alphafold2

Cancer Science, Volume 117, Issue 6, Page 1736-1747, June 2026.
This study investigates whether several AF2‐derived scores can predict functional scores and pathogenicity labels, and suggests that the root mean square deviation between the wild‐type and variant structures predicted by AlphaFold2 (ROWVA) may be the most effective predictor. This approach may also be applicable to other multimeric proteins.
Taiki Furutani, Yuka Okusha, Hiroki Nagami, Hiroko Hanafusa, Shuta Tomida, Ryusuke Sawada, Yasuyuki Hosono, Masahiro Nakatochi   +7 more
wiley   +1 more source

TAD boundaries and gene activity are uncoupled. [PDF]

Elife
Almansour F, Fursova NA, Keikhosravi A, Reed KSM, Larson DR, Pegoraro G, Misteli T.   +6 more
europepmc   +1 more source

The NF‐κB Signalling Pathway: Mechanisms, Consequences and Therapeutic Targets

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Nuclear Factor‐kappa B (NF‐κB) is a master transcriptional regulator orchestrating critical cellular processes, predominantly immunity and inflammation. However, its aberrant constitutive activation has emerged as a unifying pathogenetic hallmark across diverse malignancies, autoimmune disorders, and chronic inflammatory diseases.
Bherouz Pourdad, Arash Pourdad
wiley   +1 more source

A low-input Micro-C protocol for high-resolution 3D genome mapping. [PDF]

Biol Methods Protoc
Shan F, Pei C, Xia S, Ling F.
europepmc   +1 more source

PlantCTCIP: Chromatin Interaction Prediction Using Convolutional Neural Network and Transformer in Plants

Plant Biotechnology Journal, Volume 24, Issue 6, Page 3634-3655, June 2026.
ABSTRACT Chromatin interactions establish spatial proximity between distant regulatory elements and their target genes, significantly influencing gene expression, and phenotypic traits. In this study, we present a plant chromatin interaction prediction model called PlantCTCIP based on Convolutional Neural Networks and Transformer.
Zhenye Wang, Siyu Zhou, Ze Guo, Zilan Ning, Jiaqi Cai, Ran Zhao, Ao Xie, Quan Li, Jiangling Zhang, Yongsheng Zhao, Peizhang Li, Haiping Si, Jianbing Yan, Yong Peng, Jianxiao Liu   +14 more
wiley   +1 more source

A wavelet-based approach generates quantitative, scale-free and hierarchical descriptions of 3D genome structures and new biological insights. [PDF]

PLoS Comput Biol
Pellow R, Comeron JM.
europepmc   +1 more source

Chromatin architecture reprogramming reveals novel epigenetic dependencies in breast cancer. [PDF]

Genes Dev
Garcia-Martinez L, Zha M, Borges RL, Liu T, González-Blanco G, Martinez Alonso A, Stransky S, Sidoli S, Zhu H, Wang Z, Morey L.   +10 more
europepmc   +1 more source

Escape from X inactivation varies across genes and tissues and shapes sex-biased sex chromosome gene expression. [PDF]

BMC Genomics
DeCasien AR.
europepmc   +1 more source

HyperDeepTAD: a topologically associated domains detection method based on multiway chromatin interaction data and deep learning. [PDF]

BMC Genomics
Luo J, Liu K, Feng R, Guo F.
europepmc   +1 more source