Results 101 to 110 of about 3,950 (204)
Rapeseed oil-rich diet alters in vitro menadione and nimesulide hepatic mitochondrial toxicity [PDF]
, 2013 Diet-induced changes in the lipid composition of mitochondrial membranes have been shown to influence physiological processes. However, the modulation effect of diet on mitochondrially-active drugs has not yet received the deserved attention.
Jurado, A. S. +3 more
core +1 more source
Kidney Fibrosis In Vitro and In Vivo Models: Path Toward Physiologically Relevant Humanized Models
Advanced Healthcare Materials, Volume 14, Issue 9, April 4, 2025.This review discusses kidney diseases with a focus on kidney fibrosis and the models currently used. It highlights the limitations of animal and 2D in vitro models in replicating human kidney anatomy and physiology. Consequently, there is a significant need for humanized 3D in vitro models, such as 3D cell aggregates, membranes and hydrogels, on‐chip ...
Gabriele Addario +2 more
wiley +1 more source
Loss of tafazzin in yeast leads to increased oxidative stress during respiratory growth [PDF]
Molecular Microbiology, 2008 SummaryThe tafazzin (TAZ) gene is highly conserved from yeast to humans, and the yeast taz1 null mutant shows alterations in cardiolipin (CL) metabolism, mitochondrial dysfunction and stabilization of supercomplexes similar to those found in Barth syndrome, a human disorder resulting from loss of tafazzin.
Shuliang, Chen +2 more
openaire +2 more sources
Advanced Science, Volume 12, Issue 15, April 17, 2025.Targeting USP1 is identified as a strategy that significantly enhances type I IFN‐dependent innate immune response within the TME following radiotherapy. Mechanistically, USP1 inhibition facilitates STING trafficking from ER to Golgi by preserving K27‐linked oligo‐ubiquitination of SAR1A, thereby facilitating efficient activation of the dsDNA‐cGAS ...
Weilin Zhou +15 more
wiley +1 more source
A biophysical approach to large-scale protein-DNA binding data [PDF]
, 2008 About this book * Cutting-edge genome analysis methods from leading bioinformaticians An accurate description of current scientific developments in the field of bioinformatics and computational implementation is presented by research of the BioSapiens ...
Manke, T., Roider, H., Vingron, M.
core +1 more source
A genetic variant in large tumor suppressor kinase 2 of Hippo signaling pathway contributes to prognosis of hepatocellular carcinoma [PDF]
, 2016 published_or_final_versio
Chen, J +9 more
core +1 more source
Frontiers in Genetics, 2016 Mutations in the gene encoding the enzyme tafazzin, TAZ, cause Barth syndrome (BTHS). Individuals with this X-linked multisystem disorder present cardiomyopathy (often dilated), skeletal muscle weakness, neutropenia, growth retardation and 3 ...
Ana eSaric +5 more
doaj +1 more source
Cardiac metabolic pathways affected in the mouse model of barth syndrome. [PDF]
PLoS ONE, 2015 Cardiolipin (CL) is a mitochondrial phospholipid essential for electron transport chain (ETC) integrity. CL-deficiency in humans is caused by mutations in the tafazzin (Taz) gene and results in a multisystem pediatric disorder, Barth syndrome (BTHS).
Yan Huang +9 more
doaj +1 more source
Outlook Magazine, Autumn 2011 [PDF]
, 2011 https://digitalcommons.wustl.edu/outlook/1184/thumbnail ...
core +1 more source
Molecular aspects of WNT/Frizzled signalling in brain angiogenesis [PDF]
, 2017 The family of WNT lipoglycoproteins consists of 19 secreted proteins that are important for multiple cellular processes including cell proliferation, migration and fate.
Hot, Belma
core +1 more source