Results 181 to 190 of about 64,082 (287)

Programmable RNA N6,2´‐O‐Dimethyladenosine Editing

open access: yesAdvanced Science, Volume 13, Issue 29, 22 May 2026.
ABSTRACT N6,2’‐O‐dimethyladenosine (m6Am) is a prevalent RNA modification located at the first transcribed nucleotide adjacent to the 5′ cap of mRNAs, where it has been implicated in gene regulation. However, the lack of methods for precise, transcript‐specific manipulation of m6Am has limited its functional dissection.
Yang Li   +9 more
wiley   +1 more source

Emerging Molecular Antiferroelectrics: Advances and Prospects

open access: yesAdvanced Science, Volume 13, Issue 25, 4 May 2026.
This review focuses on the current research progress in emerging molecular antiferroelectrics, encompassing their diverse structures, antiferroelectricity‐associated properties, and application exploration, including energy storage, electrocaloric refrigeration, and electrostriction.
Xiaoqi Li   +6 more
wiley   +1 more source

Extended π‐Conjugated Bridge Strategy for an Enhanced Stokes Shift and Multimodal Imaging‐Guided Type I/II Photodynamic Therapy Integrated With Photothermal Therapy

open access: yesAggregate, Volume 7, Issue 5, May 2026.
A “unity of a thousand blades” phototheranostic nanoplatform (TDTIC‐M) has been designed to achieve comprehensive theranostic capabilities for breast cancer, including specific subcellular targeting, near‐infrared I/II fluorescence imaging, photoacoustic imaging, photothermal imaging, and multimodal image‐guided synergistic Type I/II photodynamic ...
Chanyuan Jin   +13 more
wiley   +1 more source

Digital seed amplification assay for TDP‐43 aggregate quantification in CSF

open access: yesAlzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Dementia is commonly caused by underlying pathologies driven by misfolded protein aggregates. Although dementia subtypes have distinct mechanisms, overlapping symptoms make diagnosis without biomarkers difficult. Misdiagnosis has previously hindered drug development by enrolling patients non‐specifically in trials.
Ella Borberg   +7 more
wiley   +1 more source

Age‐related behavioral and molecular landmarks in new mouse models for studying Alzheimer's disease in Down syndrome

open access: yesAlzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Down syndrome (DS) is the leading genetic cause of intellectual disability and Alzheimer's disease (AD), with over 90% of individuals developing AD‐related dementia (DSAD). The triplication of the APP gene on chromosome 21 drives early amyloid‐β (Aβ) accumulation, but other Hsa21 genes also contribute to pathology.
Monika Rataj Baniowska   +18 more
wiley   +1 more source

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