Results 31 to 40 of about 7,425,562 (280)
GC-MS profiling and antidepressant-like effect of the extracts of Hamelia patens in animal model
Bangladesh Journal of Pharmacology, 2017 Hamelia patens is used in folk medicine in the treatment of nervous shock. The present study deals to evaluate the antidepressant-like effects of chloroform and methanol extracts of H.
Ajaykumar Rikhabchand Surana +1 more
doaj +1 more source
Active behaviours produced by antidepressants and opioids in the mouse tail suspension test [PDF]
International Journal of Neuropsychopharmacology, 2013 AbstractMost classical preclinical tests to predict antidepressant activity were initially developed to detect compounds that influenced noradrenergic and/or serotonergic activity, in accordance with the monoaminergic hypothesis of depression. However, central opioid systems are also known to influence the pathophysiology of depression.
Esther, Berrocoso +5 more
openaire +2 more sources
Acta Neuropsychiatrica, 2015 ObjectiveTheN-methyl-d-aspartate receptor (NMDAR) antagonist ketamine, produces rapid and enduring antidepressant effect in patients with treatment-resistant depression. Similar dramatic effects have not been observed in clinical trials with other NMDAR antagonists indicating ketamine may possess unique pharmacological properties. Tetrabenazine induces
Skolnica, Phil +3 more
openaire +3 more sources
Evaluation of antidepressant properties of hydroalcoholic extract of Aegle marmelos fruit (Bael fruit) in Swiss albino mice: A pre-clinical study [PDF]
Perspectives In Medical Research, 2023 Introduction: Depression is a prevalent psychiatric disorder affecting 3.8% of the global population. The clinically available antidepressants can cause serious adverse effects. Aegle marmelos fruit has shown a wide range of pharmacological effects.
Shefeek SN +3 more
doaj +1 more source
Indian Journal of Health Sciences and Biomedical Research KLEU, 2016 Objective: Bisphosphonates represent the first choice in the treatment of osteoporosis, and no data are available concerning their effects on comorbid behavior alterations.
N Amitha, S S Torgal
doaj +1 more source
Pharmaceuticals, 2023 Hypothyroidism is closely related to mental disorders, mainly depression, through an as-yet-unknown mechanism. The cerebral inflammatory immune process has been implied to play a pivotal role in the onset of affective symptoms in several conditions.
Yizhen Wang +4 more
doaj +1 more source
α2δ-4 KO mice exhibit diminished depression-like behavior in the tail suspension test.
, 2022 For WT and α2δ-4 KO mice, the duration spent immobile in the tail suspension test (TST) (A-C) and forced swim test (FST, (D-F) was plotted against time (in 1-min bins) during the assay. A and D represent results for males and females combined while B,C,E,
Yoichiro Iwasa (12322774) +7 more
core +1 more source
A study on antidepressant-like effect of dihydroxy flavones in mice and their mechanisms involved
National Journal of Physiology, Pharmacy and Pharmacology, 2018 Background: In the treatment of depression, drugs with a quick onset of action and high margin of safety are intensely being searched. Previous studies indicate flavonoids as a potential source for such drugs.
Nithya Panneerselvam +3 more
doaj +1 more source
Synthesis, in silico analysis and antidepressant activity of 1,3,4-oxadiazole derivatives
Bangladesh Journal of Pharmacology, 2022 The compounds 1,3,4-oxadiazole derivatives (1-8) were synthesized by the cyclization of 4-hydroxy benzhydrazide (1) with various substituted aroma-tic aldehydes (2) using FeCl3 as catalyst and methanol as a solvent medium.
Banylla Felicity Dkhar Gatphoh +4 more
doaj +1 more source
Tail suspension test for depression and anxiety.
, 2013 Tail suspension test (TST) showing immobility periods out of 360 sec total test duration carried out at (A) 1 day; and (B) 28 days after TBI and laser irradiation. Values are in mean ± S.E.M.
Gitika B. Kharkwal (341672) +11 more
core +1 more source