Results 51 to 60 of about 7,425,562 (280)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Modelling generalisation and power dissipation of flexible-wheel suspension concept for planetary surface vehicles [PDF]

, 2011
Flexible-wheel (FW) suspension concept has been regarded to be one of the novel technologies for future planetary surface vehicles (PSVs). This study develops generalised models for fundamental stiffness and damping properties and power consumption ...
Cao, Dongpu, Khajepour, Amir, Song, Xubin   +2 more
core   +5 more sources

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Comparison of blood plasma corticosterone levels in male and female Swiss mice exposed to forced swim test (FST) and tail suspension test (TST).

, 2023
(A) forced swim (FST) and (B) tail suspension (TST) tests. Data are presented as mean ± SEM; * p < 0.05, ** p < 0.01, and *** p < 0.001 compared to sham group of female (proestrus and estrus) or male mice (n = 5), while ## p < 0.01 compared to female ...
Hamilton Barbosa Napolitano (10772454), Luan Silvestro Bianchini Silva (17479007), Iranse Oliveira-Silva (17479016), Gustavo Rodrigues Pedrino (10772466), Elson Alves Costa (8186157), Adesina Paul Arikawe (17479013), Ana Carolina Cavalcante Rodrigues (17478998), Camila Carlos Prado (17479004), Osmar Nascimento Silva (8146974), Rafael Fernandes Costa (17479010), James Oluwagbamigbe Fajemiroye (10772472), Caroline Vitória de Lima Moreira (17479001)   +11 more
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

VEGF Treatment Ameliorates Depression-Like Behavior in Adult Offspring after Maternal Immune Activation

Cells, 2020
Maternal immune activation (MIA) during pregnancy impacts offspring neurodevelopmental trajectories and induces lifelong consequences, including emotional and cognitive alterations.
Spyridon Sideromenos, Claudia Lindtner, Alice Zambon, Orsolya Horvath, Angelika Berger, Daniela D. Pollak   +5 more
doaj   +1 more source

Ovariectomy changes the response to antidepressant drugs in tail suspension test in mice

Gynecological Endocrinology, 2016
Depressive symptoms are very frequent over a lifetime, especially for women. Menopause is a period of higher depressive vulnerability. There are suggestive data that estrogen deficiency may increase the susceptibility for depression. We studied whether a bilateral ovariectomy (OVX) modifies mice behaviors and antidepressant drug effects through tail ...
Yang, Ye, Cunzhi, Liu, Xuewei, Liu, Shuming, Huang   +3 more
openaire   +2 more sources

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source