Results 71 to 80 of about 7,425,562 (280)

Neuropharmacological evaluation of methanolic extract of Costus speciosus Linn. rhizome in Swiss albino mice

Asian Pacific Journal of Tropical Biomedicine, 2019
Objective: To evaluate the neuropharmacological properties of Costus speciosus (C. speciosus) rhizome using different experimental mouse models. Methods: The anxiolytic effect was investigated by hole-board test, elevated plus maze and light/dark test ...
Umay Chen, Md. Saddam Hussain, Tanoy Mazumder, S M Naim Uddin, Sujan Banik   +4 more
doaj   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

A Study of the Effects of 3,5-Diiodo-L-Thyronine in the Tail Suspension and Forced Swim Models of Depression

Brain Science Advances, 2016
Objectives Recent findings have further highlighted the role of the thyroid system in the pathophysiology of depression and revealed new physiologically relevant elements of the thyroid system. Our previous study showed an antidepressant-like effect of 3,
Nataliia Markova, Anton Chernopiatko, Asian Kubatiev, Sergey Bachurin, Harry M. W. Steinbusch, Tatyana Strekalova   +5 more
doaj   +1 more source

Effects of interleukin-1 and endotoxin in the forced swim and tail suspension tests in mice [PDF]

Pharmacology Biochemistry and Behavior, 2005
Male CD-1 mice were administered interleukin-1beta (IL-1beta) and bacterial endotoxin (lipopolysaccharide, LPS) and subsequently tested in the tail suspension test (TST), the Porsolt forced swim test (FST), and in the open field. IL-1beta (100, 300 and 1000 ng/mouse) injected intraperitoneally (i.p.) 90 min before the test induced a dose-dependent ...
Adrian J, Dunn, Artur H, Swiergiel
openaire   +2 more sources

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Antidepressant-like effect of picralima nitida total crude alkaloidal fraction in mice

Scientific African
In 2019, WHO, reported that an estimate of 350 million people globally have depression. Despite the advances made in current pharmacotherapy, about 30–40 % of patients receive insufficient treatment because of the increased occurrence of partial or non ...
Prince Dagadu Okyere, Christian Chukwuma Ndu, Donatus Wewura Adongo, Charles Kwaku Benneh, Eric Woode, Edmund Ekuadzi, Wonder Kofi Mensah Abotsi, Eric Boakye-Gyasi, Priscilla Kolibea Mante   +8 more
doaj   +1 more source

Synthesis of Novel Benzazole Derivatives and Evaluation of Their Antidepressant-Like Activities with Possible Underlying Mechanisms

Molecules, 2018
Novel benzazole derivative compounds 4a⁻4h were obtained by the reaction of corresponding 2-(benzazol-2-ylthio)acetohydrazide and appropriate 4-substituted benzaldehydes. The chemical structures of the synthesized compounds were elucidated by FT-IR,
Gamze Tokgöz, Ümide Demir Özkay, Derya Osmaniye, Nazlı Turan Yücel, Özgür Devrim Can, Zafer Asım Kaplancıklı   +5 more
doaj   +1 more source

Comparative Evaluation of Forced Swim Test and Tail Suspension Test as Models of Negative Symptom of Schizophrenia in Rodents [PDF]

, 2012
Previous studies have shown that the administration of NMDA antagonist can induce negative symptoms of schizophrenia which can be tested through the enhanced immobility observed in the forced swim test (FST).
Manavi Chatterjee, Gautam Palit, Manoj Jaiswal   +2 more
core   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

EFEK MINYAK ATSIRI DAUN KEMANGI (OCIMUM BASILICUM) SEBAGAI ANTIDEPRESAN PADA MENCIT BALB/C DITINJAU DARI IMMOBILITY TIME PADA TAIL SUSPENSION TEST [PDF]

, 2010
Background: The use of medicinal plants is growing widely in the community, one of which is basil (Ocimum basilicum). This plant is believed to have various properties, one of them as an antidepressant.
Insani, Rr. Lely
core   +1 more source