Results 41 to 50 of about 703,333 (283)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

The Impact of Artificial Intelligence on Sustainable Building Technologies [PDF]

E3S Web of Conferences
With the rapid development of artificial intelligence, the demand of urban development for talents with relevant technical and theoretical knowledge is constantly increasing, which is of great significance for the promotion of scientific and ...
Lin Ji, Abdrasulov Sovetbek Misirkulovich, Yuhao Zhao, Shaiyldaeva Asel   +3 more
doaj   +1 more source

What are the Best Practices for Talent Planning? [PDF]

, 2014
As part of business strategy planning, talent planning plays an essential role in positioning a company to maximize the effectiveness of talents and gain competitive advantages. Talent planning can be viewed much broader than succession planning.
Chow, Joy
core   +1 more source

The role of perceived self-efficacy in the development of musical ability: what can the study of successful musicians tell us about teaching music to able children?

, 2011
The role of perceived self-efficacy is important to human social development and to learning in general, but how it relates to music talent development is not well understood.
Areglado R.J., Bandura A., Creech A., Dweck C.S., Good C., Renzulli J.S., Sloboda J.A.   +6 more
core   +1 more source

Accelerated Development of Organizational Talent [PDF]

, 2007
This working paper explores the challenges of accelerated development of organizational talent. The meaning of the word 'accelerated' is that such development takes place at a pace that is significantly higher than that of 'traditional' development that ...
Korotov, Konstantin
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Credit Constraints, Entrepreneurial Talent, and Economic Development [PDF]

In this paper, we formalize the view that economic development requires high rates of productive entrepreneurship, and this requires an efficient matching between entrepreneurial talent and production echnologies.
Bianchi, Milo
core   +3 more sources

Knowledge Spillover Agents and Regional Development [PDF]

, 2007
It is widely recognised that knowledge and highly skilled individuals as "carriers" of knowledge (i.e. knowledge spillover agents) play a key role in impelling the development and growth of cities and regions.
Maier, Gunther, Trippl, Michaela
core  

Sibling interaction as a facilitator for talent development in sport [PDF]

, 2017
While current research has begun to address parental influences on talent development in sport, sibling interaction remains relatively under-examined. Therefore, this study aimed to explore the underpinning mechanisms through which sibling interaction ...
Abbott A, Bernet R, Bloom BS, Bowen M, Côté J, Dave Collins, Dunn J, Greendorfer SL, Haggan P, Howie J Carson, King N, Minuchin S, Partridge J, Richter M, Robin D Taylor, Sarkar M, Smith JA, Smith JA   +17 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source