Results 61 to 70 of about 15,008,175 (252)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Talent identification and development: an academic review. [PDF]

, 2002
The Academic Review was commissioned to help evaluate Sportscotland's pilot Talent Identification and Development Programme which operated from early 2000 to the end of 2001.
Sowerby, Katie, Collins, Dave, Abbott, Angela, Martindale, Russell J J   +3 more
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

What motivates students to participate in honors programs: A fine-grained exploration of honors students’ motivational profiles in the Netherlands

Social Sciences and Humanities Open
Honors programs are extracurricular programs designed to provide talented and ambitious students with academic challenges beyond the standard curriculum.
Berber D. Roorda, Annegien Langeloo, Jorien Vugteveen, Elanor Kamans, Esther T. Canrinus   +4 more
doaj   +1 more source

Building an Scientific and Technological Talent Database for New Quality Productive Forces [PDF]

Nongye tushu qingbao xuebao
[Purpose/Significance] Talent data have become the most important production factor and strategic resource. Building a scientific and technological (S&T) talent database has become an inevitable way to narrow the digital divide and accelerate the
LI Mengli, WANG Ying, QIAN Li, XIE Jing, CHANG Zhijun, JIA Haiqing
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Student achievement prediction and auxiliary improvement method based on fuzzy decision support system

Discover Artificial Intelligence
This paper proposes a student achievement prediction model based on fuzzy decision support system (FDSS), which uses multi-dimensional data to accurately predict student achievement. A prediction model including students’ historical achievement, learning
Xiaoqian Li
doaj   +1 more source

Effect of Different Temperature and Preservation Method on Postharvest Preservation of Tricholoma matsutake

Shipin gongye ke-ji
Tricholoma matsutake was known for its high value. However, it was essential to maintain the quality of Tricholoma matsutake and extend its storage period due to its seasonality, difficulty in harvesting and short shelf life.
Hongwei YAO, Yuexin ZHANG, Yanju WANG, Jingchen SUN   +3 more
doaj   +1 more source