Results 51 to 60 of about 120,245 (308)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A Capability Approach to talent management
, 2013 This paper takes a fresh and radical look at organisational talent management strategies. It offers a critique of some of the prevalent assumptions underpinning certain talent management practices, in particular those fuelled by the narratives of ...
Downs, Yvonne, Swailes, Stephen
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
The Impact of Artificial Intelligence on Sustainable Building Technologies [PDF]
E3S Web of ConferencesWith the rapid development of artificial intelligence, the demand of urban development for talents with relevant technical and theoretical knowledge is constantly increasing, which is of great significance for the promotion of scientific and ...
Lin Ji +3 more
doaj +1 more source
Identifying the Components of the Talent Management of faculty Members in Universities of Medical Sciences: A Meta-synthetic Study [PDF]
مجله ایرانی آموزش در علوم پزشکی, 2021 Introduction: Talent management, especially in higher education, is important due to the main role it can play in tackling the global challenges and development of different countries. This study endeavored to identify the components of talent management
ٍElham keykha, Ahmad keykha
doaj
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Talent identification and development: an academic review. [PDF]
, 2002 The Academic Review was commissioned to help evaluate Sportscotland's pilot Talent Identification and Development Programme which operated from early 2000 to the end of 2001.
Sowerby, Katie +3 more
core
, 2013 Knowing where sports talent is produced is fundamental to identifying spatial factors in talent production and to assist with talent identification. This research develops spatial analysis methods-the 'Talent Tracker'-to harness geographical information ...
Burke, Matthew, Woolcock Geoffrey
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source