Results 41 to 50 of about 712,119 (301)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Exploring British adolescent rugby league players' experiences of professional academies and dropout. [PDF]
, 2018 The purposes of this study were threefold: to explore former rugby league players’ experiences of professional academy environments, to understand their reasons for dropping out of the sport, and to explore their recommendations for optimising future ...
Araujo D. +8 more
core +1 more source
Introducing a Talent Management Model based on Grounded theory (Case Study: Telecom Operator) [PDF]
پژوهشهای مدیریت عمومی, 2017 Extended Abstract Changing economic and technological paradigms, causes very significant issues in different industries, especially technology-laden ones, like telecom.
Ariyan Gholipor, Nayere Eftekhar
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Implementing the Leader Development That Counts [PDF]
, 2019 Effective leader development is too often the first casualty of high demands placed on leaders, from corporate America to the U.S. military. A comparison of these entities’ common leader development programs and workforce feedback reveals insufficient ...
Orsini, Ryan J
core +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Identifying the Components of the Talent Management of faculty Members in Universities of Medical Sciences: A Meta-synthetic Study [PDF]
مجله ایرانی آموزش در علوم پزشکی, 2021 Introduction: Talent management, especially in higher education, is important due to the main role it can play in tackling the global challenges and development of different countries. This study endeavored to identify the components of talent management
ٍElham keykha, Ahmad keykha
doaj
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
The Impact of Artificial Intelligence on Sustainable Building Technologies [PDF]
E3S Web of ConferencesWith the rapid development of artificial intelligence, the demand of urban development for talents with relevant technical and theoretical knowledge is constantly increasing, which is of great significance for the promotion of scientific and ...
Lin Ji +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source