Results 161 to 170 of about 43,841 (310)

Methodological strategies for linking superordinate life goals (values) and daily activities: a cross-sectional online study of adolescents. [PDF]

Front Psychol
Scheier LM, Hansen WB, Komarc M.
europepmc   +1 more source

DTX3L Inhibits the EMT, Metastasis, and Stem‐Like Features of Gastric Cancer Through Promoting GSK‐3β Dependent SNAI1 Decay

Advanced Science, EarlyView.
This research identifies DTX3L as a critical tumor suppressor that inhibits epithelial‐mesenchymal transition (EMT), invasion and metastasis in gastric cancer. By functioning as an E3 ubiquitin ligase, DTX3L targets the master EMT regulator SNAI1 for GSK‐3β‐dependent proteasomal degradation.
Yang Chen, Zhen Li, Jiajia Shen, Jingyu Lin, Xiaoli Zhao, Rui Zhang, Ying Han, Zhen Wang   +7 more
wiley   +1 more source

tBid‐Mediated Genetic Ablation of Connective Tissue Cells Reveals Their Key Regulatory Function During Limb Regeneration in Axolotls

Advanced Science, EarlyView.
We establish a tBid‐mediated cell ablation system in axolotls, achieve rapid and efficient ablation of multiple cell types, including muscle stem cell, spinal cord cell, and connective tissue (CT) cells. We investigate the role of CT using tBid‐mediated CT ablation and identify its essential role for limb development and regeneration.
Yan Hu, Weimin Feng, Zitian He, Jiayi Zeng, Jingyi Tang, Shulin Li, Tongbo Yu, Sulei Fu, Hui Ma, Binbin Lu, Yanmei Liu, Ji‐Feng Fei   +11 more
wiley   +1 more source

Gifted but Misunderstood? An Interpretive Systematic Review of Gifted Education Policy, Practice, and Socio-Emotional Experience in England. [PDF]

J Intell
Karakaş Mısır S, Thomas M.
europepmc   +1 more source

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source

Structural and developmental characteristics of Japanese elite athletes: a longitudinal case study of a talent identification and development programme in Fukuoka prefecture. [PDF]

Front Sports Act Living
Hagiwara M, Kinugasa T, Haramura M, Nakao T, Teshima K, Yamashita S, Shirai K.   +6 more
europepmc   +1 more source

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, EarlyView.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

Factors influencing talent development: Stories of four Hong Kong elite sportspersons

, 2013
This article reports on a small-scale qualitative study that investigates how intrapersonal and environmental factors shape the beliefs and experiences of four talented Hong Kong sportsperons. Research questions focus on how their talents were identified
Yuen, MT, Chan, R
core  

Exploring "Talent" in Medical Education: A Scoping Review. [PDF]

Perspect Med Educ
Preyra R, Mishra S, Khan H, Saha S, Dhillon A, Keuhl A, Monteiro S, Wooster EM, Gottlieb M, Peever A, Chan TM.   +10 more
europepmc   +1 more source

Talent Management and the Talent of Management [PDF]

, 2011
The topic that I have chosen to talk about, managing talent, is one that is exercising\ud the minds of organizations, large and small, domestic and global, because it\ud connects very strongly to their concerns, if they are privately owned about being\ud competitive or, if they are public bodies, about providing pubic value.
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