Results 201 to 210 of about 59,815 (294)

Thinking Outside the Binding Site: A Self‐Encapsulating Kinase Inhibitor Remodels Its Pocket to Achieve Selectivity

open access: yesAngewandte Chemie International Edition, EarlyView.
To make exceptionally effective drugs, thinking “outside the binding site” is required. This work reveals that counterintuitive targeting of a kinase‐conserved region can lead to highly selective binding. Inhibitor discovery coupled to x‐ray crystallography shows that a network of noncanonical interactions and long‐range effects of distant unique amino
Nico J. Seidler   +20 more
wiley   +1 more source

Perceptions of Colombian Olympic coaches on talent identification and development in sport: a qualitative study. [PDF]

open access: yesFront Psychol
Sánchez D   +9 more
europepmc   +1 more source

Hyperostosis frontalis interna: Observed patterns, prevalence, and dementia associations in older adults

open access: yesThe Anatomical Record, EarlyView.
Abstract Hyperostosis frontalis interna (HFI) is a frequently underrecognized condition characterized by overgrowth of the frontal endocranium, most commonly observed in post‐menopausal women. Although its etiology remains unclear, hormonal influences and a possible relationship with neurocognitive changes have been proposed.
Danielle Felsberg   +5 more
wiley   +1 more source

Histological description and bone compactness analysis of fossil (Aldabrachelys sp.) and extant Aldabra giant tortoise (Aldabrachelys gigantea) shell bone fragments

open access: yesThe Anatomical Record, EarlyView.
Abstract Aldabra Atoll, north of Madagascar and part of the Seychelles Outer Islands, is home to the Aldabra giant tortoise, Aldabrachelys gigantea, the only survivor of several species of giant tortoises that were once widespread on islands across the Western Indian Ocean.
Stefanie Herter   +9 more
wiley   +1 more source

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