Results 201 to 210 of about 20,324 (263)

Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System

Annals of Neurology, EarlyView.
Objective Tau is widely studied in neurodegeneration, yet most work has focused on canonical brain tau isoforms. A longer isoform, “big tau,” produced by inclusion of exon 4a, is expressed in the peripheral nervous system (PNS) and central nervous system (CNS) regions.
Rama Krishna Koppisetti, Nicolas R. Barthélemy, Kanta Horie, Cindy V. Ly, Kaleigh F. Roberts, Srinivas Koutarapu, Richard J. Perrin, Erin E. Franklin, Chiara Pedicone, Joshua Orrick, Justin Melendez, Timothy M. Miller, Chihiro Sato, Nupur Ghoshal, Alison M. Goate, Celeste M. Karch, Randall J. Bateman, Soumya Mukherjee   +17 more
wiley   +1 more source

Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3

Annals of Neurology, EarlyView.
Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato, John M. Hayes, Jacen Emerson, Maeha Sridharan, Toluwani Adelaja, Arsal Naeem, Alexandra F. Putka, Hayley S. McLoughlin   +7 more
wiley   +1 more source

Integration of multi-omics and network toxicology reveals TLR4-mediated nephrotoxicity induced by arecoline. [PDF]

BMC Pharmacol Toxicol
Yuan J, Chen L, Wang X, Jiang Z, Jin D, Bai Y, Pan X, Li Y, Lin F, Cai Y.   +9 more
europepmc   +1 more source

Safflower Polysaccharides Alleviate TNBS-Induced Colitis by Modulating Gut Immunity. [PDF]

Foods
Jiang C, Zhu F, Aimaier S, Zhang L, Ali MH, Fan F, Lu Y, Jia M, Wu D, Yin H, Wei J, Chu S, Liu M.   +12 more
europepmc   +1 more source

Multivitamin supplements are not superior to nutrition education in improving fat-soluble vitamin levels: A double-blind randomized controlled trial. [PDF]

Asia Pac J Clin Nutr
Yusupu S, Yang Y, Geng X, Lin Z, Sun T, Wang Z, Lu H, Deng Y.   +7 more
europepmc   +1 more source

Artificial intelligence in human resource management: models for recruitment, training, performance, compensation, and retention. [PDF]

Front Artif Intell
Safshekan M, Feili A, Shojaeifard A, Sorooshian S.   +3 more
europepmc   +1 more source