Results 1 to 10 of about 90,488 (249)
Signal Transduction and Targeted Therapy, 2023 Nonalcoholic fatty liver disease (NAFLD) which is a leading cause of chronic liver diseases lacks effective treatment. Tamoxifen has been proven to be the first-line chemotherapy for several solid tumors in clinics, however, its therapeutic role in NAFLD
Lin Wang
exaly +2 more sources
Unveiling the Impact of Morphine on Tamoxifen Metabolism in Mice in vivo
Frontiers in Oncology, 2020 Background: Tamoxifen is used to treat breast cancer and cancer recurrences. After administration, tamoxifen is converted into two more potent antitumor compounds, 4OH-tamoxifen and endoxifen by the CYP3A4/5 and 2D6 enzymes in human.
Florian Gabel +9 more
doaj +1 more source
Saudi Pharmaceutical Journal, 2020 Consumption of Cytochrome P450 2D6 (CYP2D6) inhibiting drugs along with tamoxifen treatment results in decrease in plasma concentration of endoxifen, the major active tamoxifen metabolite.
Azher Arafah +5 more
doaj +1 more source
BMC Endocrine Disorders, 2021 Background Tamoxifen, which is one of the selective estrogen receptor modulators (SERMs), can bring out life-threatening complication, e.g. hypertriglyceridemia-induced acute pancreatitis, although it is rare.
Hayato Isobe +11 more
doaj +1 more source
Impact of Irradiation on the Pharmacokinetics and Biotransformation of Tamoxifen
Frontiers in Oncology, 2022 BackgroundThe optimal procedure for combining radiotherapy (RT) with tamoxifen treatment is controversial as RT may alter the pharmacokinetics and biotransformation of tamoxifen.
Yung-Yi Cheng +14 more
doaj +1 more source
Relationship between genotypes Sult1a2 and Cyp2d6 and tamoxifen metabolism in breast cancer patients. [PDF]
PLoS ONE, 2013 Tamoxifen is a pro-drug widely used in breast cancer patients to prevent tumor recurrence. Prior work has revealed a role of cytochrome and sulfotransferase enzymes in tamoxifen metabolism.
Ana Fernández-Santander +7 more
doaj +1 more source
Behavioral and transcriptomic effects of the cancer treatment tamoxifen in mice
Frontiers in Neuroscience, 2023 IntroductionTamoxifen is a common treatment for estrogen receptor-positive breast cancer. While tamoxifen treatment is generally accepted as safe, there are concerns about adverse effects on cognition.MethodsWe used a mouse model of chronic tamoxifen ...
Elena Galvano +7 more
doaj +1 more source
Tamoxifen exacerbates morbidity and mortality in male mice receiving medetomidine anaesthesia
Animal Welfare, 2023 Tamoxifen-induced CreER-LoxP recombination is often used to induce spatiotemporally controlled gene deletion in genetically modified mice. Prior work has shown that tamoxifen and tamoxifen-induced CreER activation can have off-target effects that should ...
Victoria S Rashbrook +2 more
doaj +1 more source
NR4A1 Regulates Tamoxifen Resistance by Suppressing ERK Signaling in ER-Positive Breast Cancer
Cells, 2021 Endocrine therapy is used to treat estrogen receptor (ER)-positive breast cancer. Tamoxifen is effective against this cancer subtype. Nonetheless, approximately 30% of patients treated with tamoxifen acquire resistance, resulting in therapeutic ...
Yu Cheon Kim +3 more
doaj +1 more source
Breast Cancer Research, 2019 Background High background parenchymal uptake (BPU) on molecular breast imaging (MBI) has been identified as a breast cancer risk factor. We explored the feasibility of offering a short-term intervention of low-dose oral tamoxifen to women with high BPU ...
Carrie B. Hruska +8 more
doaj +1 more source