Results 41 to 50 of about 713,789 (264)

Ion Mobility Tandem Mass Spectrometry Enhances Performance of Bottom-up Proteomics

Molecular & Cellular Proteomics, 2014
One of the limiting factors in determining the sensitivity of tandem mass spectrometry using hybrid quadrupole orthogonal acceleration time-of-flight instruments is the duty cycle of the orthogonal ion injection system.
D. Helm, J. Vissers, Chris Hughes, Hannes Hahne, Benjamin Ruprecht, Fiona Pachl, A. Grzyb, K. Richardson, J. Wildgoose, Stefan K. Maier, H. Marx, Mathias Wilhelm, Isabelle Becher, S. Lemeer, M. Bantscheff, J. Langridge, B. Kuster   +16 more
semanticscholar   +1 more source

Repeat Expansions in PLIN4 Cause Autosomal Dominant Vacuolar Myopathy With Sarcolemmal Features

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to describe and characterize two unrelated Spanish families suffering from an autosomal dominant autophagic vacuolar myopathy caused by repeat expansions in PLIN4. Methods We evaluated the clinical phenotype and muscle imaging, and performed a genetic workup that included exome sequencing, muscle RNAseq, and long‐read genome ...
Laura Llansó, Igor Stevanovski, Germán Morís, Roger Collet‐Vidiella, Alba Segarra‐Casas, Lidia González‐Quereda, Benjamín Rodríguez‐Santiago, Pia Gallano, Rodrigo Alvarez, Ana Vesperinas, Rosa Blanco, Beatriz San‐Millán, Carmen Navarro, Isabel Illa, Gianina Ravenscroft, Ira W. Deveson, Eduard Gallardo, Montse Olivé   +17 more
wiley   +1 more source

Improved isobaric tandem mass tag quantification by ion mobility mass spectrometry.

Rapid Communications in Mass Spectrometry, 2014
RATIONALE Isobaric tandem mass tags are an attractive alternative to mass difference tags and label-free approaches for quantitative proteomics due to the high degree of multiplexing that can be performed with their implementation.
R. Sturm, Christopher B. Lietz, Lingjun Li   +2 more
semanticscholar   +1 more source

Central Dysmyelination in SSADH‐Deficient Humans and Mice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer, Henry H. C. Lee, Edward Yang, Cesar Alves, Mariarita Bertoldi, Caitlyn Fung, Spencer V. Steele, Eren Kule, Zijie Jin, Alexander Rotenberg, Jean‐Baptiste Roullet, Phillip L. Pearl   +11 more
wiley   +1 more source

Colchicine Concentrations and Relationship With Colchicine Efficacy and Adverse Events: Post Hoc Analysis of a Randomized Clinical Trial of Colchicine for Gout Flare Prophylaxis

Arthritis Care &Research, EarlyView.
Objective Our objective was to examine the relationship between colchicine plasma concentrations and clinical and demographic factors and to determine the relationship between colchicine concentrations and colchicine efficacy and colchicine‐specific adverse events.
Lisa K. Stamp, Anne Horne, Borislav Mihov, Jill Drake, Janine Haslett, Peter Chapman, Daniel F. B. Wright, Christopher Frampton, Nicola Dalbeth   +8 more
wiley   +1 more source

Postanalytical tools improve performance of newborn screening by tandem mass spectrometry

Genetics in Medicine, 2014
Purpose:The purpose of this study was to compare performance metrics of postanalytical interpretive tools of the Region 4 Stork collaborative project to the actual outcome based on cutoff values for amino acids and acylcarnitines selected by the ...
P. Hall, Gregg Marquardt, D. McHugh, R. Currier, Hao Tang, Stephanie D. Stoway, P. Rinaldo   +6 more
semanticscholar   +1 more source

Efficient and Scalable Radiative Cooling for Photovoltaics Using Solution‐Processable and Solar‐Transparent Mesoporous Nanoparticles

Advanced Functional Materials, EarlyView.
Graded refractive index (GRI) structures are prepared from the layer‐by‐layer spray coating of the mesoporous SiO2 nanoparticles, showing high solar transparency and thermal emissivity. Under outdoor conditions, after 50 days, the GRI‐coated photovoltaics show on average 6.65 ± 1.48 °C lower than that of the non‐coated references, maintaining 80.9 ± 8 ...
Heesuk Jung, Sung Yoon Min, Byungsoo Kang, Yongseok Yoo, Jihun Jang, Yeoun‐Woo Jang, Hyojeong Choi, Hyeong Won Lee, Swarup Biswas, Yongju Lee, Mansoo Choi, Phillip Lee, Min Seok Jang, Hyeok Kim, Shu Yang   +14 more
wiley   +1 more source

Optimizing Angiopep‐2 Density on Polymeric Nanoparticles for Enhanced Blood–Brain Barrier Penetration and Glioblastoma Targeting: Insights From In Vitro and In Vivo Experiments

Advanced Functional Materials, EarlyView.
The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang, Ahmed Refaat, Haoqin Li, Douer Zhu, Ziqiu Tong, Joseph Anthony Nicolazzo, Bo Peng, Hua Bai, Lars Esser, Nicolas Hans Voelcker   +9 more
wiley   +1 more source

The Frontiers of Aqueous Zinc–Iodine Batteries: A Comprehensive Review on Mechanisms, Optimization, and Industrial Prospects

Advanced Functional Materials, EarlyView.
This review provides an in‐depth understanding of all theoretical reaction mechanisms to date concerning zinc–iodine batteries. It revisits the inherent issues and solutions of zinc–iodine batteries from the perspective of industrial application. By integrating existing examples of energy storage applications, it identifies the challenges faced on the ...
Haokun Wen, Hanyu Wen, Ying Sun, Jiazhuo Li, Changlei Zhuang, Minghui Liu, Hui Li, Hua Fan, Bosi Yin, Siwen Zhang, Tianyi Ma   +10 more
wiley   +1 more source

Reproducible molecular networking of untargeted mass spectrometry data using GNPS

Nature Protocols, 2019
Global Natural Product Social Molecular Networking (GNPS) is an interactive online small molecule–focused tandem mass spectrometry (MS2) data curation and analysis infrastructure.
Allegra T. Aron, Emily C. Gentry, K. McPhail, Louis-Félix Nothias, Mélissa Nothias-Esposito, Amina Bouslimani, D. Petráš, J. Gauglitz, Nicole C. Sikora, Fernando Vargas, J. V. D. van der Hooft, Madeleine Ernst, K. Kang, Christine M. Aceves, A. Caraballo-Rodríguez, I. Koester, Kelly C. Weldon, S. Bertrand, C. Roullier, Kunyang Sun, R. Tehan, C. Boya P., Martin H. Christian, Marcelino Gutiérrez, Aldo Moreno Ulloa, Javier Andres Tejeda Mora, Randy Mojica-Flores, Johant Lakey-Beitia, Víctor Vásquez-Chaves, Yilue Zhang, A. Calderón, Nicole M. Tayler, R. Keyzers, F. Tugizimana, N. Ndlovu, A. Aksenov, Alan K. Jarmusch, Robin Schmid, A. Truman, N. Bandeira, Mingxun Wang, P. Dorrestein   +41 more
semanticscholar   +1 more source