APE1 incision activity at abasic sites in tandem repeat sequences. [PDF]
J Mol Biol, 2014 Repetitive DNA sequences, such as those present in microsatellites and minisatellites, telomeres, and trinucleotide repeats (linked to fragile X syndrome, Huntington disease, etc.), account for nearly 30% of the human genome. These domains exhibit enhanced susceptibility to oxidative attack to yield base modifications, strand breaks, and abasic sites ...
Li M +3 more
europepmc +7 more sources
Accurate detection of tandem repeats from error-prone sequences with EquiRep. [PDF]
Genome ResAbstractA tandem repeat is a sequence of nucleotides that occurs as multiple contiguous and near-identical copies positioned next to each other. These repeats play critical roles in genetic diversity, gene regulation, and are strongly linked to various neurological and developmental disorders.
Song Z, Zahin T, Li X, Shao M.
europepmc +5 more sources
Statistical approaches to detecting and analyzing tandem repeats in genomic sequences [PDF]
Frontiers in Bioengineering and Biotechnology, 2015 Tandem repeats (TRs) are frequently observed in genomes across all domains of life. Evidence suggests that some TRs are crucial for proteins with fundamental biological functions, and can be associated with virulence, resistance and infectious ...
Maria eAnisimova +3 more
doaj +4 more sources
Repeat or not repeat?—Statistical validation of tandem repeat prediction in genomic sequences [PDF]
Nucleic Acids Research, 2012 Tandem repeats (TRs) represent one of the most prevalent features of genomic sequences. Due to their abundance and functional significance, a plethora of detection tools has been devised over the last two decades.
Elke Schaper +3 more
semanticscholar +7 more sources
Local Tandem Repeat Expansion in Xist RNA as a Model for the Functionalisation of ncRNA
Non-Coding RNA, 2018 Xist, the master regulator of the X chromosome inactivation in mammals, is a 17 kb lncRNA that acts in cis to silence the majority of genes along the chromosome from which it is transcribed.
Neil Brockdorff
doaj +2 more sources
TRiCoLOR: tandem repeat profiling using whole-genome long-read sequencing data [PDF]
GigaScience, 2020 Background Tandem repeat sequences are widespread in the human genome, and their expansions cause multiple repeat-mediated disorders. Genome-wide discovery approaches are needed to fully elucidate their roles in health and disease, but resolving tandem ...
Davide Bolognini +4 more
semanticscholar +3 more sources
Tandem repeat sequences evolutionarily related to SVA-type retrotransposons are expanded in the centromere region of the western hoolock gibbon, a small ape [PDF]
Journal of Human Genetics, 2012 T. Hara +4 more
openalex +2 more sources
Tandem repeats finder: a program to analyze DNA sequences. [PDF]
Nucleic Acids Research, 1999 A tandem repeat in DNA is two or more contiguous, approximate copies of a pattern of nucleotides. Tandem repeats have been shown to cause human disease, may play a variety of regulatory and evolutionary roles and are important laboratory and analytic tools. Extensive knowledge about pattern size, copy number, mutational history, etc. for tandem repeats
Gary Benson
semanticscholar +3 more sources
Human tandem repeat sequences in forensic DNA typing. [PDF]
Legal Medicine, 2005 It has been 20 years since the first development of DNA fingerprinting and the start of forensic DNA typing. Ever since, human tandem repeat DNA sequences have been the main targets for forensic DNA analysis. These repeat sequences are classified into minisatellites (or VNTRs) and microsatellites (or STRs).
Keiji Tamaki, A. Jeffreys
semanticscholar +3 more sources
TRASH: Tandem Repeat Annotation and Structural Hierarchy
Bioinform., 2023 Motivation The advent of long-read DNA sequencing is allowing complete assembly of highly repetitive genomic regions for the first time, including the megabase-scale satellite repeat arrays found in many eukaryotic centromeres.
Piotr Włodzimierz +2 more
semanticscholar +1 more source