Results 91 to 100 of about 11,335 (232)

Tanshinone IIA sodium sulfonate facilitates endocytic HMGB1 uptake [PDF]

Biochemical Pharmacology, 2012
Our seminal discovery of high mobility group box 1 (HMGB1) as a late mediator of lethal systemic inflammation has prompted a new field of investigation for the development of experimental therapeutics. We previously reported that a major Danshen ingredient, tanshinone IIA sodium sulfonate (TSN-SS), selectively inhibited endotoxin-induced HMGB1 release ...
Yusong, Zhang, Wei, Li, Shu, Zhu, Arvin, Jundoria, Jianhua, Li, Huan, Yang, Saijun, Fan, Ping, Wang, Kevin J, Tracey, Andrew E, Sama, Haichao, Wang   +10 more
openaire   +2 more sources

Danshensu Ethyl Ester Induces Ferroptosis Through Targeted Inhibition of SLC7A11 Transport Function in NSCLC

Thoracic Cancer, Volume 17, Issue 8, April 2026.
Danshensu ethyl ester (DEE) promotes ferroptosis by targeting and inhibiting the transport function of SLC7A11, independent of the p53 pathway, thereby inhibiting NSCLC. DEE reduces intracellular cysteine and glutathione (GSH) levels, while increasing reactive oxygen species (ROS) and malondialdehyde (MDA), thereby triggering ferroptosis.
Rui Yan, Sen Xu, Meng Yan, Dongyang Wu, Jingwen Zhang, Chunsheng Zhang, Jiale Liu, You‐Jie Li, Jiankai Feng, Gui‐Wu Qu, Shu‐Yang Xie   +10 more
wiley   +1 more source

Rapid Determination of Saponins in the Honey-Fried Processing of Rhizoma Cimicifugae by Near Infrared Diffuse Reflectance Spectroscopy. [PDF]

, 2018
ObjectiveA model of Near Infrared Diffuse Reflectance Spectroscopy (NIR-DRS) was established for the first time to determine the content of Shengmaxinside I in the honey-fried processing of Rhizoma Cimicifugae.MethodsShengmaxinside I content was ...
Cheng, Genhong, Kuang, Haixue, Qian, Xiuhui, Su, Yang, Wang, Qiuhong, Wu, Lun, Yu, Haoran, Zhang, Xueting   +7 more
core   +2 more sources

Tanshinone IIA pretreatment attenuates hepatic ischemia-reperfusion

Frontiers in Bioscience, 2012
Tanshinone IIA (Tan IIA), an active component derived from Salvia miltiorrhiza root, has been used to treat various ischemic cardiovascular and cerebrovascular diseases. However, its impact on hepatic ischemia/reperfusion (I/R) injury remains unclear. Here, we addressed this issue by using a 90-minute partial liver ischemia model.
Yan-yan, Qi, Liang, Xiao, Lu-ding, Zhang, Shao-hua, Song, Yi, Mei, Teng, Chen, Jian-ming, Tang, Fang, Liu, Guo-shan, Ding, Yong-zhao, Shi, Quan-xing, Wang   +10 more
openaire   +2 more sources

Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases

Cell Proliferation, Volume 59, Issue 4, April 2026.
Engineered BMSCs and vesicles enhance therapy effects for bone diseases via multi‐strategic approaches. ABSTRACT Bone‐related diseases (e.g., osteoporosis, osteoarthritis and fractures) exhibit a rising global incidence, imposing significant burdens on both quality of life and healthcare systems.
Xuemei Long, Dan Tan, Qianke Tao, Qiaonan Ye, Luwen Ye, Qing Li, Jingang Xiao   +6 more
wiley   +1 more source

Effects of the coexisting diterpenoid tanshinones on the pharmacokinetics of cryptotanshinone and tanshinone IIA in rat

European Journal of Pharmaceutical Sciences, 2007
Tanshinone II(A) and cryptotanshinone are the main pharmacologically active components in the Chinese herb drug Salvia miltiorrhiza Bge. The objective of this study was to investigate the effect of coexisting tanshinones in liposoluble ethanol extract of S. miltiorrhiza Bge.
Min, Song, Tai-Jun, Hang, Zhengxing, Zhang, Hong-Yuan, Chen   +3 more
openaire   +2 more sources

Targeting Ferroptosis With Natural Products for the Treatment of Skeletal System Disease: An Updated Review

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Skeletal system diseases, encompassing chronic disorders of the skeletal system which commonly include osteoarthritis, rheumatoid arthritis, osteoporosis and osteosarcoma. Their incidence rates have been increasing in recent years, resulting in significant social and economic burdens.
Qian Yi, Jinye Li, Guotian Luo, Jiachen Li, Dahang Yang, Wei Sun, Weichao Sun, Wei You, Lei Yang   +8 more
wiley   +1 more source

Metabolic origins and transport of vitamin e biosynthetic precursors [PDF]

, 2017
Tocochromanols are organic compounds mostly produced by photosynthetic organisms that exhibit vitamin E activity in animals. They result from the condensation of homogentisate with four different polyprenyl side chains derived all from geranylgeranyl ...
Mène-Saffrané, Laurent, Pellaud, Sébastien   +1 more
core   +2 more sources

Discovery of tanshinone derivatives with anti-MRSA activity via targeted bio-transformation

Synthetic and Systems Biotechnology, 2016
Two potent anti-MRSA tanshinone glycosides (1 and 2) were discovered by targeted microbial biotransformation, along with rapid identification via MS/MS networking.
Wenni He, Miaomiao Liu, Pei Huang, Wael M. Abdel-Mageed, Jianying Han, Jeramie D. Watrous, Don D. Nguyen, Wenzhao Wang, Fuhang Song, Huanqin Dai, Jingyu Zhang, Ronald J. Quinn, Tanja Grkovi, Houwei Luo, Lixin Zhang, Xueting Liu   +15 more
doaj   +1 more source

From Synthesis to Therapeutics: Bioactive‐Coated Zein Nanoparticles in Drug Delivery

Biopolymers, Volume 117, Issue 2, March 2026.
ABSTRACT Polymeric zein nanoparticles (ZNP), derived from corn protein, are biodegradable drug carriers with high stability and low synthesis costs. Their amphiphilic nature allows efficient encapsulation of both hydrophilic and lipophilic drugs, making them promising for drug delivery.
Milena Ferreira de Lima, Andy Joel Taipe Huisa, Azael da Silva Neto, Clarice Beatriz Gonçalves Silva, Iago Dillion Lima Cavalcanti, Karolliny Barbosa de Araújo, Mariane Cajubá de Britto Lira‐Nogueira, Nereide Stela Santos Magalhães, Priscila Gubert   +8 more
wiley   +1 more source