Tanshinone IIA inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation via Akt/Skp2/p27-associated pathway. [PDF]
We previously showed that tanshinone IIA ameliorated the hypoxia-induced pulmonary hypertension (HPH) partially by attenuating pulmonary artery remodeling.
Ying Luo +7 more
doaj +1 more source
A Friendly Relationship between Endophytic Fungi and Medicinal Plants: A Systematic Review [PDF]
Endophytic fungi or endophytes exist widely inside the healthy tissues of living plants, and are important components of plant micro-ecosystems. Over the long period of evolution, some co-existing endophytes and their host plants have established a ...
Abd_Allah +141 more
core +1 more source
Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions
Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian +8 more
wiley +1 more source
Rapid Determination of Saponins in the Honey-Fried Processing of Rhizoma Cimicifugae by Near Infrared Diffuse Reflectance Spectroscopy. [PDF]
ObjectiveA model of Near Infrared Diffuse Reflectance Spectroscopy (NIR-DRS) was established for the first time to determine the content of Shengmaxinside I in the honey-fried processing of Rhizoma Cimicifugae.MethodsShengmaxinside I content was ...
Cheng, Genhong +7 more
core +2 more sources
Traditional Chinese medicine (TCM) faces great challenges during the development of modern medicine. Utilizing novel technologies such as artificial intelligence (AI) and nanotechnology facilitates TCM with great potential in precision diagnosis and improved treatments efficacy.
Wenqi Yu +7 more
wiley +1 more source
Tanshinone IIA Protects Against Cardiac Hypertrophy via Inhibiting Calcineurin/Nfatc3 Pathway
Pathological cardiac hypertrophy induced by adrenergic overactivation can subsequently develop to heart failure which remains as a leading cause of mortality worldwide.
Xueying Tan, Jianping Li, Xinyue Wang, Nan Chen, Benzhi Cai, Gang Wang, Hongli Shan, Deli Dong, Yanju Liu, Xingda Li, Fan Yang, Xin Li, Peng Zhang, Xueqi Li, Baofeng Yang, Yanjie Lu
doaj
Solid Dispersions as a Tool for Innovation in the Food Industry: A Path From Pharma to Food
ABSTRACT Solid dispersion (SD) is a technique used to improve the solubility of poorly water‐soluble compounds by dispersing them in a solid water‐friendly carrier. Current trends indicate that natural‐based alternatives are increasingly replacing synthetic carriers, benefiting the pharmaceutical industry, where they were first adopted, and paving the ...
Stephany C. de Rezende +3 more
wiley +1 more source
Tanshinone IIA sodium sulfonate facilitates endocytic HMGB1 uptake [PDF]
Our seminal discovery of high mobility group box 1 (HMGB1) as a late mediator of lethal systemic inflammation has prompted a new field of investigation for the development of experimental therapeutics. We previously reported that a major Danshen ingredient, tanshinone IIA sodium sulfonate (TSN-SS), selectively inhibited endotoxin-induced HMGB1 release ...
Yusong, Zhang +10 more
openaire +2 more sources
An overview of the anti-cancer actions of Tanshinones, derived from Salvia miltiorrhiza (Danshen)
Tanshinone is a herbal medicinal compound described in Chinese medicine, extracted from the roots of Salvia miltiorrhiza (Danshen). This family of compounds, including Tanshinone IIA and Tanshinone I, have shown remarkable potential as anti-cancer ...
Irum Naz +7 more
doaj +1 more source
Advanced Technologies for Oral Controlled Release: Cyclodextrins for oral controlled release [PDF]
Cyclodextrins (CDs) are used in oral pharmaceutical formulations, by means of inclusion complexes formation, with the following advantages for the drugs: (1) solubility, dissolution rate, stability and bioavailability enhancement; (2) to modify the drug ...
A Al-Omar +153 more
core +1 more source

