Monoamine Oxidase Inhibition by Major Tanshinones from Salvia miltiorrhiza and Selective Muscarinic Acetylcholine M4 Receptor Antagonism by Tanshinone I [PDF]
Biomolecules, 2021 Monoamine oxidases (MAOs) and muscarinic acetylcholine receptors (mAChRs) are considered important therapeutic targets for Parkinson’s disease (PD). Lipophilic tanshinones are major phytoconstituents in the dried roots of Salvia miltiorrhiza that have ...
Ritu Prajapati +6 more
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Tanshinone I, tanshinone IIA, and cryptotanshinone: key bioactive components modulating vascular smooth muscle cell function [PDF]
Frontiers in PharmacologyCardiovascular diseases (CVDs) remain the leading cause of mortality among non-communicable diseases worldwide. Vascular smooth muscle cells (VSMCs), as the predominant cellular component of the tunica media, are essential for maintaining vascular ...
Jixin Li +8 more
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Research and Development of Natural Product Tanshinone I: Pharmacology, Total Synthesis, and Structure Modifications [PDF]
Frontiers in Pharmacology, 2022 Salvia miltiorrhiza (S. miltiorrhiza), which has been used for thousands of years to treat cardiovascular diseases, is a well-known Chinese medicinal plant. The fat-soluble tanshinones in S.
Xing Huang +7 more
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Tanshinone-I for the treatment of uterine fibroids: Molecular docking, simulation, and density functional theory investigations [PDF]
Saudi Pharmaceutical Journal, 2023 Uterine fibroids (UF), most prevalent gynecological disorder, require surgery when symptomatic. It is estimated that between 25 and 35 percent of women wait until the symptoms have worsened like extended heavy menstrual bleeding and severe pelvic pain ...
Abhishek Tiwari +12 more
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Tanshinone I suppresses hepatocellular carcinoma cells growth through targeting DNA double-strand break repair [PDF]
Cancer Biology & Therapy, 2023 Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumors with increasing incidence rates and high mortality rates. The currently available methods for treating HCC include surgery, radiotherapy or chemotherapy, but all of them ...
Zhen Qian, Nannan Feng, Anke Geng
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Tanshinone I as a novel therapeutic agent targeting von Willebrand factor-binding protein to mitigate Staphylococcus aureus pathogenicity [PDF]
VirulenceStaphylococcus aureus (S. aureus) is a prevalent pathogen responsible for a wide range of diseases in humans, contributing to both hospital-acquired and community-acquired infections.
Shiyu Zhou +9 more
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Synthesis and biological activity study of tanshinone I-pyridinium salt derivatives [PDF]
Natural Products and BioprospectingNatural product tanshinone I exhibits weak potency and poor drug-like properties, which have restricted its clinical development as an anticancer agent.
Huimin Zhao +9 more
doaj +2 more sources
Tanshinone I Inhibits Oxidative Stress-Induced Cardiomyocyte Injury by Modulating Nrf2 Signaling. [PDF]
Front Pharmacol, 2021 Cardiovascular disease, a disease caused by many pathogenic factors, is one of the most common causes of death worldwide, and oxidative stress plays a major role in its pathophysiology. Tanshinone I (Tan I), a natural compound with cardiovascular protective effects, is one of the main active compounds extracted from Salvia miltiorrhiza.
Wu YT +11 more
europepmc +5 more sources
Metabolism of Tanshinone IIA, Cryptotanshinone and Tanshinone I from Radix Salvia Miltiorrhiza in Zebrafish [PDF]
Molecules, 2012 The study aimed to investigate the potential of zebrafish in imitating mammal phase I metabolism of natural compounds. Three diterpenoid quinones from Radix Salvia miltiorrhiza, namely tanshinone IIA (TIIA), cryptotanshinone (Cry) and tanshinone I (TI ...
Bing Wang +7 more
doaj +3 more sources
Tanshinone I Ameliorates Psoriasis-Like Dermatitis by Suppressing Inflammation and Regulating Keratinocyte Differentiation [PDF]
Drug Design, Development and TherapyQiao Wang,1,* Xin Luo,1,* Yuwen Su,1 Yi Jin,1 Qiqi Kuang,1 Siying Li,1 Weiyun Shen,2 Yanshan Zhu1 1Department of Dermatology, Second Xiangya Hospital, Hunan Key Laboratory of Medical Epigenomics, Clinical Medical Research Center of Major Skin ...
Wang Q +7 more
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