Results 11 to 20 of about 5,178 (152)

Tanshinone I improves renal fibrosis by promoting gluconeogenesis through upregulation of peroxisome proliferator-activated receptor-γ coactivator 1α [PDF]

Renal Failure
Background Renal fibrosis, a hallmark of chronic kidney disease, is closely associated with dysregulated gluconeogenesis. Tanshinone I (Tan I), a bioactive compound derived from the traditional Chinese medicine Danshen, exhibits antifibrotic and anti ...
Yanfang Bai, Hui Wen, Junyan Lin, Xinying Liu, Hua Yu, Ming Wu, Ling Wang, Dongping Chen   +7 more
doaj   +2 more sources

Development of a Series of Tanshinone Derivatives Through Scaffold Hopping for Treating Non-Small-Cell Lung Cancer (NSCLC) [PDF]

Molecules
Non-small-cell lung cancer (NSCLC) is one of the most prevalent cancer types and accounts for the majority of cancer-related deaths worldwide. Tanshinone and its derivatives exhibit diverse biological activities, and their prominent antitumor potential ...
Lan-Xin Zhou, Zheng-Yu Shu, Heng Li, Hui Zhong, Dou-Nan Xu, Lei Tang, Chu-Jiao Hu, Cheng Luo, Huan Xiong   +8 more
doaj   +2 more sources

CRISPR/Cas9-mediated uORF engineering enhances tanshinone biosynthesis in <i>Salvia miltiorrhiza</i>. [PDF]

Hortic Res
Abstract Tanshinone accumulation serves as a critical determinant of medicinal value in Salvia miltiorrhiza cultivars. Precise fine-tuning of tanshinone biosynthesis while preserving elite agronomic traits remains a pivotal challenge in molecular breeding.
Shao J, Peng B, Zheng H, Li L, Li D, Hu X, Huang L, Tang K.   +7 more
europepmc   +2 more sources

Analysis of the HD-Zip I transcription factor family in Salvia miltiorrhiza and functional research of SmHD-Zip12 in tanshinone synthesis [PDF]

PeerJ, 2023
Background The homeodomain-leucine zipper I (HD-Zip I) transcription factor is a plant-specific protein that plays an essential role in the abiotic stress response of plants.
Yanhong Bai, Ying Zhou, Qiaoqi Lei, Yu Wang, Gaobin Pu, Zhenhua Liu, Xue Chen, Qian Liu   +7 more
doaj   +2 more sources

Identification of the Genome-Wide Expression Patterns of Non-Coding RNAs Associated with Tanshinones Synthesis Pathway in Salvia miltiorrhiza

Agronomy, 2023
The red root of Salvia miltiorrhiza Bunge, a famous traditional Chinese medicine (TCM), was caused by tanshinone in epidermis cells. In order to study the biological function of ncRNAs in the tanshinone synthesis, the expression patterns of mRNA and ...
Caicai Lin, Changhao Zhou, Zhongqian Liu, Xingfeng Li, Zhenqiao Song   +4 more
doaj   +1 more source

Anticancer Effect of Tanshinones on Female Breast Cancer and Gynecological Cancer

Frontiers in Pharmacology, 2022
Female breast cancer, ovarian cancer, cervical cancer, and endometrial cancer are the most common tumors and the most common causes of cancer-related mortality worldwide in women.
Zhou Jin, Zhou Jin, Yu Chenghao, Peng Cheng, Peng Cheng, Peng Cheng   +5 more
doaj   +1 more source

Salvia columbariae contains tanshinones [PDF]

Evidence-Based Complementary and Alternative Medicine, 2005
Salvia columbariae (chia) was examined and found to contain miltionone II, cryptotanshinone and tanshinone IIA. These compounds may be of interest in the treatment of stroke and heart attack.
Adams, James D., Wall, Michael, Garcia, Cecilia   +2 more
openaire   +2 more sources

Screening of Potential Thrombin and Factor Xa Inhibitors from the Danshen–Chuanxiong Herbal Pair through a Spectrum–Effect Relationship Analysis

Molecules, 2021
In this study; a spectrum–effect relationship analysis combined with a high-performance liquid chromatography–mass spectrometry (LC–MS) analysis was established to screen and identify active components that can inhibit thrombin and factor Xa (THR and FXa)
Xu Wang, Dai-Yan Zhang, Shi-Jun Yin, Hui Jiang, Min Lu, Feng-Qing Yang, Yuan-Jia Hu   +6 more
doaj   +1 more source

Tanshinone IIA Downregulates Lipogenic Gene Expression and Attenuates Lipid Accumulation through the Modulation of LXRα/SREBP1 Pathway in HepG2 Cells

Biomedicines, 2021
Abnormal and excessive accumulation of lipid droplets within hepatic cells is the main feature of steatosis and nonalcoholic fatty liver disease (NAFLD) or metabolic-associated fatty liver disease (MAFLD).
Wan-Yun Gao, Pei-Yi Chen, Hao-Jen Hsu, Ching-Yen Lin, Ming-Jiuan Wu, Jui-Hung Yen   +5 more
doaj   +1 more source

Total Syntheses of Tanshinone-I, Tanshinone-II and Cryptotanshinone [PDF]

Bulletin of the Chemical Society of Japan, 1968
Abstract Total syntheses of tanshinone-II (II) and cryptotanshinone (III) from 3-methylbenzofuran-4, 7-quinone (X) and 6,6-dimethyl-l-vinylcyclohexene (IX), and of tanshinone-I (I) from quinone X and o-methylstyrene (XVIII) are described. Preliminary accounts for the Diels-Alder reaction of methoxybenzoquinone revealed that the effect of
Hiroshi Kakisawa, Yoshinobu Inouye
openaire   +1 more source