Results 1 to 10 of about 8,021 (203)

Tanshinone IIA inactivates Akt and induces caspase-dependent death in cervical cancer cells via the mitochondrial pathway [PDF]

Bangladesh Journal of Pharmacology, 2015
In human cervical cancer cells pro-apoptotic effect of tanshinone IIA isolated from the ethanol extract of Scutellaria barbata was investigated. Tanshinone IIA treatment resulted in apoptosis and mitochondrial membrane potential loss in the cervical ...
Hu Li, Lei He, Li Yang, Yan Xu
core   +5 more sources

Tanshinone IIA attenuates hepatic stellate cell activation, oxidative stress, and liver fibrosis by inhibiting YAP signaling. [PDF]

Eur J Histochem
Tanshinone IIA is derived from Salvia miltiorrhiza and has multiple therapeutic targets and functions. The exact therapeutic effects on liver fibrosis as well as the underlying hepatoprotective mechanisms are still lacking.
Wang D, Tan Q, Zheng Q, Ma Y, Feng L.
europepmc   +2 more sources

Tanshinone IIA attenuates interleukin-17A-induced systemic sclerosis patient-derived dermal vascular smooth muscle cell activation via inhibition of the extracellular signal-regulated kinase signaling pathway [PDF]

Clinics, 2015
OBJECTIVE: Salvia miltiorrhiza has long been used to treat systemic sclerosis. Tanshinone IIA, one of the phytochemicals derived from the roots of Salvia miltiorrhiza, exhibits multiple biological activities.
Li, Ming, Liu, Mengguo, Yang, Ji
core   +6 more sources

Efficacy of tanshinone IIA in rat models with myocardial ischemia-reperfusion injury: a systematic mini-review and meta-analysis. [PDF]

PeerJ
Background Myocardial ischemia–reperfusion injury (MIRI) refers to severe damage to the ischemic myocardium following the restoration of blood flow, and it is a major complication of reperfusion therapy for myocardial infarction.
Zhang X, Jiang H, Zhang L, Chen C, Xing M, Du D, Li Y, Ma Y, Ma Y, Li C.   +9 more
europepmc   +3 more sources

Tanshinone IIA Inhibits High Glucose-Induced Collagen Synthesis via Nuclear Factor Erythroid 2-Related Factor 2 in Cardiac Fibroblasts [PDF]

Cellular Physiology and Biochemistry, 2018
Background/Aims: Diabetes is associated with increased incidence of myocardial dysfunction, which is partly characterized by interstitial and perivascular fibrosis.
Chien-Sung Tsai, Chung-Yi Lee, Shiao-Ping Lee, Shih-Hurng Loh, Tzu-Hurng Cheng, Yen-Lin Chen, Yi-Ting  Tsai   +6 more
core   +3 more sources

Tanshinone IIA alleviates tri-ortho-cresyl phosphate-induced ovarian damage through Hippo signaling pathway activation in mice. [PDF]

J Ovarian Res
Background Tri-ortho-cresyl phosphate (TOCP), a widely used plasticizer, has been shown to impair ovarian function. While tanshinone IIA exhibits ovarian protective effects in aging models, its potential to counteract TOCP-induced ovarian damage and ...
Ma Z, Hu N, Zheng L, Xue Y, Zhou C, Wang W, Cheng X, Luo T, Yu J, Hu L.   +9 more
europepmc   +2 more sources

Tanshinone IIA affects the proliferation of A549/Tax by affecting the expression of MMP7 through the PI3K-AKT-mTOR signaling pathway. [PDF]

Discov Oncol
Objective This study aims to explore whether tanshinone IIA can act on paclitaxel-resistant non-small cell lung cancer A549/Tax and analyze the possible mechanisms involved. Methods Using the Cell Counting Kit-8 (CCK-8), we preliminarily analyzed whether
Chen F, Xiang W, Qiang G.
europepmc   +2 more sources

Plant Compounds Inhibit the Growth of W12 Cervical Precancer Cells Containing Episomal or Integrant HPV DNA; Tanshinone IIA Synergizes with Curcumin in Cervical Cancer Cells. [PDF]

Viruses
This study explores the effects of plant compounds on human papillomavirus (HPV)-induced W12 cervical precancer cells and bioelectric signaling. The aim is to identify effective phytochemicals, both individually and in combination, that can prevent and ...
Einbond LS, Zhou J, Huang K, Castellanos MR, Mbazor E, Balick M, Ma H, DeVoti JA, Redenti S, Wu HA.   +9 more
europepmc   +2 more sources

Efficacy and safety of tanshinone IIA in combination with mesalazine in the treatment of ulcerative colitis: a Systematic review and meta-analysis. [PDF]

BMC Gastroenterol
Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by relapsing inflammation of the colon. Tanshinone IIA, a compound derived from traditional Chinese medicine, has demonstrated anti-inflammatory properties and may ...
Chen X, Zhou Q, Wang B, Feng D, Jiang R, Wang X.   +5 more
europepmc   +2 more sources

Tanshinone IIA attenuates AOM/DSS-induced colorectal tumorigenesis in mice via inhibition of intestinal inflammation

Pharmaceutical Biology, 2021
Context Tanshinone IIA is a natural extract derived from a Chinese medicinal herb with multiple bioactivities; however, whether and how tanshinone IIA protects against colorectal cancer (CRC) are uncertain.
Lijie Liu, Hanjing Gao, Tao Wen, Tao Gu, Shuang Zhang, Zhiyong Yuan   +5 more
doaj   +1 more source