Results 111 to 120 of about 8,021 (203)
Tanshinone IIA Protects against Dextran Sulfate Sodium- (DSS-) Induced Colitis in Mice by Modulation of Neutrophil Infiltration and Activation [PDF]
, 2016 Neutrophils play a critical role in the initiation and maintenance of intestinal inflammation. However, conventional neutrophil-targeted therapies can impair normal host defense.
Fuquan Liu +6 more
core +2 more sources
Mediators of Inflammation, Volume 2026, Issue 1, 2026.Severe acute pancreatitis (SAP) is associated with high morbidity and mortality. Microcirculatory dysfunction is a critical pathological event in this process and a primary contributor to organ failure (OF). Despite the pivotal role of P‐selectin in mediating the adhesion of activated platelets and leukocytes to the vascular endothelium, a process ...
Yali Liu +10 more
wiley +1 more source
Tanshinone IIA protects against pulmonary arterial hypertension in broilers
Poultry Science, 2017 This investigation was conducted to study the effects of tanshinone IIA (TIIA) on pulmonary arterial hypertension (PAH) in broilers. Two-hundred newly hatched Arbor Acre commercial broilers were randomly divided into 3 groups. All groups, with the exception of the control group (tap water), were given NaCl water (0.3%) starting on the d 15, and ...
Guoliang, Hu +10 more
openaire +2 more sources
Discovery of tanshinone derivatives with anti-MRSA activity via targeted bio-transformation
Synthetic and Systems Biotechnology, 2016 Two potent anti-MRSA tanshinone glycosides (1 and 2) were discovered by targeted microbial biotransformation, along with rapid identification via MS/MS networking.
Wenni He +15 more
doaj +1 more source
Pain Research and Management, Volume 2026, Issue 1, 2026.Advanced cancer continues to pose a substantial global challenge, with complex symptom burdens and limited therapeutic options. Traditional Chinese Medicine (TCM), grounded in holistic theory and the principles of syndrome differentiation, employs interventions such as herbal medicine, acupuncture, moxibustion, and acupoint‐based therapies to address ...
Chunmeng Jiao +6 more
wiley +1 more source
Sodium tanshinone IIA sulfonate stimulated Cl− secretion in mouse trachea
PLOS ONE, 2017 Sodium tanshinone IIA sulfonate (STS) is a derivate of tanshinone IIA, a lipophilic compound in Salvia miltiorrhiza. This study aimed to investigate the effect of STS on ion transport in mouse tracheal epithelium and the mechanisms underlying it. Short-circuit current (Isc) was measured to evaluate the effect of STS on transepithelial ion transport ...
Peng-Xiao Chen +6 more
openaire +4 more sources
Ferric Citrate Attenuates Cardiac Hypertrophy and Fibrosis in a Rat Model of Chronic Kidney Disease. [PDF]
, 2019 IntroductionChronic kidney disease (CKD) promotes hypertrophy and fibrosis in heart, and increases the risk of cardiovascular mortality. Ferric citrate is a dietary phosphate binder used to control hyperphosphatemia in CKD patients.
Goto, Masaki +6 more
core +1 more source
Cytochrome P450 enzyme mediated herbal drug interactions (Part 2) [PDF]
, 2014 To date, a number of significant herbal drug interactions have their origins in the alteration of cytochrome P450 (CYP) activity by various phytochemicals. Among the most noteworthy are those involving St.
Phopin, Kamonrat +2 more
core
Emerging role of nuclear factor erythroid 2-related factor 2 in the mechanism of action and resistance to anticancer therapies [PDF]
, 2019 Nuclear factor E2-related factor 2 (NRF2), a transcription factor, is a master regulator of an array of genes related to oxidative and electrophilic stress that promote and maintain redox homeostasis. NRF2 function is well studied in in vitro, animal and
Deeni, Yusuf Y. +3 more
core +3 more sources
Cellular Physiology and Biochemistry, 2015 Aims: Estrogen plays a protective role in atherosclerosis. Our preliminary work demonstrated that the active conformation of Tanshinone IIA(TanIIA) is similar to the 17ß-estradiol and it can bind to the estrogen receptor.
Xin Liu +7 more
doaj +1 more source