Results 21 to 30 of about 8,021 (203)

Tanshinone IIA sodium sulfonate facilitates endocytic HMGB1 uptake [PDF]

Biochemical Pharmacology, 2012
Our seminal discovery of high mobility group box 1 (HMGB1) as a late mediator of lethal systemic inflammation has prompted a new field of investigation for the development of experimental therapeutics. We previously reported that a major Danshen ingredient, tanshinone IIA sodium sulfonate (TSN-SS), selectively inhibited endotoxin-induced HMGB1 release ...
Yusong, Zhang, Wei, Li, Shu, Zhu, Arvin, Jundoria, Jianhua, Li, Huan, Yang, Saijun, Fan, Ping, Wang, Kevin J, Tracey, Andrew E, Sama, Haichao, Wang   +10 more
openaire   +2 more sources

Renoprotective Effects of Tanshinone IIA: A Literature Review

Molecules, 2023
The kidney is an important organ in the human body, with functions such as urine production, the excretion of metabolic waste, the regulation of water, electrolyte and acid–base balance and endocrine release. The morbidity and mortality of kidney diseases are increasing year by year worldwide, and they have become a serious public health problem.
Zhengtao Chen, Haoyue Feng, Chuan Peng, Zehua Zhang, Qianghua Yuan, Hong Gao, Shiyun Tang, Chunguang Xie   +7 more
openaire   +3 more sources

Tanshinone IIA protects against dopaminergic neuron degeneration via regulation of DJ-1 and Nrf2/HO-1 pathways in a rodent model of Parkinson’s disease [PDF]

, 2021
Purpose: To study the potential neuroprotective effects of tanshinone IIA, a diterpene quinone, in an experimental model of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced Parkinson disease (PD).
Ji, Xingwang, Shu, Zunhua, Wang, Yahong, Zhang, Jingzhou   +3 more
core   +2 more sources

Tanshinone IIA Has a Potential Therapeutic Effect on Kawasaki Disease and Suppresses Megakaryocytes in Rabbits With Immune Vasculitis

Frontiers in Cardiovascular Medicine, 2022
Background and ObjectiveIt is urgent to find out an alternative therapy for Kawasaki disease (KD) since around 20% patients are resistant to intravenous immunoglobulin (IVIG) or aspirin.
Hui Chen, Huiying Shu, Weiqing Su, Bo Li, Bo Li, Hua Zhang, Liang Li, Chao Lin, Wenfang Yi, Xiao-Yong Zhan, Chun Chen, Xiaojing Li, Yanqi Yang, Min Zhou, Mo Yang, Mo Yang   +15 more
doaj   +1 more source

Tanshinone IIA Protects Against Cerebral Ischemia Reperfusion Injury by Regulating Microglial Activation and Polarization via NF-κB Pathway

Frontiers in Pharmacology, 2021
Tanshinone IIA, a fat-soluble diterpenoid isolated from Salvia miltiorrhiza Bunge, has been shown to attenuate the cerebral ischemic injury. The aim of this study was to examine the effects on neuroprotection and microglia activation of Tanshinone IIA ...
Zhibing Song, Zhibing Song, Jingjing Feng, Qian Zhang, Shanshan Deng, Dahai Yu, Yuefan Zhang, Tiejun Li   +7 more
doaj   +1 more source

PPARG is a potential target of Tanshinone IIA in prostate cancer treatment: a combination study of molecular docking and dynamic simulation based on transcriptomic bioinformatics

European Journal of Medical Research, 2023
Tanshinone IIA is a lipophilic organic compound from the root of Danshen (Salvia miltiorrhiza) and is one of the most well-known Tanshinone molecules by pharmacologists.
Tongtong Zhang, Xinglin Chen, Xiran Ju, Jixiang Yuan, Jielong Zhou, Zhihang Zhang, Guanqun Ju, Dongliang Xu   +7 more
doaj   +1 more source

Tissue-smashing based ultra-rapid extraction of chemical constituents in herbal medicines [PDF]

, 2014
postprin
Chen, C, Fan, Y, Li, P, Qi, LW, So, KF, Yan, CP   +5 more
core   +1 more source

Counter-current chromatography for the separation of terpenoids: A comprehensive review with respect to the solvent systems employed [PDF]

, 2014
Copyright @ 2014 The Authors.This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.Natural ...
A Berthod, A Berthod, A Koch, A Li, A Marston, A Maurya, A Peng, A Sun, ALM Nasser, AM Martin, AS Engelberth, AS Graham, B Diallo, B Diallo, B Medhi, B Pinel, BCB dos Santos, BK Gosse, C Zhao, CR Cheng, D Agostinho, D Du, D Fisher, D Grancher, D Wang, D Wang, D Wu, D Zhao, E Mudge, F Chen, F Chen, F Chen, F Fullas, F Gutiérrez, F He, F Oka, F Qiu, F Xiang, F Yang, G Tian, G Tian, G Wang, G Yan, GD Brown, GG Rocha, H Knapp, H Wu, H Ye, H Ye, H Zhang, HB Li, HB Li, HB Li, HB Li, HT Lu, I Slacanin, IA Sutherland, IA Sutherland, IA Sutherland, Ian Garrard, IJ Garrard, IJ Garrard, IJ Garrard, IJ Ha, J Hu, J Huang, J Liang, J Liu, J Ma, J Peng, J Wang, J Wang, J Wang, J Xie, J Xie, J Xu, J Yan, JCT Silva, JH Lee, JP Fan, JT Fischedick, JT Fischedick, JT Fischedick, K Skalicka-Woźniak, KD Yoon, KD Yoon, Krystyna Skalicka-Woźniak, KY Yoo, M Gu, M Gu, M Hamzaoui, M Lechtenberg, M Liu, M Puertas Mejia, MP Gasper, N Acton, N Fischer, N Frighetto, O Shehzad, O Shehzad, O Shehzad, O Shirota, O Shirota, P Hewitson, PA Souza De, PK Ajikumar, Q Chen, Q Du, Q Du, Q Du, Q Du, Q Du, Q Du, Q Du, QB Han, QB Han, QB Han, R Aman, R Graziose, R Roscher, R Tsao, RTS Frighetto, S Baldermann, S Baldermann, S He, S Liu, S Shi, S Wu, S Wu, S Yao, S Yao, SM Kim, SS Cicek, SY Shi, T Abbott, VF Rodrigues, VGP Severino, VP da Silva, W He, X Cao, X Han, X Qi, X Shi, X Xiao, X Xin, XC Li, XH Xiao, XY Huang, Y Cheng, Y Cheng, Y Geng, Y Ikai, Y Ito, Y Ito, Y Ito, Y Ito, Y Jiang, Y Lu, Y Lu, Y Ma, Y Wang, Y Wei, Y Wei, Y Wei, Y Yang, Y Yang, Y Yuan, Y Zhang, Y Zhao, YW Ha, YW Ha, YY Dang, Z Jiang   +172 more
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Tanshinone Iia Inhibits Megakaryopoiesis in Immune Vasculitis

Blood, 2021
Abstract Introduction Tanshinone IIA, an active component of Danshen (Salvia miltiorrhiza), has been used for centuries to treat hypercoagulation-related diseases, which attributed to its anti-platelet and anti-inflammatory effects. However, the role of Tanshinone IIA in megakaryocytes, the precursor of platelet within the bone marrow ...
Hui Chen, Min Zhou, Huiying Shu, Weiqing Su, Liuming Yang, Liang Li, Beng H Chong, Mo Yang   +7 more
openaire   +1 more source

Combining Metabolomics and Transcriptomics to Characterize Tanshinone Biosynthesis in Salvia Miltiorrhiza [PDF]

, 2014
Plant natural products have been co-opted for millennia by humans for various uses such as flavor, fragrances, and medicines. These compounds often are only produced in relatively low amounts and are difficult to chemically synthesize, limiting access ...
Cui, Guanghong, Gao, Wei, Hillwig, Matthew L, Huang, Luqi, Jackson, Alana, Peters, Reuben J, Shen, Ye, Sun, Hai-Xi, Wang, Xiao, Wang, Xiu-Jie, Xiao, Hongbin, Zhang, Liangxiao, Zhao, Nan   +12 more
core   +3 more sources