Results 41 to 50 of about 8,021 (203)

Preclinical and clinical examinations of Salvia miltiorrhiza and its tanshinones in ischemic conditions [PDF]

, 2006
Salvia miltiorrhiza (Labiatae, Laminaceae), danshen, is an annual sage mainly found in China and neighboring countries. The crude drug (dried root) and its preparations are currently used in China to treat patients suffering from heart attack, angina ...
Lien Eric, Yang Jun, Wang Rubin, Adams James   +3 more
core   +1 more source

Tanshinone IIA improves functional recovery in spinal cord injury-induced lower urinary tract dysfunction

Neural Regeneration Research, 2017
Tanshinone IIA, extracted from Salvia miltiorrhiza Bunge, exerts neuroprotective effects through its anti-inflammatory, anti-oxidative and anti-apoptotic properties. This study intravenously injected tanshinone IIA 20 mg/kg into rat models of spinal cord
Yong-dong Yang, Xing Yu, Xiu-mei Wang, Xiao-hong Mu, Feng He   +4 more
doaj   +1 more source

Prospective therapeutic potential of Tanshinone IIA: An updated overview

Pharmacological Research, 2021
In the past decades, the branch of complementary and alternative medicine based therapeutics has gained considerable attention worldwide. Pharmacological efficacy of various traditional medicinal plants, their products and/or product derivatives have been explored on an increasing scale. Tanshinone IIA (Tan IIA) is a pharmacologically active lipophilic
Mohammad Azam, Ansari, Farheen Badrealam, Khan, Haaris Ahsan, Safdari, Ahmad, Almatroudi, Mohammad A, Alzohairy, Mohammadreza, Safdari, Mehran, Amirizadeh, Suriya, Rehman, Mohammad Javed, Equbal, Mehboob, Hoque   +9 more
openaire   +2 more sources

What Does It Take to Synergistically Combine Sub-Potent Natural Products into Drug-Level Potent Combinations? [PDF]

, 2012
10.1371/journal.pone.0049969PLoS ...
A Sivachenko, AL Harvey, B Fantin, B Papp, BA Larder, Chu Qin, Chun Yan Tan, CM Overall, Cun Long Zhang, Daniel S. Sem, DJ Newman, DM Eisenberg, DX Kong, EF Carvalho-Netto, EM Williamson, EW Sayers, F Zhu, F Zhu, FR Stermitz, GA Cordell, GG Zhang, GR Zimmermann, GT Lewith, GV Georgakis, H Quach, H Wagner, H Xiong, H Yang, HA Junio, HS Kim, J Gertsch, J Jia, J Kaiser, JE Dancey, JH MacIndoe, JI Johnson, JW Li, K Hayashi, Kai Leng Tan, KS Smalley, L Dinan, L Xie, LJ Li, LL Silver, M Shabbir, M Thanou, NV Sergina, P Csermely, PH Chiu, R Barker Bausell, R Muller, R Staud, RH Shoemaker, T Efferth, TC Chou, TF Molinski, TI Oprea, W Kassouf, X Tong, XH Ma, XM Zhou, Y Pilpel, Yu Yang Jiang, Yu Zong Chen   +63 more
core   +3 more sources

Sodium Tanshinone IIA Sulfonate Attenuates Tumor Oxidative Stress and Promotes Apoptosis in an Intermittent Hypoxia Mouse Model

Technology in Cancer Research & Treatment, 2020
Objective: Intermittent hypoxia, a significant feature of obstructive sleep apnea, has pro-tumorigenic effects. Here, we investigated the effect of sodium tanshinone IIA sulfonate on oxidative stress and apoptosis in a mouse model of Lewis lung carcinoma
Xiao-Bin Zhang PhD, Xiao-Yang Chen PhD, Peng Sun MD, Xiao-Man Su Nurse, Hui-Qing Zeng PhD, Yi-Ming Zeng PhD, Miao Wang MD, Xiongbiao Luo PhD   +7 more
doaj   +1 more source

Tanshinone IIA effects on ovarian cancer cell line

Journal of Pharmacy and Pharmacology, 2018
Abstract Objectives To explore the potential therapeutic effect of Tanshinone IIA against ovarian cancer in vitro and elucidate the underlying molecular mechanism. Methods The cell survival upon Tanshinone IIA treatment was determined
Nan Li, Liang Yang, Baolian Zhang, Suqin Chen   +3 more
openaire   +2 more sources

Tanshinone IIA delays liver aging by modulating oxidative stress. [PDF]

Front Pharmacol
Organ-specific aging is increasingly recognized for its research significance, with liver aging demonstrating particular relevance due to its central role in metabolism. We have pioneered the discovery that the expression of ESRRG in the liver positively correlates with age and have established its association with clinical characteristics, including ...
Liu Q, Li X, Luo Y.
europepmc   +4 more sources

Tanshinone IIA inhibits AGEs-induced proliferation and migration of cultured vascular smooth muscle cells by suppressing ERK1/2 MAPK signaling [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): Vascular smooth muscle cells (VSMCs) play a key role in the pathogenesis of diabetic vascular disease. Our current study sought to explore the effects of tanshinone IIA on the proliferation and migration of VSMCs induced by advanced ...
Ming Lu, Ying Luo, Pengfei Hu, Liping Dou, Shuwei Huang   +4 more
doaj   +1 more source

Endothelin-1-induced hypertrophic alterations and heme oxygenase-1 expression in cardiomyoblasts are counteracted by beta estradiol: in vitro and in vivo studies [PDF]

, 2018
L
Balla, György, Barta, Tünde, Haines, David Donald, Lekli, István, Tósaki, Ágnes, Tósaki, Árpád   +5 more
core   +1 more source

Tanshinone IIA ameliorates non-alcoholic fatty liver disease through targeting peroxisome proliferator-activated receptor gamma and toll-like receptor 4

Journal of International Medical Research, 2019
Objective To investigate the cellular mechanisms of action of tanshinone IIA on the fatty liver disease induced by a high-fat diet in an animal model of non-alcoholic fatty liver disease (NAFLD).
Lu Huang, Wei Ding, Ming-Qiang Wang, Zheng-Gen Wang, Hong-Hui Chen, Wen Chen, Qiong Yang, Ting-Na Lu, Qing Yang, Ji-Man He   +9 more
doaj   +1 more source