Results 71 to 80 of about 8,021 (203)

Viral Pathogens and Pulmonary Fibrosis: EMT‐Driven Mechanisms and Insights From Traditional Chinese Medicine

Reviews in Medical Virology, Volume 36, Issue 2, March 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a serious progressive complication of the respiratory system, which is profoundly associated with persistent extracellular matrix (ECM) deposition, fibrosis, and disrupted tissue regeneration. Emerging evidence shows that epithelial–mesenchymal transition (EMT) acts as a key factor in the pathogenesis of ...
Ningzi Zang, Yingxu Wu, Pin Li, Yongming Liu, Shiwen Wang, Jiapeng Leng, Libin Zhan, Xiaodong Lyu, Lijian Pang, Jiaran Wang   +9 more
wiley   +1 more source

Anti‐Inflammatory and Immunomodulatory Mechanism of Tanshinone IIA for Atherosclerosis [PDF]

Evidence-Based Complementary and Alternative Medicine, 2014
Tanshinone IIA (Tan II A) is widely used in the treatment of cardiovascular diseases as an active component of Salvia miltiorrhiza Bunge. It has been demonstrated to have pleiotropic effects for atherosclerosis. From the anti‐inflammatory and immunomodulatory mechanism perspective, this paper reviewed major progresses of Tan IIA in antiatherosclerosis ...
Zhuo Chen, Hao Xu
openaire   +2 more sources

Therapeutic Angiogenesis of Chinese Herbal Medicines in Ischemic Heart Disease:A Review [PDF]

, 2018
Ischemic heart disease (IHD) is one of the primary causes of death around the world. Therapeutic angiogenesis is a promising innovative approach for treating IHD, improving cardiac function by promoting blood perfusion to the ischemic myocardium.
Chen, Xing, Guo, Dongqing, Jiao, Shihong, Liu, Tianhua, Murdoch, Colin E., Qu, Jia, Wang, Wei, Wang, Yong   +7 more
core   +3 more sources

Tanshinone IIA attenuates nerve structural and functional damage induced by nerve crush injury in rats. [PDF]

PLoS ONE, 2018
After peripheral nerve crush injury, the fibers of distal nerve segments gradually disintegrate, and axons regrow from the proximal nerve segment, eventually reaching the target organ.
Zhiyong Wang, Xiaomei Yang, Weiguang Zhang, Peixun Zhang, Baoguo Jiang   +4 more
doaj   +1 more source

Tanshinone IIA inhibits cardiomyocyte pyroptosis through TLR4/NF-κB p65 pathway after acute myocardial infarction

Frontiers in Cell and Developmental Biology, 2023
Background: Tanshinone IIA, derived from Radix Salviae Miltiorrhizae (Salvia miltiorrhiza Bunge), constitutes a significant component of this traditional Chinese medicine.
Ruoning Chai, Zelin Ye, Wenjing Xue, Shuqing Shi, Yi Wei, Yuanhui Hu, Huaqin Wu   +6 more
doaj   +1 more source

Ginsenoside Rg1 as a Multifunctional Therapeutic Agent: Pharmacological Properties, Molecular Mechanisms and Clinical Perspectives in Complementary Medicine

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Ginsenoside Rg1 (Rg1) from Panax ginseng shows multifunctional health effects. Although oral bioavailability is low and blood–brain barrier (BBB) penetration is limited, delivery systems such as liposomes and nanoparticles may improve exposure. Rg1 reduces inflammation/oxidative stress by inhibiting nuclear factor‐κB (NF‐κB) signaling and reactive ...
Hernán Cortés, Enrique Lima, Lorena Duarte‐Peña, Sheila I. Peña‐Corona, Zainab M. Almarhoon, Rajesh Kaverikana, Shivaprasad Shetty Mangalpady, Vinayaka Babu Shet, Nikshitha Manjeshwar, Javad Sharifi‐Rad, Jen‐Tsung Chen, Gerardo Leyva‐Gómez, William N. Setzer, Daniela Calina   +13 more
wiley   +1 more source

Atlas‐Based Mapping of Traditional Chinese Medicine Effects on Tumor Microcirculation Regulation

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background Tumor microcirculation plays a central role in the onset and progression of hypoxia, therapeutic resistance, and immune evasion within the tumor microenvironment. Traditional Chinese Medicine (TCM), characterized by its multi‐targeted and systemic regulatory properties, has garnered increasing attention for its potential to modulate
I Ho, Yijie Xie, Zhipeng Liu, Dingjun Cai   +3 more
wiley   +1 more source

Effect of Supplementation of Tanshinone IIA and Sodium Tanshinone IIA Sulfonate on the Anticancer Effect of Epirubicin: An In Vitro Study [PDF]

Evidence-Based Complementary and Alternative Medicine, 2011
Tanshinone IIA (Tan IIA) and sodium tanshinone IIA sulfonate (STS) were found to have protective effects on cardiomyocyte against adriamycin‐induced damage and may be used clinically. It is unclear whether the supplementation of STS or Tan IIA would affect the anticancer activity of anthracycline.
Chan, Szu-Erh, Lai, Hung-Wen, Su, Chin-Cheng, Kuo, Shou-Jen, Chien, Su-Yu, Lin, Hui-Yi, Chen, Dar-Ren   +6 more
openaire   +2 more sources

Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian, Jun Ge, Ni Fan, Zheng Sun, Chengcheng Zhao, Yujiao Sun, Yingpeng Li, Yunfei Li, Hui Fu   +8 more
wiley   +1 more source

Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc [PDF]

, 2010
Background Oridonin, a tetracycline diterpenoid compound, has the potential antitumor activities. Here, we evaluate the antitumor activity and action mechanisms of oridonin in colorectal cancer.
Feng-Hou Gao, Xiao-Hui Hu, Wei Li, Hua Liu, Yan-Jie Zhang, Zhu-Ying Guo, Mang-Hua Xu, Shi-Ting Wang, Bin Jiang, Feng Liu, Ying-Zheng Zhao, Yong Fang, Fang-Yuan Chen, Ying-Li Wu   +13 more
core   +2 more sources