Results 11 to 20 of about 2,773,596 (266)
PRMT5 function and targeting in cancer [PDF]
Cell Stress, 2020 Protein methyl transferases play critical roles in numerous regulatory pathways that underlie cancer development, progression and therapy-response. Here we discuss the function of PRMT5, a member of the nine-member PRMT family, in controlling oncogenic processes including tumor intrinsic, as well as extrinsic microenvironmental signaling pathways.
Hyungsoo Kim, Ze’ev A. Ronai
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Regulation, targets and functions of CSK
Frontiers in Cell and Developmental Biology, 2023 The Src family kinases (SFK) plays an important role in multiple signal transduction pathways. Aberrant activation of SFKs leads to diseases such as cancer, blood disorders, and bone pathologies. By phosphorylating and inactivating SFKs, the C-terminal Src kinase (CSK) serves as the key negative regulator of SFKs. Similar to Src, CSK is composed of SH3,
Zhu, Shudong +3 more
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Regulation, targets and functions of CHK
Frontiers in Cell and Developmental Biology, 2022 Src family kinases (SFKs) play pivotal roles in multiple signaling pathways (Yeatman, 2004). SFK activity is inhibited by phosphorylation at its C-terminal tyrosine, by CSK (C-terminal Src kinase) and CHK (CSK-homologous kinase). CHK expression is restricted to normal hematopoietic cells, brain, and colon tissues.
Shudong Zhu +5 more
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Targeting Mitochondrial Function with Chemoptogenetics
Biomedicines, 2022 Mitochondria are ATP-generating organelles in eukaryotic cells that produce reactive oxygen species (ROS) during oxidative phosphorylation (OXPHOS). Mitochondrial DNA (mtDNA) is packaged within nucleoids and, due to its close proximity to ROS production, endures oxidative base damage. This damage can be repaired by base excision repair (BER) within the
Amy Romesberg, Bennett Van Houten
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TARGET FRAGMENTATION AND FRACTURE FUNCTIONS [PDF]
Low x Physics, 1998 We analyse recent data on the production of forward neutrons in deep inelastic scattering at HERA in the framework of a perturbative QCD description for semi-inclusive processes, which includes fracture functions.
FLORIAN, D. DE, SASSOT, R.
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Identifying miRNAs, targets and functions [PDF]
Briefings in Bioinformatics, 2012 microRNAs (miRNAs) are small endogenous non-coding RNAs that function as the universal specificity factors in post-transcriptional gene silencing. Discovering miRNAs, identifying their targets and further inferring miRNA functions have been a critical strategy for understanding normal biological processes of miRNAs and their roles in the development of
Bing Liu 0002 +2 more
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Protein acylation: mechanisms, biological functions and therapeutic targets
Signal Transduction and Targeted Therapy, 2022 Metabolic reprogramming is involved in the pathogenesis of not only cancers but also neurodegenerative diseases, cardiovascular diseases, and infectious diseases.
Shuang Shang, Jing Liu, Fang Hua
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Determinants of Functional MicroRNA Targeting
Molecules and Cells, 2023 MicroRNAs (miRNAs) play cardinal roles in regulating biological pathways and processes, resulting in significant physiological effects. To understand the complex regulatory network of miRNAs, previous studies have utilized massivescale datasets of miRNA targeting and attempted to computationally predict the functional targets of miRNAs.
Hyeonseo Hwang +2 more
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Pharmacological Research, 2022 Apolipoprotein C1 (APOC1) has been found to play an essential part in proliferation and metastasis of numerous cancers, but related mechanism has not been elucidated, especially its function and role in tumor immunity.
Liwen Ren +15 more
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Acta Pharmaceutica Sinica B, 2022 Glioblastoma (GBM) is the most challenging malignant tumor of the central nervous system because of its high morbidity, mortality, and recurrence rate.
Wan Li +11 more
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