Results 21 to 30 of about 2,773,596 (266)
Chronic Urotensin-II Administration Improves Whole-Body Glucose Tolerance in High-Fat Diet-Fed Mice
Frontiers in Endocrinology, 2019 Urotensin-II (U-II) is an endogenous peptide agonist of a G protein-coupled receptor—urotensin receptor. There are many conflicting findings about the effects of U-II on blood glucose.
Xi Chen +10 more
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Hox Targets and Cellular Functions [PDF]
Scientifica, 2013 Hox genes are a group of genes that specify structures along the anteroposterior axis in bilaterians. Although in many cases they do so by modifying a homologous structure with a different (or no) Hox input, there are also examples of Hox genes constructing new organs with no homology in other regions of the body.
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TRIB3‒GSK-3β interaction promotes lung fibrosis and serves as a potential therapeutic target
Acta Pharmaceutica Sinica B, 2021 Pulmonary fibrosis (PF) is a chronic, progressive, fatal interstitial lung disease with limited available therapeutic strategies. We recently reported that the protein kinase glycogen synthase kinase-3β (GSK-3β) interacts with and inactivates the ...
Shanshan Liu +12 more
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Consideration of limitations in the form of inequalities in optimal planning of power systems regimes under uncertainty initial information [PDF]
E3S Web of Conferences, 2021 In the article the issues of taking into account of constraints in the form of inequality in optimal planning of short-term modes of power systems are considered. An efficient algorithm for solving of the problem is offered. On the basis of computational
Latipov Sh.Sh. +2 more
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Analytical solutions for some problems of optimum with applications in air traffic and economics [PDF]
INCAS Bulletin, 2014 Analytical solutions for some problems of optimum with applications in air traffic and economics are given. For air traffic minimal distances between commercial airplanes (flight corridors) are imposed considering various trajectories: straightlines ...
Corneliu BERBENTE, Sorin BERBENTE
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Vehicle power supply management strategies
Вестник СибАДИ, 2023 Introduction. To optimize the performance of the vehicle electrical system, it is necessary to improve the control principles and strategies. The control principles may be based on voltage constancy, ensuring battery charge, reducing fuel consumption ...
A. V. Puzakov
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Rules for functional microRNA targeting
BMB Reports, 2017 MicroRNAs (miRNAs) are ∼22nt-long single-stranded RNA molecules that form a RNA-induced silencing complex with Argonaute (AGO) protein to post-transcriptionally downregulate their target messenger RNAs (mRNAs). To understand the regulatory mechanisms of miRNA, discovering the underlying functional rules for how miRNAs recognize and repress their target
Kim, Doyeon +2 more
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USP13: Multiple Functions and Target Inhibition
Frontiers in Cell and Developmental Biology, 2022 As a deubiquitination (DUB) enzyme, ubiquitin-specific protease 13 (USP13) is involved in a myriad of cellular processes, such as mitochondrial energy metabolism, autophagy, DNA damage response, and endoplasmic reticulum-associated degradation (ERAD), by regulating the deubiquitination of diverse key substrate proteins. Thus, dysregulation of USP13 can
Xiaolong Li +11 more
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Link Prediction on Directed Networks Based on AUC Optimization
IEEE Access, 2018 Complex networks have become high-dimensional, sparse, and redundant due to the rapid expansion of the Internet. Effective link prediction techniques are needed to obtain the most relevant and important information for Internet users.
Bolun Chen, Yong Hua, Yan Yuan, Ying Jin
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Functions of Astrocytes and their Potential As Therapeutic Targets [PDF]
Neurotherapeutics, 2010 Astrocytes are often referred to, and historically have been regarded as, support cells of the mammalian CNS. Work over the last decade suggests otherwise-that astrocytes may in fact play a more active role in higher neural processing than previously recognized.
Harold K, Kimelberg, Maiken, Nedergaard
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