Results 51 to 60 of about 43,685,384 (257)
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Text+ auf der OPERAS-Konferenz 2024
Autor:innen: Nanette Rißler-Pipka, Angela Vorndran, Philippe Genêt, Eva-Maria Gerstner Bei der kommenden OPERAS conference 2024, die vom 24. bis zum 26.
Text+ Mitglied
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Literature evidence in open targets - a target validation platform
Journal of Biomedical Semantics, 2017 Background We present the Europe PMC literature component of Open Targets - a target validation platform that integrates various evidence to aid drug target identification and validation.
Şenay Kafkas +2 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Bei der BiblioCon 2024, die unter dem Thema "offen.lokal.global." Anfang Juni in Hamburg veranstaltet wird, ist Text+ mit mehreren Beiträgen vertreten. Die BiblioCon (ehemals "Bibliothekartag") ist die zentrale Tagung des deutschen Bibliothekswesens, die
Text+ Blog-Redaktion
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Den Blick für die jeweilige Gelegenheit öffnen
, 2023 Autor:innen: Barbara K. Fischer und Stefan Buddenbohm Ende November kamen gut 20 Mitarbeiter:innen aus unterschiedlichen Projekten mit GND-Bezug, wie NFDI-Konsortien, GND4C und GND-Redaktionen, im Arbeitskreis GND Community Empowerment zu ihrem dritten
Text+ Mitglied
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
2. Text+/RIDE-Band zu FAIRen Editionen veröffentlicht
Autor: Text+ Redaktion Wir freuen uns, ankündigen zu können, dass der zweite Teil des zweiten gemeinsamen RIDE Bandes von Text+ und dem Institut für Dokumentologie und Editorik e.V. (IDE) veröffentlicht wurde.
Text+ Blog-Redaktion
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source