Results 61 to 70 of about 653,941 (306)

Progressive cancer targeting by programmable aptamer‐tethered nanostructures

MedComm
Scientific research in recent decades has affirmed an increase in cancer incidence as a cause of death globally. Cancer can be considered a plurality of various diseases rather than a single disease, which can be a multifaceted problem.
Fatemeh Mohammadi, Hamed Zahraee, Farkhonde Zibadi, Zahra Khoshbin, Mohammad Ramezani, Mona Alibolandi, Khalil Abnous, Seyed Mohammad Taghdisi   +7 more
doaj   +1 more source

Design, Synthesis, and Evaluation of Amphiphilic Cyclic and Linear Peptides Composed of Hydrophobic and Positively-Charged Amino Acids as Antibacterial Agents

Molecules, 2018
Antimicrobial peptides (AMPs) contain amphipathic structures and are derived from natural resources. AMPs have been found to be effective in treating the infections caused by antibiotic-resistant bacteria (ARB), and thus, are potential lead compounds ...
Neda Riahifard, Saghar Mozaffari, Taibah Aldakhil, Francisco Nunez, Qamar Alshammari, Saud Alshammari, Jason Yamaki, Keykavous Parang, Rakesh Kumar Tiwari   +8 more
doaj   +1 more source

Future of 5-fluorouracil in cancer therapeutics, current pharmacokinetics issues and a way forward [PDF]

, 2019
Background: In addition to exhibiting antitumor potential, antitumor drugs exhibit toxicity due to a poor pharmacokinetic profile. An enormous amount of research has been carried out and is still ongoing to obtain more targeted, potent, and safe drugs to
Abd-Rabou, Anitha, Arias, Atrián-Blasco, Berners-Price, Bertrand, Carrillo, Chandran, Chibaudel, Clingan, DiGiulio, Esin, Gao, Gasser, Hoste, Li, Liu, Liu, Luo, Miura, Mohana, Moloney, Nadzri, Nisa, Nivethaa, Nunes, Rambabu, Rengaraj, Saǧir, Shaima, Shen, Subudhi, Sun, Tummala, Wang, Yu, Zhang, Zhang, Zhu, Álvarez   +39 more
core   +1 more source

Modelling drug coatings: A parallel cellular automata model of ethylcellulose-coated microspheres [PDF]

, 2011
Pharmaceutical companies today face a growing demand for more complex drug designs. In the past few decades, a number of probabilistic models have been developed, with the aim of improving insight on microscopic features of these complex designs.
Bezbradica, Marija, Crane, Martin, Ruskin, Heather J.   +2 more
core   +2 more sources

Nanoparticles in the treatment of chronic lung diseases [PDF]

, 2019
Nanoparticles, although considered a topic of modern medicine, actually have an interesting history. Currently, advances in nanomedicine hold great promise as drug carrier systems for sustained release and targeted delivery of diverse therapeutic agents.
Alexescu, Teodora G, Cosnarovici, Maria, Negrean, Vasile, Orasan, Olga H, Para, Ioana, Perne, Mirela G, Popovici, Ionela, Ruta, Victoria M, Tarmure, Simina, Todea, Doina A   +9 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Evaluation of ethylcellulose and its pseudolatex (Surelease) in preparation of matrix pellets of theophylline using extrusion-spheronization [PDF]

Iranian Journal of Basic Medical Sciences, 2017
Objective(s): This study evaluates the effect of substitution of microcrystalline cellulose (MCC) with ethylcellulose (EC) on mechanical and release characteristics of theophylline pellets.
Hadi Afrasiabi Garekani, Roshanak Dolatabadi, Abbas Akhgari, Mohammad Reza Abbaspour, Fatemeh Sadeghi   +4 more
doaj   +1 more source

Contact-facilitated drug delivery with Sn2 lipase labile prodrugs optimize targeted lipid nanoparticle drug delivery [PDF]

, 2015
Sn2 lipase labile phospholipid prodrugs in conjunction with contact-facilitated drug delivery offer an important advancement in Nanomedicine. Many drugs incorporated into nanosystems, targeted or not, are substantially lost during circulation to the ...
Abes, Adler, Ahmad, Amati, Andresen, Andresen, Andresen, Anguiano, Arik, Avet-Loiseau, Bagnasco, Bainbridge, Bakhru, Berg, Bernier, Bhargava, Burke, Chen, Chng, Clausen, Cresteil, Curcio, Dahan, Darnell, Davidsen, Dehousse, Dib, Edwards, El-Sayed, Eskens, Fowler, Freytag, Gabizon, Gabizon, Gabizon, Gibbs, Gilleron, Hatakeyama, Hendrikx, Herbst, Hermeking, Ibrahim, Jain, Jain, Jain, Jensen, Jones, Kaasgaard, Kiessling, Kobayashi, Krpetić, Kudelka, Kuehl, Lanza, Lanza, Lanza, Lee, Lehto, Lewis, Li, Linderoth, Liu, Logothetis, Luo, Madsen, Monach, Murre, Offodile, Ortega, Pan, Pan, Pan, Pan, Partlow, Pedersen, Pedersen, Peetla, Peters, Prochownik, Radl, Radl, Rosenholm, Schmieder, Schmieder, Shim, Shrestha, Smith, Soman, Soodgupta, Stone, Suzuki, Wang, Wiethoff, Winter, Winter, Winter, Wymer, Yin, Zalipsky, Zhang, Zhou, Zhou, Zhou, Zhou   +103 more
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source