Results 101 to 110 of about 90,676 (185)

A Quantitative HILIC–MS/MS Assay of the Metabolic Response of Huh-7 Cells Exposed to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

Metabolites, 2019
A hydrophilic interaction liquid chromatography (HILIC)−ultra high-pressure liquid chromatography (UHPLC) coupled with tandem mass spectrometry (MS/MS) method was developed and applied to profile metabolite changes in human Huh-7 cells exposed to ...
Qing Liu, Jingwei Cai, Robert G. Nichols, Yuan Tian, Jintao Zhang, Philip B. Smith, Yan Wang, Chao Yan, Andrew D. Patterson   +8 more
doaj   +1 more source

Integrative Lipid Pseudotargeted Metabolomics and Amino Acids Targeted Metabolomics Unravel the Therapeutic Mechanism of Rhizoma Paridis Saponins on Experimental Colitis of Damp-Heat Type [PDF]

Qi Wu,1,* Kexin Liu,2,* Ruijuan Hou,1 Xingxing Wu,3 Xiaoyu Ruan,4 Mao Wang,5 Zhiting Sun,6 Lingchang Meng,6 Guoliang Dai,7 Changyin Li,7 Jing Wu,1,6 Genglin Mu6 1Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, Nanjing ...
Wang M, Wu J, Liu K, Ruan X, Li C, Wu Q, Dai G, Hou R, Meng L, Mu G, Sun Z, Wu X   +11 more
core   +1 more source

Sample Preparation Strategies for the Effective Quantitation of Hydrophilic Metabolites in Serum by Multi-Targeted HILIC-MS/MS

Metabolites, 2017
The effect of endogenous interferences of serum in multi-targeted metabolite profiling HILIC-MS/MS analysis was investigated by studying different sample preparation procedures.
Elisavet Tsakelidou, Christina Virgiliou, Lemonia Valianou, Helen G. Gika, Nikolaos Raikos, Georgios Theodoridis   +5 more
doaj   +1 more source

Basal omega-3 fatty acid status affects fatty acid and oxylipin responses to high-dose n3-HUFA in healthy volunteers[S]

Journal of Lipid Research, 2012
A subject's baseline FA composition may influence the ability of dietary highly unsaturated omega-3 FAs (n3-HUFA) to change circulating profiles of esterified FAs and their oxygenated metabolites.
Alison H. Keenan, Theresa L. Pedersen, Kristi Fillaus, Mark K. Larson, Gregory C. Shearer, John W. Newman   +5 more
doaj   +1 more source

The targeted metabolomic profile of laticifers in rubber tree

Journal of Integrative Plant Biology
Targeted metabolomic profiling of rubber tree (Hevea brasiliensis) laticifers identified metabolites that were reprogramming by domestication, revealed active isoprenoid metabolism in the laticifers, and discovered loci with potential biosynthetic applications, supporting the potential of developing laticifers as bioreactors for production of valuable ...
Xiaomin Deng, Shuguang Yang, Qiang Gao, Yanling Chen, Xia Zeng, Minjing Shi, Shaohua Wu, Weimin Tian, Xuchu Wang, Jinquan Chao   +9 more
openaire   +2 more sources

Changes in L‐phenylalanine concentration reflect and predict response to anti‐PD‐1 treatment combined with chemotherapy in patients with non‐small cell lung cancer

MedComm
Chemotherapy combined with checkpoint blockade antibodies targeting programmed cell death protein (PD‐1) has achieved remarkable success in non‐small cell lung cancer. However, few patients benefit from long‐term treatment.
Yaqing Liu, Yu Ping, Liubo Zhang, Qitai Zhao, Yachang Huo, Congcong Li, Jiqi Shan, Yanwen Qi, Liping Wang, Yi Zhang   +9 more
doaj   +1 more source

Metabolomics‐driven approaches for identifying therapeutic targets in drug discovery

MedComm
Identification of therapeutic targets can directly elucidate the mechanism and effect of drug therapy, which is a central step in drug development. The disconnect between protein targets and phenotypes under complex mechanisms hampers comprehensive ...
Shanshan Pan, Luan Yin, Jie Liu, Jie Tong, Zichuan Wang, Jiahui Zhao, Xuesong Liu, Yong Chen, Jing Miao, Yuan Zhou, Su Zeng, Tengfei Xu   +11 more
doaj   +1 more source

New prognostic and diagnostic biomarkers in diabetic nephropathy using comprehensive targeted and non-targeted metabolomics. [PDF]

, 2015
Metabolomics relates to the research of metabolites, their pathways and interactions. The potential of metabolomics is shown in two studies aiming for identification of prognostic and diagnostic biomarkers for diabetic nephropathy.
Wörmann, K.
core  

Metabolomic analysis for diagnosis of oral squamous cell carcinoma using machine learning

Discover Oncology
Oral squamous cell carcinoma (OSCC) undergoes significant metabolic reprogramming. Adopting metabolomics to identify altered metabolic enzymes and metabolites holds promise for the early and precise diagnosis of OSCC. However, most current workflows rely
Wei Yuan, Jiayi Rao, Shang Han, Sen Li, Xiangjie Meng, Lizheng Qin, Xin Huang   +6 more
doaj   +1 more source

Metabolomics in Practice Successful Strategies to Generate and Analyze Metabolic Data [PDF]

, 2012
Unlike other handbooks in this emerging field, this guide focuses on the challenges and critical parameters in running a metabolomics study, including such often-neglected issues as sample preparation, choice of separation and detection method, recording
Weckwerth, Wolfram, L?mmerhofer, Michael
core