Results 201 to 210 of about 419,478 (257)

Harnessing the FBXW7 Somatic Mutant R465C for Targeted Protein Degradation. [PDF]

J Am Chem Soc
Basu AA, Zhang C, Rouhimoghadam M, Vasudevan A, Reitsma JM, Zhang X.   +5 more
europepmc   +1 more source

Toward Anti-Herpesviral PROTACs: Assessing the Challenges for Targeted Protein Degradation on the Example of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen. [PDF]

ChemMedChem
Berwanger A, Stein SC, Brandner S, Kany AM, Heinz S, Loretz B, Lehr CM, Hirsch AKH, Lermyte F, Schulz TF, Empting M.   +10 more
europepmc   +1 more source

Exploration of degrons and their ability to mediate targeted protein degradation. [PDF]

RSC Med Chem
Harris TJ, Trader DJ.
europepmc   +1 more source

Data-independent acquisition (DIA) approach for comprehensive ubiquitinome profiling in targeted protein degradation

Sathe G, Röth S, Gelders G, Brewer A, Macartney TJ, Wood NT, De Muynck L, Nakasone MA, Phung TK, Buist A, Moechars D, Sapkota GP.   +11 more
europepmc   +1 more source

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Aptamer-Based Targeted Protein Degradation

ACS Nano, 2023
The selective removal of misfolded, aggregated, or aberrantly overexpressed protein plays an essential role in maintaining protein-dominated biological processes. In parallel, the precise knockout of abnormal proteins is inseparable from the accurate identification of proteins within complex environments.
Yuan Liu, Xu Qian, Chunyan Ran, Longjie Li, Ting Fu, Dan Su, Sitao Xie, Weihong Tan   +7 more
openaire   +2 more sources

Targeted Protein Degradation via Lysosomes

Biochemistry, 2022
In the scope of targeted protein degradation (TPD), proteolysis-targeting chimeras (PROTACs), leveraging the ubiquitin-proteasome system, have been extensively studied. However, they are limited to the degradation of soluble and membrane proteins, excluding the aggregated and extracellular proteins and dysfunctional organelles.
Rishi R. Paudel, Dong Lu, Sandipan Roy Chowdhury, Erika Y. Monroy, Jin Wang   +4 more
openaire   +3 more sources

Monomeric Targeted Protein Degraders

Journal of Medicinal Chemistry, 2020
The discovery and development of targeted protein degraders have become important areas of research in the field of medicinal chemistry. Inducing degradation of a target protein presents several advantages relative to simple inhibition including a potential for extended duration of action and more profound pharmacology.
Emily J. Hanan, Jun Liang, Xiaojing Wang, Robert A. Blake, Nicole Blaquiere, Steven T. Staben   +5 more
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Targeted protein degradation mechanisms

Drug Discovery Today: Technologies, 2019
Targeted protein degradation mediated by small molecule degraders represents an exciting new therapeutic opportunity to eliminate disease-causing proteins. These molecules recruit E3 ubiquitin ligases to the protein of interest and mediate its ubiquitination and subsequent proteolysis by the proteasome.
Yi, Zhang, Christine, Loh, Jesse, Chen, Nello, Mainolfi   +3 more
openaire   +2 more sources

Clinical Translation of Targeted Protein Degraders

Clinical Pharmacology & Therapeutics, 2023
Targeted protein degradation (TPD) has emerged as a potentially transformational therapeutic modality with considerable promise. Molecular glue degraders remodel the surface of E3 ligases inducing interactions with neosubstrates resulting in their polyubiquitination and proteasomal degradation.
Nikki R. Kong, Lyn H. Jones
openaire   +2 more sources