Results 51 to 60 of about 4,214,171 (152)

Introduction to radionuclide therapy

, 2008
This introductory chapter is written for those who are new to the field and desire a short overview of the present status of clinical and preclinical radionuclide therapy. In particular, this chapter provides an overview of the radiophysical concepts and
Carlsson, Jörgen,
core   +6 more sources

Synthesis, Characterisation and Structural Analysis of Rhenium and Technetium Nitride Complexes With Tridentate Thiosemicarbazone‐Phenols and Phosphine Ligands: Potential Applications in Technetium‐99m Radiotracer Development

Bioinorganic Chemistry and Applications, Volume 2026, Issue 1, 2026.
The reactivity of two tridentate salicylthiosemicarbazones (H2L1 = 3‐methoxysalicylaldehyde thiosemicarbazone; H2L2 = 3‐methoxysalicylaldehyde N,N‐dimethyl‐thiosemicarbazone), with the [MV ≡ N]2+ core (M = Re, 99mTc), is here described, leading to the formation of heteroleptic complexes of the general composition [MN(L)P] (P = triphenylphosphine, PPh3;
Nicola Salvarese, Davide Lucchini, Carolina Gobbi, Marco Baron, Dominga Rogolino, Mauro Carcelli, Alessandro Dolmella, Cristina Bolzati, Arnab Biswas   +8 more
wiley   +1 more source

In silico assessment of cellular damage from Lu‐177, Ac‐225, and Pb‐212 therapeutic radionuclides

Medical Physics, Volume 52, Issue 11, November 2025.
Abstract Background Targeted radionuclide therapy (TRT) has emerged as a unique and effective treatment modality for cancer. Monte Carlo simulations have greatly advanced investigations into radiation‐caused DNA damage, including the complexity of this damage.
Konstantinos P. Chatzipapas, Konstantinos Papachristou, Dimitris Visvikis, Sebastien Incerti, John D. Hazle, George C. Kagadis   +5 more
wiley   +1 more source

Impact of the Monte-Carlo code GATE for targeted radionuclide therapy (TRT): imaging and dosimetric calculations

, 2015
En Radiothérapie Interne Vectorisée (RIV), l'estimation de la dose absorbée aux tumeurs et tissus sains est un outil d'évaluation. et d'optimisation du traitement. Ce travail de thèse a pour objet de déterminer l'apport du code Monte-Carlo GATE dans un contexte d'amélioration des pratiques dosimétriques en RIV.
openaire   +2 more sources

Targeting Melanin Heterogeneity in Metastatic Melanoma: A Dual‐Tumour Mouse Melanoma Model

Experimental Dermatology, Volume 34, Issue 9, September 2025.
The abscopal effect is known in external beam radiotherapy but unresolved in targeted radionuclide therapy (TRT) due to a lack of in vivo models. This study develops a B16‐OVA non‐pigmented melanoma cell line and a dual‐tumour model with pigmented and non‐pigmented melanoma to investigate the abscopal effect in melanin‐TRT.
Marine Delmas, Benjamin Chaussin, Nathan Harismendy, Aurore Dougé, Paul‐Olivier Rouzaire, Christopher Montemagno, Jérôme Durivault, Emmanuel Moreau, Elisabeth Miot‐Noirault, Mercedes Quintana, Sophie Besse, Michel D'Incan, Emmanuel Chautard, Elodie Jouberton, Jacques Rouanet   +14 more
wiley   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.
Cancer Science, Volume 117, Issue S1, Page 1-2148, January 2026.
wiley   +2 more sources

Designing combination therapies for cancer treatment: application of a mathematical framework combining CAR T-cell immunotherapy and targeted radionuclide therapy

Frontiers in Immunology
IntroductionCancer combination treatments involving immunotherapies with targeted radiation therapy are at the forefront of treating cancers. However, dosing and scheduling of these therapies pose a challenge.
Vikram Adhikarla, Dennis Awuah, Enrico Caserta, Megan Minnix, Maxim Kuznetsov, Amrita Krishnan, Jefferey Y. C. Wong, John E. Shively, Xiuli Wang, Flavia Pichiorri, Russell C. Rockne   +10 more
doaj   +1 more source

Combination of Proton Therapy and Radionuclide Therapy in Mice: Preclinical Pilot Study at the Paul Scherrer Institute

Pharmaceutics, 2019
Proton therapy (PT) is a treatment with high dose conformality that delivers a highly-focused radiation dose to solid tumors. Targeted radionuclide therapy (TRT), on the other hand, is a systemic radiation therapy, which makes use of intravenously ...
Cristina Müller, Maria De Prado Leal, Marco D. Dominietto, Christoph A. Umbricht, Sairos Safai, Rosalind L. Perrin, Martina Egloff, Peter Bernhardt, Nicholas P. van der Meulen, Damien C. Weber, Roger Schibli, Antony J. Lomax   +11 more
doaj   +1 more source

Framework to calculate 225Ac, 177Lu, and 161Tb radiation dose and biological effect in metastatic castration‐resistant prostate cancer treatment

Medical Physics, Volume 52, Issue 8, August 2025.
Abstract Background In the treatment of metastatic castration‐resistant prostate cancer (mCRPC), the standard radionuclide 177Lu (β⁻ emitter) is being challenged by alternatives, particularly the α‐emitter 225Ac and Auger electron emitter 161Tb, due to their superior radiobiological properties.
Shahin Ghaseminejad, Danny De Sarno, Glenn Bauman, Ting‐Yim Lee   +3 more
wiley   +1 more source

Cancer‐Associated Fibroblasts: Heterogeneity, Cancer Pathogenesis, and Therapeutic Targets

MedComm, Volume 6, Issue 7, July 2025.
Cancer‐associated fibroblasts (CAFs) arise from normal fibroblasts in response to various tumor microenvironmental signals, including cytokines such as TGF‐β and IL‐6, paracrine factors like PDGFs, Notch signaling, extracellular vesicles, as well as aging, inflammation, hypoxia, oxidative stress, and increased extracellular matrix (ECM) stiffness. Upon
Yutao Li, Qingyun Liu, Xilin Jing, Yuqi Wang, Xiaohua Jia, Xing Yang, Kezhong Chen   +6 more
wiley   +1 more source