Results 61 to 70 of about 4,214,171 (152)

In vitro and in vivo analyses of eFAP: a novel FAP-targeting small molecule for radionuclide theranostics and other oncological interventions

EJNMMI Radiopharmacy and Chemistry
Background Fibroblast activation protein (FAP), a transmembrane serine protease overexpressed by cancer-associated fibroblasts in the tumor stroma, is an interesting biomarker for targeted radionuclide theranostics.
Circe D. van der Heide, Hanyue Ma, Mark W.H. Hoorens, Joana D. Campeiro, Debra C. Stuurman, Corrina M.A. de Ridder, Yann Seimbille, Simone U. Dalm   +7 more
doaj   +1 more source

The current status and prospects of theranostic in targeted radionuclide therapy

肿瘤影像学
Targeted radionuclide therapy (TRT) leveraging the unique properties of radioactive pharmaceuticals to concentrate therapeutic effects within tumor tissues.
DING Ying, YANG Hui
doaj  

Prospects of covalent radionuclide drug conjugates: Research and development progress

Journal of Radiation Research and Applied Sciences
Targeted radionuclide therapy (TRT) is a key modality for the precision diagnosis and treatment of advanced malignancies. Radionuclide drug conjugates (RDCs), the main delivery vehicles of TRT, have achieved important clinical successes, but insufficient
Yu Fang, Kun Luo, Yibo Wang, Suyang Shen, Jiawei Zhou   +4 more
doaj   +1 more source

The Power of Precision:Unravelling the radiobiology of targeted radionuclide therapy [PDF]

Targeted radionuclide therapy (TRT) involves systemic administration of a radionuclide attached to a cancer-targeting moiety. It is proving to be a promising approach for primary cancer and metastasis treatment with minimal damage to surrounding tissues.
Grayson, Kelly, Terry, Samantha; id_orcid, Khanna, Ruhani, Gape, Paul, Patel, Margi   +4 more
core   +6 more sources

Myeloid-derived suppressor cells attenuate the antitumor efficacy of radiopharmaceutical therapy using 90Y-NM600 in combination with androgen deprivation therapy in murine prostate tumors

Journal for ImmunoTherapy of Cancer
Rationale Androgen deprivation therapy (ADT) is pivotal in treating recurrent prostate cancer and is often combined with external beam radiation therapy (EBRT) for localized disease.
Douglas G McNeel, Zachary S Morris, Reinier Hernandez, Jamey P Weichert, Anusha Muralidhar, Hansel Comas Rojas, Malick Bio Idrissou   +6 more
doaj   +1 more source

Recommendations for reporting preclinical radiobiological studies in targeted radionuclide therapy

The growing interest and investments in targeted radionuclide therapy (TRT) have expanded research efforts across preclinical and clinical domains. Researchers from diverse fields, including nuclear medicine, radiochemistry, radiopharmacy, radiotherapy ...
Mendes, Filipa, Terry, Samantha Y. A., Therapy, European Working Grp Radiobiology Mol Radionuclide, Cornelissen, Bart, Spiegelberg, Diana, Nonnekens, Julie, Bolcaen, Julie   +6 more
core   +1 more source

Targeted radionuclide therapy against GARP expressing T regulatory cells after tumour priming with external beam radiotherapy in a murine syngeneic model

Heliyon
Purpose: Radiation therapy (RT) exerts its anti-tumour efficacy by inducing direct damage to cancer cells but also through modification of the tumour microenvironment (TME) by inducing immunogenic antitumor response.
Pierre-Simon Bellaye, Alexandre MM. Dias, Jean-Marc Vrigneaud, Alexanne Bouchard, Mathieu Moreau, Camille Petitot, Claire Bernhard, Michael Claron, Lisa Froidurot, Véronique Morgand, Mélanie Guillemin, Marie Monterrat, Céline Mirjolet, Carmen Garrido, Evelyne Kohli, Bertrand Collin   +15 more
doaj   +1 more source

Theranostic Approach for Metastatic Pigmented Melanoma Using ICF15002, a Multimodal Radiotracer for Both PET Imaging and Targeted Radionuclide Therapy

Neoplasia: An International Journal for Oncology Research, 2017
PURPOSE: This work reports, in melanoma models, the theranostic potential of ICF15002 as a single fluorinated and iodinated melanin-targeting compound.
Latifa Rbah-Vidal, Aurélien Vidal, Emilie M.F. Billaud, Sophie Besse, Isabelle Ranchon-Cole, Florence Mishellany, Yann Perrot, Lydia Maigne, Nicole Moins, Jean-Luc Guerquin-Kern, Françoise Degoul, Jean-Michel Chezal, Philippe Auzeloux, Elisabeth Miot-Noirault   +13 more
doaj   +1 more source

Towards the Magic Radioactive Bullet: Improving Targeted Radionuclide Therapy by Reducing the Renal Retention of Radioligands

Pharmaceuticals
Targeted radionuclide therapy (TRT) is an emerging field and has the potential to become a major pillar in effective cancer treatment. Several pharmaceuticals are already in routine use for treating cancer, and there is still a high potential for new ...
Kim E. de Roode, Lieke Joosten, Martin Behe   +2 more
doaj   +1 more source

Production of Diagnostic and Therapeutic Radionuclides with Uranium and Thorium Molten Salt Fuel Cycles

Journal of Nuclear Engineering
Targeted radionuclide therapy (TRT) is an innovative and flexible approach for treating various forms of cancer, enabling selective delivery of cytotoxic radiation to cancerous cells while minimizing damage to healthy tissue.
C. Erika Moss, Ondrej Chvala, Donny Hartanto   +2 more
doaj   +1 more source