Results 71 to 80 of about 4,214,171 (152)

FAPI in radionuclide theranostics: toward a new emerging paradigm for tumor management

肿瘤影像学
Radionuclide imaging targeting fibroblast activation protein inhibitor (FAPI) has shown notable advantages in the early diagnosis and staging of various tumors.
Ying DING, Hui YANG
doaj  

Continuous β− particle exposure: A study of DNA damage in ex vivo peripheral blood mononuclear cells irradiation with Radioiodine

Clinical and Translational Radiation Oncology
Background and purpose: Targeted radionuclide therapy (TRT) is a promising cancer treatment, but insufficient knowledge of the biological dose–response relationships limits its efficacy.
Laura Mazzitelli-Fuentes, Lara Negrin, Virginia Venier, Humberto Romano, Lucia Pereira, Jerónimo Leberle, Maria Soledad Ausas, Ananya Choudhury, Luisa V. Biolatti   +8 more
doaj   +1 more source

Low-dose targeted radionuclide therapy synergizes with CAR T cells and enhances tumor response

Frontiers in Immunology
Ionizing radiation has garnered considerable attention as a combination partner for immunotherapy due to its potential immunostimulatory effects. In contrast to the more commonly used external beam radiation, we explored the feasibility of combining ...
Yanping Yang, Yanping Yang, Yogindra Vedvyas, Yogindra Vedvyas, Yago Alcaina, Ju Y. Son, Irene M. Min, Irene M. Min, Moonsoo M. Jin, Moonsoo M. Jin   +9 more
doaj   +1 more source

Strategies for specific multimodal imaging of cancer-associated fibroblasts and applications in theranostics of cancer

Materials Today Bio
Fibroblast activating protein (FAP) is up-regulated in cancer-associated fibroblasts (CAFs) of more than 90 % of tumor microenvironment and also highly expressed on the surface of multiple tumor cells like glioblastoma, which can be used as a specific ...
Li Wen, Chengxue He, Yanhui Guo, Nina Zhou, Xiangxi Meng, Yuwen Chen, Cheng Ma, Hua Zhu, Zhi Yang, Lei Xia   +9 more
doaj   +1 more source

In vitro and ex vivo evaluation of preclinical models for FAP-targeted theranostics: differences and relevance for radiotracer evaluation

EJNMMI Research
Background Fibroblast activation protein (FAP) is an attractive target for cancer theranostics. Although FAP-targeted nuclear imaging demonstrated promising clinical results, only sub-optimal results are reported for targeted radionuclide therapy (TRT ...
Circe D. van der Heide, Joana D. Campeiro, Eline A. M. Ruigrok, Lilian van den Brink, Shashikanth Ponnala, Shawn M. Hillier, Simone U. Dalm   +6 more
doaj   +1 more source

ISEV2025 Abstract Book

Journal of Extracellular Vesicles, Volume 14, Issue S1, October 2025.
wiley   +1 more source

212Pb in targeted radionuclide therapy: a review

EJNMMI Radiopharmacy and Chemistry
Background The selective delivery of α-emitting radionuclides is emerging as a highly effective form of cancer therapy. With a short range and high cytotoxicity, α-particles can selectively kill cancerous cells whilst minimising harm to surrounding ...
Jarred Michael Scaffidi-Muta, Andrew David Abell   +1 more
doaj   +1 more source

Implementing Ac-225 labelled radiopharmaceuticals: practical considerations and (pre-)clinical perspectives

EJNMMI Radiopharmacy and Chemistry
Background In the past years, there has been a notable increase in interest regarding targeted alpha therapy using Ac-225, driven by the observed promising clinical anti-tumor effects. As the production and technology has advanced, the availability of Ac-
Eline L. Hooijman, Valery Radchenko, Sui Wai Ling, Mark Konijnenberg, Tessa Brabander, Stijn L. W. Koolen, Erik de Blois   +6 more
doaj   +1 more source

Poster Sessions

HemaSphere, Volume 9, Issue S1, June 2025.
wiley   +1 more source

Comparison of the dosimetry and cell survival effect of 177Lu and 161Tb somatostatin analog radiopharmaceuticals in cancer cell clusters and micrometastases

EJNMMI Physics
Background 177Lu-based radiopharmaceuticals (RPs) are the most used for targeted radionuclide therapy (TRT) due to their good response rates. However, the worldwide availability of 177Lu is limited. 161Tb represents a potential alternative for TRT, as it
Laura De Nardo, Sara Santi, Anna Dalla Pietà, Guillermina Ferro-Flores, Erika Azorín-Vega, Emma Nascimbene, Vito Barbieri, Alessandra Zorz, Antonio Rosato, Laura Meléndez-Alafort   +9 more
doaj   +1 more source