Results 51 to 60 of about 1,721,954 (363)

Clinical actionability of comprehensive genomic profiling for management of rare or refractory cancers [PDF]

, 2016
Background. The frequency with which targeted tumor sequencing results will lead to implemented change in care is unclear. Prospective assessment of the feasibility and limitations of using genomic sequencing is critically important. Methods.
Aisner, Joseph, Ali, Siraj M., Belyi, Vladimir, Bertino, Joseph R., Chan, Chang S., Chen, Suzie, DiPaola, Robert S., Foran, David, Ganesan, Shridar, Glod, John, Goodell, Lauri, Hirshfield, Kim M., Kaufman, Howard, Mehnert, Janice, Miller, Vincent A., Moss, Rebecca A., Murphy, Susan, Palma, Norma A., Poplin, Elizabeth, Rodriguez-Rodriguez, Lorna, Ross, Jeffrey S., Stein, Mark N., Stephens, Philip J., Sun, James X., Tan, Antoinette R., Tolkunov, Denis, Vazquez, Alexei, Vig, Hetal, Yelensky, Roman, Zhong, Hua   +29 more
core   +1 more source

Characterization and Mechanistic Studies of a Novel Melanoma-Targeting Construct Containing IκBa for Specific Inhibition of Nuclear Factor-κB Activity

Neoplasia: An International Journal for Oncology Research, 2010
The transcription factor nuclear factor-κB (NF-κB) is a central mediator of growth and homeostasis for both normal and neoplastic cells. IκBα is the natural intracellular inhibitor of NF-κB and can effectively complex with and thereby inhibit the ...
Hong Zhou, Yuying Liu, Lawrence H. Cheung, Sehoon Kim, Weihe Zhang, Khalid A. Mohamedali, Preetha Anand, Walter N. Hittelman, Bharat B. Aggarwal, Michael G. Rosenblum   +9 more
doaj   +1 more source

Recent Advancements of Artificial Intelligence in Particle Therapy [PDF]

arXiv, 2022
We are in a golden age of progress in artificial intelligence (AI). Radiotherapy, due to its technology-intensive nature as well as direct human-machine interactions, is perfectly suited for benefitting from AI to enhance accuracy and efficiency. Over the past few years, a vast majority of AI research have already been published in the field of photon ...
arxiv  

Cancer stem cells in prostate cancer: implications for targeted therapy [PDF]

, 2017
Prostate cancer (PCa) is the most frequently diagnosed cancer in men and the second most common cause of cancer-related mortality among men in the developed world.
Castelo-Branco, Pedro, Domingos, Célia, Figueiredo, Arnaldo, Hamilton, Robert, Leao, Ricardo, Tabori, Uri   +5 more
core   +1 more source

Imaging in Radiotherapy [PDF]

CERN Yellow Report CERN-2017-004-SP pp. 71-78, 2018
With the continued evolution of modern radiation therapy towards high precision delivery of high therapeutic doses to the tumour while optimally sparing surrounding healthy tissue, imaging becomes a crucial component to identify the intended target, properly position it at the treatment site and, in more advanced research applications, visualize the ...
arxiv   +1 more source

Characterization of pixelated silicon detectors for daily quality assurance measurements in proton therapy [PDF]

, 2022
The advanced imaging and delivery techniques in proton therapy allow conformal high-dose irradiation of the target volume with high accuracy using pencil beam scanning or beam shaping apertures. These irradiation methods increasingly include small radiation fields with large dose gradients, which require detector systems with high spatial resolution ...
arxiv   +1 more source

HOX and PBX gene dysregulation as a therapeutic target in glioblastoma multiforme

BMC Cancer, 2022
Background Glioblastoma multiforme (GBM) is the most common high-grade malignant brain tumour in adults and arises from the glial cells in the brain. The prognosis of treated GBM remains very poor with 5-year survival rates of 5%, a figure which has not ...
Einthavy Arunachalam, William Rogers, Guy R. Simpson, Carla Möller-Levet, Gemma Bolton, Mohammed Ismael, Christopher Smith, Karl Keegen, Izhar Bagwan, Tim Brend, Susan C. Short, Bangxing Hong, Yoshihiro Otani, Balveen Kaur, Nicola Annels, Richard Morgan, Hardev Pandha   +16 more
doaj   +1 more source

Bone-Targeted Therapy [PDF]

Geburtshilfe und Frauenheilkunde, 2015
Bisphosphonates and denosumab are well established components of the therapy for osteoporosis and osseous metastases. Their relevance in the adjuvant situation for breast cancer patients is being discussed in part controversially due to the heterogeneous nature of the available data.
J. Salmen, M. Banys-Paluchowski, Tanja Fehm   +2 more
openaire   +3 more sources

Molecular pathogenesis and targeted therapy of sporadic pancreatic neuroendocrine tumors [PDF]

, 2015
Over the past few years, knowledge regarding the molecular pathology of sporadic pancreatic neuroendocrine tumors (PNETs) has increased substantially, and a number of targeted agents have been tested in clinical trials in this tumor type.
Ahn, Balogh, Bergers, Berruti, Capurso, Capurso, Carew, Castellano, Chamberlain, Chan, Chan, Chen, Clynes, Corbo, Corbo, Couvelard, De Wilde, Di Florio, Di Florio, Di Florio, Fazio, Fendrich, Gaur, Gurung, Han, Heaphy, Heaphy, Hobday, Hopfner, House, Jacinto, Jensen, Jiao, Karnik, Karnik, Komori, Kulke, Laplante, Loewith, Lovejoy, Luzi, Marinoni, Marion-Audibert, Mendel, Meric-Bernstam, Missiaglia, Mocellin, Panzuto, Papouchado, Passacantilli, Perren, Pàez-Ribes, Raymond, Sarbassov, Scoazec, Shah, Shi, Tang, Vinagre, Wang, Yang, Yao, Yuan, Zhang, Zhang   +64 more
core   +1 more source

Resistance is futile: overcoming resistance to targeted therapies in lung adenocarcinoma. [PDF]

, 2017
The advent of genomics has led to the identification of specific "driver" mutations in oncogenic kinases, and the development of targeted small molecule inhibitors to block their tumor-driving functions.
Bivona, Trever G, Neel, Dana S
core   +1 more source