Results 71 to 80 of about 10,998,800 (355)

Characterization and Mechanistic Studies of a Novel Melanoma-Targeting Construct Containing IκBa for Specific Inhibition of Nuclear Factor-κB Activity

Neoplasia: An International Journal for Oncology Research, 2010
The transcription factor nuclear factor-κB (NF-κB) is a central mediator of growth and homeostasis for both normal and neoplastic cells. IκBα is the natural intracellular inhibitor of NF-κB and can effectively complex with and thereby inhibit the ...
Hong Zhou, Yuying Liu, Lawrence H. Cheung, Sehoon Kim, Weihe Zhang, Khalid A. Mohamedali, Preetha Anand, Walter N. Hittelman, Bharat B. Aggarwal, Michael G. Rosenblum   +9 more
doaj   +1 more source

Long Non-coding RNA BTG3-7:1 and JUND Co-regulate C21ORF91 to Promote Triple-Negative Breast Cancer Progress

Frontiers in Molecular Biosciences, 2021
BackgroundTriple-negative breast cancer (TNBC) is a type of highly invasive breast cancer with poor prognosis. Recently, massive data reveal that long non-coding RNAs (lncRNAs) play important roles in cancer progress.
Zheng Dan, He Xiujing, Luo Ting, Zhong Xiaorong, Zheng Hong, Yang Jiqiao, Li Yanchu, Jing Jing   +7 more
doaj   +1 more source

A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers. [PDF]

, 2016
mTOR inhibition has emerged as a promising strategy for head and neck squamous cell carcinomas (HNSCC) treatment. However, most targeted therapies ultimately develop resistance due to the activation of adaptive survival signaling mechanisms limiting the ...
Amornphimoltham, Panomwat, Califano, Joseph A, Callejas-Valera, Juan Luis, Cohen, Ezra E, Gutkind, J Silvio, Iglesias-Bartolomé, Ramiro, Lippman, Scott M, Luo, Ji, Molinolo, Alfredo A, Wang, Zhiyong, Yamaguchi, Kosuke   +10 more
core   +1 more source

Tumor biomarkers for diagnosis, prognosis and targeted therapy

Signal Transduction and Targeted Therapy
Tumor biomarkers, the substances which are produced by tumors or the body’s responses to tumors during tumorigenesis and progression, have been demonstrated to possess critical and encouraging value in screening and early diagnosis, prognosis prediction,
Yuee Zhou, Lei Tao, Jia-Hui Qiu, Jing Xu, Xinyu Yang, Yu Zhang, Xinyu Tian, Xinqi Guan, Xiaobo Cen, Yinglan Zhao   +9 more
semanticscholar   +1 more source

Potential novel therapy targets in neuroendocrine carcinomas of the breast [PDF]

, 2018
Neuroendocrine carcinoma (NEC) of the breast is a rare, special type of breast cancer, reportedly constituting 2% to 5% of all breast cancers. Although breast NEC does not have a specific targeted therapy, several new targeted therapies based on specific
Contreras, Elma, Florento, Elena, Gatalica, Zoran, Palazzo, Juan, Sanati, Souzan, Swensen, Jeffrey, Vranic, Semir, Xiu, Joanne   +7 more
core   +2 more sources

Targeted therapy: An elusive cancer target [PDF]

Nature, 2016
Advanced tumours may have met their match with new drugs, but why have these treatments proved ineffective at stopping early-stage tumours from coming back?
openaire   +2 more sources

Update on Targeted Therapy and Immunotherapy for Metastatic Colorectal Cancer

Cells
Metastatic colorectal cancer remains a deadly malignancy and is the third leading cause of cancer-related death. The mainstay of treatment for metastatic colorectal cancer is chemotherapy, but unfortunately, even with recent progress, overall survival is
Patrick W Underwood, Samantha M Ruff, T. Pawlik   +2 more
semanticscholar   +1 more source

Signal pathways of melanoma and targeted therapy

Signal Transduction and Targeted Therapy, 2021
Melanoma is the most lethal skin cancer that originates from the malignant transformation of melanocytes. Although melanoma has long been regarded as a cancerous malignancy with few therapeutic options, increased biological understanding and ...
Weinan Guo, Huina Wang, Chunying Li
semanticscholar   +1 more source

Sculpting the tumour microenvironment by combining radiotherapy and ATR inhibition for curative-intent adjuvant immunotherapy

Nature Communications
The combination of radiotherapy/chemoradiotherapy and immune checkpoint blockade can result in poor outcomes in patients with locally advanced head and neck squamous cell carcinoma (HNSCC).
Emmanuel C. Patin, Pablo Nenclares, Charleen Chan Wah Hak, Magnus T. Dillon, Anton Patrikeev, Martin McLaughlin, Lorna Grove, Shane Foo, Heba Soliman, Joao P. Barata, Joanna Marsden, Holly Baldock, Jim Gkantalis, Victoria Roulstone, Joan Kyula, Amy Burley, Lisa Hubbard, Malin Pedersen, Simon A. Smith, Eleanor Clancy-Thompson, Alan A. Melcher, Masahiro Ono, Antonio Rullan, Kevin J. Harrington   +23 more
doaj   +1 more source

MMP9: A Tough Target for Targeted Therapy for Cancer

Cancers, 2022
Simple Summary MMP9, due to its proteolytic activity, plays a key role in tumorigenesis by regulating migration, epithelial-to-mesenchymal transition and survival of cancer cells, induction of immune response, angiogenesis and formation of tumor ...
K. Augoff, A. Hryniewicz-Jankowska, R. Taboła, Kamilla Stach   +3 more
semanticscholar   +1 more source