Results 111 to 120 of about 5,915,409 (225)

N‐Amino Peptide–Graphene Quantum Dot Loaded Small Extracellular Vesicles for Targeted Therapy of Tauopathies

Advanced NanoBiomed Research
Tauopathies, a group of neurodegenerative disorders, are characterized by the abnormal aggregation of tau proteins into neurofibrillary tangles, driving synaptic dysfunction, neuronal loss, and disease progression through tau aggregate propagation ...
Runyao Zhu, Gaeun Kim, Benjamin H. Rajewski, Isaac J. Angera, Juan R. Del Valle, Yichun Wang   +5 more
doaj   +1 more source

The role of A β and Tau proteins in Alzheimer's disease: a mathematical model on graphs. [PDF]

J Math Biol, 2023
Bertsch M, Franchi B, Tesi MC, Tora V.
europepmc   +1 more source

Electrochemical Immunosensors Developed for Amyloid-Beta and Tau Proteins, Leading Biomarkers of Alzheimer's Disease. [PDF]

Biosensors (Basel), 2023
Sharma A, Angnes L, Sattarahmady N, Negahdary M, Heli H.   +4 more
europepmc   +1 more source

Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation. [PDF]

, 2019
Molecular tweezers (MTs) are supramolecular host molecules equipped with two aromatic pincers linked together by a spacer (Gakh, 2018). They are endowed with fascinating properties originating from their ability to hold guests between their aromatic ...
Bitan, Gal, Hadrovic, Inesa, Klärner, Frank-Gerrit, Rebmann, Philipp, Schrader, Thomas   +4 more
core  

Cerebrospinal fluid neuronal pentraxin levels are associated with tau pathology via microglia–astrocyte signaling in alzheimer’s disease

Journal of Neuroinflammation
Background Recent studies have reported that Neuronal Pentraxin 2 (NPTX2), a synapse-associated protein, can significantly predict the progression of cognitive decline.
Zihao Zhang, Xin Chen, Zehu Sheng, Na Jiang, Wen-Quan Zou   +4 more
doaj   +1 more source

Plasma tau proteins for the diagnosis of mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis. [PDF]

Front Aging Neurosci, 2022
Chen L, Niu X, Wang Y, Lv S, Zhou X, Yang Z, Peng D.   +6 more
europepmc   +1 more source

Tripartite Relationship Among Synaptic, Amyloid, and Tau Proteins: An In Vivo and Postmortem Study. [PDF]

Neurology, 2021
Casaletto KB, Zetterberg H, Blennow K, Brinkmalm A, Honer W, Schneider JA, Bennett DA, Djukic N, You M, Weiner-Light S, Fonseca C, Miller BL, Kramer J.   +12 more
europepmc   +1 more source

Tau induces inflammasome activation and microgliosis through acetylating NLRP3

Clinical and Translational Medicine
Background Alzheimer's disease (AD) and related Tauopathies are characterised by the pathologically hyperphosphorylated and aggregated microtubule‐associated protein Tau, which is accompanied by neuroinflammation mediated by activated microglia. However,
Lun Zhang, Yongkang Gai, Yushuang Liu, Dongli Meng, Yi Zeng, Yong Luo, Huiliang Zhang, Zhuoqun Wang, Mengzhe Yang, Yunfan Li, Yi Liu, Yiwen Lai, Jiayu Yang, Gang Wu, Yu Chen, Jingtan Zhu, Shaojun Liu, Tingting Yu, Ji Zeng, Jianzhi Wang, Dan Zhu, Xiaochuan Wang, Xiaoli Lan, Rong Liu   +23 more
doaj   +1 more source

14-3-3 proteins—a moonlight protein complex with therapeutic potential in neurological disorder: in-depth review with Alzheimer’s disease

Frontiers in Molecular Biosciences
Alzheimer’s disease (AD) affects millions of people worldwide and is a gradually worsening neurodegenerative condition. The accumulation of abnormal proteins, such as tau and beta-amyloid, in the brain is a hallmark of AD pathology.
Gholamareza Abdi, Mukul Jain, Mukul Jain, Nil Patil, Nil Patil, Bindiya Upadhyay, Nigam Vyas, Nigam Vyas, Manish Dwivedi, Radhey Shyam Kaushal, Radhey Shyam Kaushal   +10 more
doaj   +1 more source

Insulin Signaling Disruption and INF-γ Upregulation Induce Aβ_1-42 and Hyperphosphorylated-Tau Proteins Synthesis and Cell Death after Paraquat Treatment of Primary Hippocampal Cells. [PDF]

Chem Res Toxicol, 2022
Abascal ML, Sanjuan J, Moyano P, Sola E, Flores A, Garcia JM, Garcia J, Frejo MT, Del Pino J.   +8 more
europepmc   +1 more source