Results 211 to 220 of about 5,828,673 (370)

Pigment Epithelium‐Derived Factor Deficiency Impairs Hippocampal Glutamate Homeostasis and Cognitive Function by Downregulating Astrocytic GLT‐1

Advanced Science, EarlyView.
The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi, Qi‐Long Tang, Jin‐Hong Wang, Yan‐Lan Long, Sai‐Feng Zhao, Zhen Zhao, Wan‐Ting Xie, Zi‐Ming Li, Hao‐Ming Lu, Tian‐Xiao Gao, Zhen‐Zhen Fang, Ti Zhou, Bo‐Xing Li, Xia Yang, Guo‐Quan Gao, Wei‐Wei Qi   +15 more
wiley   +1 more source

Phosphorylation of recombinant tau by cAMP-dependent protein kinase. Identification of phosphorylation sites and effect on microtubule assembly.

, 1993
Clay W. Scott, Russell C. Spreen, Joseph L. Herman, Fungyi Chow, Matt Davison, J D Young, C.B. Caputo   +6 more
openalex   +1 more source

Interleukin-1 Promotes Expression and Phosphorylation of Neurofilament and tau Proteins in Vivo [PDF]

, 2000
Jin G. Sheng, Shujuan Zhu, Richard A. Jones, W. Sue T. Griffin, Robert E. Mrak   +4 more
openalex   +1 more source

A Prion‐Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing

Advanced Science, EarlyView.
This study discoveries that EBV EBNA1 behaves as a prion‐like protein, verified using cell‐based assays and the Saccharomyces cerevisiae Sup35p prion identification system. The prion‐like domain of EBNA1 drives liquid–liquid phase separation. EBNA1 interacts with the splicing factor SRSF1 to regulate the expression of the SRRM1 splicing isoforms ...
Xiaoyue Zhang, Zhengshuo Li, Run Zheng, Xiang Zheng, Jia Wang, Can Liu, Yangge Wu, Yuqing Wen, Chunlin Ou, Songqing Fan, Chenxiao Xu, Junrui Tian, Qun Yan, Hao Nan, Xiaodong Xu, Hui Wang, Qiu Peng, Jian Ma   +17 more
wiley   +1 more source

Assessment of Amyloid Forming Tendency of Peptide Sequences from Amyloid Beta and Tau Proteins Using Force-Field, Semi-Empirical, and Density Functional Theory Calculations. [PDF]

Int J Mol Sci, 2021
Muvva C, Murugan NA, Subramanian V.
europepmc   +1 more source

Tau regulates the localization and function of End‐binding proteins 1 and 3 in developing neuronal cells

Journal of Neurochemistry, 2015
C. L. Sayas, Elena Tortosa, F. Bollati, Sacnicte Ramirez-Rios, I. Arnal, J. Ávila   +5 more
semanticscholar   +1 more source

Capsaicin Alleviates Autophagy‐Lysosomal Dysfunction via PPARA‐Mediated V‐ATPase Subunit ATP6V0E1 Signaling in 3xTg‐AD Mice

Advanced Science, EarlyView.
Capsaicin enhances lipid metabolism, reduces lipid deposition, and alleviates AD‐related pathologies. Capsaicin activates PPARA, promoting the expression of PPAR signaling pathway‐related genes and accelerating lipid metabolism. Capsaicin upregulates ATP6V0E1‐V‐ATPase‐mediated lysosomal acidification, enhancing lipid droplet clearance. PPARA is the key
Haitao Yu, Jia Chen, Fangzhou Wang, Dongdong Jia, Shuguang Bi, Yuming Mao, Yu‐qi Zhang, Tian‐long Gao, Liu Yang, Jia‐xu Du, Zi‐han Zhou, Xi‐Chen Zhu, Gao‐shang Chai   +12 more
wiley   +1 more source

Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau.

, 1992
S G Greenberg, Peter Davies, Jay Schein, Lester I. Binder   +3 more
openalex   +1 more source

Interaction of Neuronal Cdc2-like Protein Kinase with Microtubule-associated Protein Tau [PDF]

, 2000
Kazuya Sobue, Alka Agarwal-Mawal, Wěi Li, Wei Sun, Yutaka Miura, Hemant K. Paudel   +5 more
openalex   +1 more source

Physiological pH Transition‐Driven Protein Corona Dynamics Regulate Cellular Uptake and Inflammatory Responses of Silica Nanoparticles

Advanced Science, EarlyView.
Physiological pH transitions modulate protein corona dynamics on nanoparticles, altering their cellular uptake and inflammatory responses. Acidic pHs enhance protein adsorption, induce structural changes, and promote cellular uptake. Simultaneously, inflammatory responses are reduced due to altered protein composition, including decreased ...
Yuting Ge, Fangqin Fu, Yu Gao, Tianchang He, Volker Mailänder, Daniel Crespy, Katharina Landfester, Shuai Jiang   +7 more
wiley   +1 more source