Results 221 to 230 of about 5,828,673 (370)

Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain.

Archives of Neurology, 2009
T. Tapiola, I. Alafuzoff, S. Herukka, L. Parkkinen, P. Hartikainen, H. Soininen, T. Pirttilä   +6 more
semanticscholar   +1 more source

Endothelial BMP6 Drives Hemodynamic‐Dependent VSMCs Calcification in Carotid Atherosclerosis

Advanced Science, EarlyView.
The study demonstrates that endothelial cell (EC)‐derived BMP6 promotes the osteogenic differentiation of vascular smooth muscle cells (VSMCs) through cell‐cell interactions. Additionally, the researchers preliminarily explore the driving effect of hemodynamic factors on BMP6‐induced calcification and reveal the regulatory role of KLF4 on BMP6.
Shen Li, Shuang Cao, Peipei Li, Feng Zhang, Gangfeng Ren, Xin Wang, Jiawei Zhao, Chen Liu, Yuan Gao, Jie Xu, Yongjun Wang, Zongping Xia, Yuming Xu   +12 more
wiley   +1 more source

PEG-Ceramide Nanomicelles Induce Autophagy and Degrade Tau Proteins in N2a Cells. [PDF]

Int J Nanomedicine, 2020
Gao J, Chen X, Ma T, He B, Li P, Zhao Y, Ma Y, Zhuang J, Yin Y.   +8 more
europepmc   +1 more source

Mutation-dependent aggregation of tau protein and its selective depletion from the soluble fraction in brain of P301L FTDP-17 patients [PDF]

, 2000
Patrizia Rizzu
openalex   +1 more source

SENP6 Maintains Mitochondrial Homeostasis by Regulating Mitochondrial Protein Import Through deSUMOylation of TOM40

Advanced Science, EarlyView.
SUMOylation regulates mitochondrial processes, but its impact on protein import remains unclear. TOM40 is identified, a mitochondrial outer membrane channel protein, as a substrate of deSUMOylase SENP6. TOM40 SUMOylation disrupts outer membrane complex assembly, inhibits protein import, and compromises mitochondrial homeostasis.
Liubing Hu, Jianshuang Li, Haolin Guo, Lei Su, Peina Dong, Juan Huang, Yanyan Liu, Xinjie Liu, Zhenhuan Luo, Wei Xiong, Zhenyu Ju, Qinghua Zhou, Hao Wang, Wenjun Wang   +13 more
wiley   +1 more source

The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans

Science, 2019
Jerrah K Holth, Sarah K. Fritschi, Chanung Wang, N. Pedersen, J. Cirrito, Thomas E Mahan, M. B. Finn, Melissa Manis, Joel C Geerling, P. Fuller, B. Lucey, D. Holtzman   +11 more
semanticscholar   +1 more source

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation

Advanced Science, EarlyView.
LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao, Bin Sun, Pengju Wei, Yingying Sun, Qianyan He, Kejia Zhang, Jun Lu, Shoujun Zhu, Yi Yang, Zhenni Guo   +9 more
wiley   +1 more source

Correction: The Role of Alpha-Synuclein and Tubulin-Associated Unit (Tau) Proteins in the Diagnosis, Prognosis, and Treatment of Parkinson's Disease: A Systematic Review. [PDF]

Cureus
Lin YM, Banoth D, Wali MH, Bekova K, Abdulla N, Gurugubelli S, Khan S.   +6 more
europepmc   +1 more source

The Regulatory Ser262 of Microtubule-associated Protein Tau Is Phosphorylated by Phosphorylase Kinase

, 1997
Hemant K. Paudel
openalex   +1 more source

N^tau;-methylhistidine excretion is a valid index of myofibrillar protein breakdown in the guineapig (Cavia porcellus) [PDF]

, 2001
Paul F. Rogers, Tomáš Fürst
openalex   +1 more source