Results 241 to 250 of about 5,828,673 (370)

Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease [PDF]

, 2001
Sophie Leclerc, Matthieu Garnier, Ralph Hoessel, Doris Marko, James Bibb, Gretchen L. Snyder, Paul Greengard, Jacek Biernat, Yong‐Zhong Wu, Eva‐Maria Mandelkow, Gerhard Eisenbrand, Laurent Meijer   +11 more
openalex   +1 more source

Igfbp2 Downregulation in PVT‐CeA Glutamatergic Circuits Drives Neonatal Anesthesia‐Induced Fear Memory Deficits

Advanced Science, EarlyView.
Repeated neonatal sevoflurane exposure impairs adolescent fear memory through Igfbp2 downregulation in paraventricular thalamus‐central amygdala glutamatergic projections. Restoring Igfbp2 or activating this circuit rescues memory deficits, neuronal excitability, and spine density, identifying a precise molecular target for preventing anesthesia ...
Weiming Zhao, Ke Peng, Baojian Zhao, Xiaowen Meng, Gang Wang, Hanbing Xu, Li Deng, Xisheng Shan, Yichan Wang, Qiya Xu, Yanan Gao, Ruixia Weng, Hong Liu, Jin Tao, Huayue Liu, Shaoyong Song, Fuhai Ji   +16 more
wiley   +1 more source

Klotho null mutation leads to retinal degeneration characterized by functional impairment, gliosis, and deposition of amyloid-beta and hyperphosphorylated tau proteins. [PDF]

PLoS One
Chen ZJ, Wu CY, Hsiao FY, Ma JC, Lai G, Chang HH, Lin DP.   +6 more
europepmc   +1 more source

The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bɛ at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase [PDF]

, 2001
Yvonne L. Woods, Philip Cohen, Walter Becker, Ross Jakes, Michel Goedert, Xuemin Wang, Christopher G. Proud   +6 more
openalex   +1 more source

Quantitative Profiling of Nanoscopic Protein Aggregates Reveals Specific Fingerprint of TDP‐43‐Positive Assemblies in Motor Neuron Disease

Advanced Science, EarlyView.
Single‐molecule fluorescence microscopy is combined with proteomic profiling to fingerprint the morphology and composition of TDP‐43 protein aggregates found in post‐mortem motor neuron disease brain tissues. Aggregate fingerprints can distinguish disease from control donors and detect unexpected TDP‐43 pathology in SOD1‐MND.
Dezerae Cox, Melanie Burke, Sara Milani, Matthew A White, Fergal M Waldron, Dorothea Böken, Evgeniia Lobanova, Jemeen Sreedharan, Jenna M Gregory, David Klenerman   +9 more
wiley   +1 more source

Morphometric Similarity Patterning of Amyloid-β and Tau Proteins Correlates with Transcriptomics in the Alzheimer's Disease Continuum. [PDF]

Int J Mol Sci
Brusini L, Dolci G, Pini L, Cruciani F, Pizzagalli F, Provero P, Menegaz G, Boscolo Galazzo I, Alzheimer’s Disease Neuroimaging Initiative.   +8 more
europepmc   +1 more source

NADPH Oxidase Inhibition Promotes Brain Resilience by Attenuating Tauopathy and Neuroinflammation in Alzheimer's Disease

Advanced Science, EarlyView.
CRB‐2131, as a novel Nox inhibitor, suppresses brain oxidation, tauopathy, and neuro‐inflammation, thereby preventing death of mature neurons and promoting regeneration of immature neurons. Ultimately, this fosters a resilient brain and protects cognition.
Jihyeon Lee, Seunghwan Sim, Yinglan Jin, Hyejun Park, Eun Young Byeon, Su Jin Kim, Sujin Yun, Hye Eun Lee, Da Un Jeong, Jung Min Suh, In Hye Lee, Ho‐Young Lee, Yongseok Choi, Yun Soo Bae   +13 more
wiley   +1 more source

The Role of Alpha-Synuclein and Tubulin-Associated Unit (Tau) Proteins in the Diagnosis, Prognosis, and Treatment of Parkinson's Disease: A Systematic Review. [PDF]

Cureus
Lin YM, Banoth D, Wali MH, Bekova K, Abdulla N, Gurugubelli S, Khan S.   +6 more
europepmc   +1 more source

Loss of Hepatic Angiotensinogen Attenuates Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
Increased hepatic angiotensinogen (AGT) abundance leads to cardiac diastolic dysfunction via the AngII‐independent pathway. Liver‐derived AGT is internalized by LRP2 in cardiac endothelial cells, subsequently contributing to myocardial diastolic dysfunction by suppressing microvascular angiogenesis via inhibiting the GATA2/Pim3 pathway.
Zetao Heng, Min Hong, Zhaocai Zhang, Ximing Ye, Jianan Zhou, Wentao Wu, Jiabing Rong, Yinchuan Xu   +7 more
wiley   +1 more source

Pilot Study of the Total and Phosphorylated Tau Proteins in Early-Stage Multiple Sclerosis. [PDF]

Medicina (Kaunas)
Masiulienė I, Pampuščenko K, Žemgulytė G, Bilskienė D, Borutaitė V, Balnytė R.   +5 more
europepmc   +1 more source