Results 41 to 50 of about 5,828,673 (370)
Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity
Cell Reports, 2016 Summary: Dendritic mislocalization of microtubule associated protein tau is a hallmark of tauopathies, but the role of dendritic tau is unknown. We now report that tau interacts with the RNA-binding protein (RBP) TIA1 in brain tissue, and we present the ...
Tara Vanderweyde +15 more
doaj +1 more source
Tau drives translational selectivity by interacting with ribosomal proteins
Acta Neuropathologica, 2019 There is a fundamental gap in understanding the consequences of tau–ribosome interactions. Tau oligomers and filaments hinder protein synthesis in vitro, and they associate strongly with ribosomes in vivo.
Shon A. Koren +10 more
semanticscholar +1 more source
Tau Protein Interaction Partners and Their Roles in Alzheimer’s Disease and Other Tauopathies
International Journal of Molecular Sciences, 2021 Tau protein plays a critical role in the assembly, stabilization, and modulation of microtubules, which are important for the normal function of neurons and the brain.
J. Šinský +2 more
semanticscholar +1 more source
The Neurotoxic Role of Extracellular Tau Protein [PDF]
International Journal of Molecular Sciences, 2018 Tauopathies are a class of neurodegenerative diseases associated with the microtubule-associated protein tau, with Alzheimer’s disease (AD) being the most prevalent related disorder. Neurofibrillary tangles (NFTs) are one of the neuropathological hallmarks present in the brains of AD patients.
Laura de Diego-García +5 more
openaire +7 more sources
NMR Studies of Tau Protein in Tauopathies [PDF]
Frontiers in Molecular Biosciences, 2021 Tauopathies, including Alzheimer’s disease (AD), are the most troublesome of all age-related chronic conditions, as there are no well-established disease-modifying therapies for their prevention and treatment. Spatio-temporal distribution of tau protein pathology correlates with cognitive decline and severity of the disease, therefore, tau protein has ...
Kristine Kitoka +8 more
openaire +5 more sources
DnaJC7 specifically regulates tau seeding
eLife, 2023 Neurodegenerative tauopathies are caused by accumulation of toxic tau protein assemblies. This appears to involve template-based seeding events, whereby tau monomer changes conformation and is recruited to a growing aggregate.
Valerie Ann Perez +7 more
doaj +1 more source
Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in alzheimer’s disease and parkinson’s disease [PDF]
, 2017 Alzheimer's disease and Parkinson's disease are two common neurodegenerative diseases of the elderly people that have devastating effects in terms of morbidity and mortality.
Chakrabarti, S. +3 more
core +3 more sources
Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB
EMBO Molecular Medicine, 2014 Accumulating evidence implicates impairment of the autophagy‐lysosome pathway in Alzheimer's disease (AD). Recently discovered, transcription factor EB (TFEB) is a molecule shown to play central roles in cellular degradative processes.
V. A. Polito +12 more
semanticscholar +1 more source
The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease [PDF]
, 2012 A significant amount of evidence suggests that the p38-mitogen-activated protein kinase (MAPK) signalling cascade plays a crucial role in synaptic plasticity and in neurodegenerative diseases.
Corrêa, Sônia A. L. +1 more
core +3 more sources
Acta Neuropathologica, 2020 Tau and amyloid beta (Aβ) are the prime suspects for driving pathology in Alzheimer’s disease (AD) and, as such, have become the focus of therapeutic development.
Sarah A. Kent +2 more
semanticscholar +1 more source