Results 91 to 100 of about 12,857 (194)

Toxic mechanisms of amyloid oligomers and therapeutic strategies

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova, Carmelo La Rosa, Ayyalusamy Ramamoorthy   +2 more
wiley   +1 more source

Tau and tauopathies across primate species: implications for modeling neurodegenerative disorders

Frontiers in Aging Neuroscience
Tauopathies are neurodegenerative disorders characterized by the abnormal accumulation and aggregation of hyperphosphorylated tau protein. They can be primary or secondary depending on whether tau inclusions are the predominant pathology (e.g ...
Julia C. Colwell, Julia C. Colwell, Marina E. Emborg, Marina E. Emborg, Marina E. Emborg   +4 more
doaj   +1 more source

Recent Insights Into Alzheimer's Disease: Advances in Pathophysiology and Therapeutic Strategies

Brain Health, Volume 1, Issue 1, 26 March 2026.
ABSTRACT Alzheimer's disease (AD) is a complex neurodegenerative disorder driven by interplay among amyloid‐β (Aβ) plaques, tau neurofibrillary tangles, inflammation and comorbid pathologies. Recent advances in biomarkers and therapeutic approvals have reshaped our understanding of its pathophysiology and treatment landscape.
Jiong Shi, Jeffery Cummings, Jacques Touchon, Bruno Vellas   +3 more
wiley   +1 more source

A decrease in Fkbp52 alters autophagosome maturation and A152T-tau clearance in vivo

Frontiers in Cellular Neuroscience
The failure of the autophagy-lysosomal pathway to clear the pathogenic forms of Tau exacerbates the pathogenesis of tauopathies. We have previously shown that the immunophilin FKBP52 interacts both physically and functionally with Tau, and that a ...
Emilie Lesport, Emilie Lesport, Lucie Commeau, Mélanie Genet, Etienne-Emile Baulieu, Etienne-Emile Baulieu, Marcel Tawk, Julien Giustiniani, Julien Giustiniani   +8 more
doaj   +1 more source

Modulation of Tau Protein Neurotoxic Hallmarks by Novel σ1R Agonists/HDAC Inhibitor Dual‐Acting Compounds

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
This study explores the development of dual‐acting compounds combining σ1R agonists and histone deacetylase inhibitors (HDACi). Key findings include compound 2d and 3a's high affinity for σ1R and favorable pharmacokinetic profile and an in vivo determined σ1R agonist profile by reversing the effect of the σ1R antagonist BD‐1063.
Antonino N. Fallica, Carla Barbaraci, M. Carmen Ruiz‐Cantero, Arianna Scarlatti, Alessandro Coco, Giorgia Giordano, Alfonsina La Mantia, Orazio Prezzavento, Antonio Di Stefano, Ivana Cacciatore, Giacomo Siano, Antonino Cattaneo, Lorella Pasquinucci, Enrique J. Cobos, Cristina Di Primio, Emanuele Amata, Agostino Marrazzo   +16 more
wiley   +1 more source

Tau seeding without tauopathy

Journal of Biological Chemistry
Neurodegenerative tauopathies such as Alzheimer's disease (AD) are caused by brain accumulation of tau assemblies. Evidence suggests tau functions as a prion, and cells and animals can efficiently propagate unique, transmissible tau pathologies. This suggests a dedicated cellular replication machinery, potentially reflecting a normal physiologic ...
Michael S. LaCroix, Efrosini Artikis, Brian D. Hitt, Joshua D. Beaver, Sandi-Jo Estill-Terpack, Kelly Gleason, Carol A. Tamminga, Bret M. Evers, Charles L. White, Byron Caughey, Marc I. Diamond   +10 more
openaire   +2 more sources

Homogenization of Smoluchowski-type equations with transmission boundary conditions

Advanced Nonlinear Studies
In this work, we prove a two-scale homogenization result for a set of diffusion-coagulation Smoluchowski-type equations with transmission boundary conditions.
Franchi Bruno, Lorenzani Silvia
doaj   +1 more source

Tau conformation, distribution and PET imaging correlations in progressive supranuclear palsy. [PDF]

Transl Neurodegener
Dong C, Ma JH, Qiao HW, Tamagnan GD, Chan P, Liu SY.   +5 more
europepmc   +1 more source

Classification of tauopathies from human brain homogenates through salt-modulated tau amplification. [PDF]

Alzheimers Dement
Santambrogio A, Metrick MA, Xu P, Gallagher NCT, Koga S, Ghetti B, Dickson DW, Caughey B, Vendruscolo M.   +8 more
europepmc   +1 more source

A critical appraisal of the link between apolipoprotein E and Tau. [PDF]

Curr Opin Neurol
Das S, Hyman BT, Serrano-Pozo A.
europepmc   +1 more source