Results 121 to 130 of about 27,856 (310)

Tauopathies, motricité et cognition [Tauopathy, motricity and cognition]

, 2023
The tauopathies are one of the families of proteinopathies causing neurodegenerative diseases. They are characterized by a combination of cognitive and motor disorders. In this article, we summarize the clinical features of progressive supranuclear palsy and cortico-basal degeneration, focusing on their cognitive-behavioral impairment profiles, which ...
Kermorvant, H., Castro-Jimenez, M., Allali, G., Bally, J.F.   +3 more
openaire   +1 more source

Reply: “PGRN Manifesting as Parkinson's Disease: Counseling and Treatment Implications”

Movement Disorders Clinical Practice, EarlyView.
Angelo Antonini, Giulia Bonato, Miryam Carecchio   +2 more
wiley   +1 more source

Tau‐targeting active immunotherapy slows progression and reduces pathology in mouse models of tauopathy

Brain Pathology, EarlyView.
The efficacy of the novel anti‐tau active immunotherapy, p5555kb, was tested using two mouse models of tau pathology. p5555kb inoculation increased the survival rate and reduced tau pathology in tau‐overexpressing P301L mice and decreased tau seeding in the brains of C57BL/6 mice injected with human‐purified Alzheimer's disease tau.
Christopher M. Brown, Jeanne K. Brooks, Louise Kelly, Madeline M. Vroom, Matthew Longo, Jean‐Cosme Dodart, Roxana Carare, Justin D. Boyd   +7 more
wiley   +1 more source

Lineage-specific splicing regulation of MAPT gene in the primate brain

Cell Genomics
Summary: Divergence of precursor messenger RNA (pre-mRNA) alternative splicing (AS) is widespread in mammals, including primates, but the underlying mechanisms and functional impact are poorly understood.
Yocelyn Recinos, Suying Bao, Xiaojian Wang, Brittany L. Phillips, Yow-Tyng Yeh, Sebastien M. Weyn-Vanhentenryck, Maurice S. Swanson, Chaolin Zhang   +7 more
doaj   +1 more source

Phosphorylation and Dephosphorylation of Tau Protein During Synthetic Torpor

Frontiers in Neuroanatomy, 2019
Tau protein is of primary importance for many physiological processes in neurons, where it affects the dynamics of the microtubule system. When hyperphosphorylated (PP-Tau), Tau monomers detach from microtubules and tend to aggregate firstly in oligomers,
Marco Luppi, Timna Hitrec, Alessia Di Cristoforo, Fabio Squarcio, Agnese Stanzani, Alessandra Occhinegro, Pierfrancesco Chiavetta, Domenico Tupone, Domenico Tupone, Giovanni Zamboni, Roberto Amici, Matteo Cerri   +11 more
doaj   +1 more source

Tau phosphorylation at Alzheimer\u27s disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated. [PDF]

, 2016
Abnormal phosphorylation of the microtubule-associated protein tau is observed in many neurodegenerative diseases, including Alzheimer\u27s disease (AD).
Ando, Kanae, Hayashishita, Motoki, Hisanaga, Shin-Ichi, Iijima, Koichi M., Ohtake, Yosuke, Oka, Mikiko, Shimizu, Sawako   +6 more
core   +1 more source

Effects of Deferasirox in Alzheimer’s Disease and Tauopathy Animal Models [PDF]

, 2022
Ping Kwan, Amy Ho, Larry Baum
openalex   +1 more source

Frontotemporal dementia: Clinical aspects, genetics, and neuropathology of a family with a C9ORF72 expansion in Argentina

Brain Pathology, EarlyView.
Immunohistochemistry for TDP‐43: (A)—Dentate gyrus; (B)—Temporal lobe. Abstract Frontotemporal dementia (FTD) is the second most common cause of early‐onset dementia, typically manifesting before the age of 65, with a mean onset at 58 years. FTD may encompass a spectrum of neurodegenerative disorders resulting from frontotemporal lobar degeneration ...
Karen Daniela Román, Carolina Agata Ardohain, Ezequiel I. Surace, Mónica Beatriz Mezmezian, Alejandro Levy, Alice Baez Lovera, Carlos Turizo, Marcos G. Sorbara, María M. Esnaola y Rojas, Gastón H. Graviotto, Gustavo Sevlever, Ricardo F. Allegri, Cecilia M. Serrano, Nahuel Magrath Guimet   +13 more
wiley   +1 more source

Screening of Tau Protein Kinase Inhibitors in a Tauopathy-relevant cell-based model of Tau Hyperphosphorylation and Oligomerization [PDF]

, 2019
Hamad Yadikar, Isabel Torres, Gabrielle Aiello, Milin Kurup, Zhihui Yang, Fan Lin, Firas Kobeissy, Richard A. Yost, Kevin Wang   +8 more
openalex   +1 more source

Beyond diabetes and obesity: GLP‐1 receptor agonists in disrupting the vicious cycle of metabolic dysfunction and neuroinflammation

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Neurodegenerative diseases, including debilitating conditions like Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, a process fundamentally driven by persistent chronic neuroinflammation and central metabolic dysfunction.
Renata Spezani, Carlos A. Mandarim‐de‐Lacerda   +1 more
wiley   +1 more source