Results 151 to 160 of about 31,353 (262)

Spatially resolved transcriptomic profiling identifies distinct signatures in parenchymal and vascular microenvironments in Alzheimer's Disease with Cerebral Amyloid Angiopathy

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) pathology frequently coexists with cerebral amyloid angiopathy (CAA), in which amyloid beta (Aβ) deposits in cerebral blood vessels. Although anti‐Aβ immunotherapies can reduce parenchymal plaques, they often exacerbate vascular pathology.
Enrique Chimal‐Juárez, Nur Jury‐Garfe, Laura Gomez‐Isaza, Juan C. Troncoso, Cristian A. Lasagna‐Reeves   +4 more
wiley   +1 more source

The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer’s disease

Drug Design, Development and Therapy, 2016
Kuo-Hsuan Chang,1,* I-Cheng Chen,1,* Hsuan-Yuan Lin,2 Hsuan-Chiang Chen,2 Chih-Hsin Lin,1 Te-Hsien Lin,2 Yu-Ting Weng,1 Chih-Ying Chao,1 Yih-Ru Wu,1 Jung-Yaw Lin,2 Guey-Jen Lee-Chen,2 Chiung-Mei Chen1 1Department of Neurology, Chang Gung Memorial ...
Chang KH, Chen IC, Lin HY, Chen HC, Lin CH, Lin TH, Weng YT, Chao CY, Wu YR, Lin JY, Lee-Chen GJ, Chen CM   +11 more
doaj  

Loss of Smek1 Induces Tauopathy and Triggers Neurodegeneration by Regulating Microtubule Stability

Advanced Science
Suppressor of Mek1 (Smek1) is a regulatory subunit of protein phosphatase 4. Genome‐wide association studies have shown the protective effect of SMEK1 in Alzheimer's disease (AD). However, the physiological and pathological roles of Smek1 in AD and other
Ruo‐Nan Duan, Ai Liu, Yue‐Qing Sun, Yun‐Fang Xie, Shi‐Jun Wei, Shang Gao, Yi‐Ming Liu, Xi Li, Wen‐Jie Sun, Jiang‐Xia Li, Chuan‐Zhu Yan, Qi‐Ji Liu   +11 more
doaj   +1 more source

New Compounds From the Deep‐sea Sponge Mycale lingua

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
The focus of this study is the scarcely investigated sponge Mycale lingua, found commonly in the North Atlantic Ocean. In total, four compounds are isolated and characterised from three combined M. lingua individuals. Structures are fully elucidated through HR‐LCMS and NMR spectroscopy (1H, COSY, HSQC, HMBC).
H. Poppy Clark, David Horsley, Amanda Serpell‐Stevens, Tammy Horton, Ann I. Larsson, Emmanuel Tope Oluwabusola, Rainer Ebel, Laurence H. De Clippele, Marcel Jaspars   +8 more
wiley   +1 more source

Noninvasive imaging of amyloid‐beta and tau in rodent and nonhuman primate models

VIEW, Volume 7, Issue 1, February 2026.
Imaging of amyloid‐beta plaque and tau accumulation in rodent and nonhuman primate model of Alzheimer's disease. Created in BioRender. Ni R. 2026. https://BioRender.com/a97h5ec Abstract Neurodegenerative diseases are characterized by the aberrant accumulation of protein aggregates.
Ruiqing Ni, Axel Rominger
wiley   +1 more source

Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice

Aging Cell, Volume 25, Issue 2, February 2026.
Comprehensive transcriptomic profiling of eight mouse organs across six ages reveals how aging reshapes biological processes. Trajectory and network analyses distinguish shared and organ‐specific signatures, charting the molecular landscape of systemic aging.
Sarah Morsy, Enzo Scifo, Kan Xie, Kristina Schaaf, Jenny Russ, Stefan Paulusch, Elena De Domenico, Paolo Salomoni, Daniele Bano, Dan Ehninger   +9 more
wiley   +1 more source

The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review

The Journal of Physiology, Volume 604, Issue 4, Page 1646-1681, 15 February 2026.
Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker, Andrew F. James, Svetlana Mastitskaya   +2 more
wiley   +1 more source

Defining patient-centered amyloid PET thresholds for the onset of tauopathy in Alzheimer's disease. [PDF]

Alzheimers Dement
Zhu Z, Steward A, Dehsarvi A, Roemer-Cassiano SN, Dewenter A, Biel D, Hirsch F, Frontzkowski L, Pescoller J, Klonowski M, Gnörich J, Pontecorvo MJ, Shcherbinin S, Schöll M, Buckley R, Ossenkoppele R, Xie F, Guo T, Alzheimer's Disease Neuroimaging Initiative, Höglinger G, Brendel M, Franzmeier N.   +21 more
europepmc   +1 more source

Spilling the T: T cells in tauopathy mechanisms, disease progression, and therapeutic horizons. [PDF]

Mol Neurodegener Adv
Bosch ME, Ulrich JD.
europepmc   +1 more source

The Tauopathies [PDF]

The American Journal of Pathology, 1999
Michel Goedert, Masato Hasegawa
openaire   +1 more source