Results 71 to 80 of about 2,522,698 (156)

Major Depressive Disorder Signatures: A Review of Artificial Intelligence (AI)‐Powered Insights Into Gut Dysbiosis

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Major Depressive Disorder (MDD) is a highly common neuropsychiatric disorder globally. A variety of factors contribute to the neuropathology of MDD. Microbiome research in neuropsychiatric disorders such as MDD has recently attracted attention. Indeed, the gut‐brain axis could influence the course of MDD through metabolites
Nazanin Zahra Keshvari, Sara Asl Motaleb Nejad Sarkhab, Tara Shahmoradi, Mohammad Pourashory, Arash Esmaeili, Kiarash Saleki, Nima Rezaei   +6 more
wiley   +1 more source

CHARACTERIZATION OF TRANSPORT IN ISOLATED HUMAN HEPATOCYTES - A STUDY WITH THE BILE-ACID TAUROCHOLIC ACID, THE UNCHARGED OUABAIN AND THE ORGANIC CATIONS VECURONIUM AND ROCURONIUM

, 1994
The uptake and efflux of three categories of substrates were measured in isolated human hepatocytes and compared to those in rat hepatocytes. In addition, the extent to which the in vitro experiments quantitatively reflect liver function in vivo in both ...
GROOTHUIS, GMM, MEIJER, DKF, SANDKER, GW, OLINGA, P; id_orcid, WEERT, B, WOLTERS, H, SLOOFF, MJH   +6 more
core   +1 more source

Bile acid and bile salt disrupt gastric mucosal barrier in the dog by different mechanisms

, 1982
The present study was undertaken to assess the mechanism by which protonated taurocholic acid disrupts the gastric mucosal barrier. By the criterion of lecithin solubilization, the critical micellar concentration of taurocholic acid (pH 1) was 4.5 mM ...
D. M. Wiegand, C. E. Sievert, W. C. Duane   +2 more
core   +1 more source

Bile acid metabolism and signaling in human and animal health: A One Health perspective

iMetaOmics, Volume 3, Issue 3, September 2026.
Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li, Shuai Liu, Zhijun Cao, Yangchun Cao, Shengru Wu, Lu Deng, Junhu Yao, Jun Zhang   +7 more
wiley   +1 more source

In Vitro Modeling of Bile Acid Processing by the Human Fecal Microbiota

Frontiers in Microbiology, 2018
Bile acids, the products of concerted host and gut bacterial metabolism, have important signaling functions within the mammalian metabolic system and a key role in digestion.
Glynn Martin, Sofia Kolida, Julian R. Marchesi, Julian R. Marchesi, Julian R. Marchesi, Elizabeth Want, James E. Sidaway, Jonathan R. Swann   +7 more
doaj   +1 more source

Allylic oxidation of ent-Kaurenic acid, ent-Kaurenic acid Methyl Ester and ent-Kaurenol. [PDF]

, 2015
The allylic oxidation of ent-kaurenic acid, ent-kaurenic acid methyl ester, and ent-kaurenol with SeO2/H2O2 is presented. The reaction was run in dioxan solution at room temperature stirring for 4 hours.
Bahsas B., Alí H., Usubillaga, Alfredo, Aparicio Z., Rosa L.   +2 more
core   +1 more source

Human‐Centered Innovation: Precision Nutrition and the Future of Food

Advanced Science, Volume 13, Issue 44, 7 August 2026.
ABSTRACT Nutritional science is moving beyond one‐size‐fits‐all recommendations toward more precise and personalized approaches, yet its implementation pathway remains unclear. This paper proposes a human‐centered precision nutrition framework that highlights the central roles of artificial intelligence (AI), food innovation, and human agency.
Shanshan Zhang, Yonggan Sun, Jiaqi Jiang, Shaoping Nie   +3 more
wiley   +1 more source

Taurocholic acid feeding prevents tumor necrosis factor-alpha-induced damage of cholangiocytes by a PI3K-mediated pathway.

, 2007
Cholangiopathies, such as primary biliary cirrhosis and primary sclerosis cholangitis, are characterized at the end stage by ductopenia due to increased cholangiocyte apoptosis and decreased cholangiocyte proliferation.
G. Alpini, G. Fava, J. Venter, Y. Ueno, H. Francis, S. Glaser, S. Demorrow, MARZIONI, MARCO, BENEDETTI, Antonio   +8 more
core  

Momordica charantia Ethanol Extract Alleviates Type 2 Diabetes Mellitus Through Gut Microbiota‐Derived Tryptophan Metabolism

Food Frontiers, Volume 7, Issue 4, July 2026.
ABSTRACT Type 2 diabetes mellitus (T2DM) poses a significant global public health challenge. Dietary interventions rich in plant extracts of bioactive substances show promise for alleviating the symptoms of Type 2 diabetes. Previous studies have reported the excellent efficiency of Momordica charantia L.
Qiaojun Huang, Ziqing Liang, Yanting Zeng, Chenyan Yao, Jingtong He, Yong Cao, Yunjiao Chen   +6 more
wiley   +1 more source

The Enhanced Anti-anxiety Potentiality and Relevant Material Basis for the Extracts of Bile Processed Coptidis Rhizoma

Natural Product Communications
Objective Bile-processed Coptidis Rhizoma (CR) exhibits stronger cold properties and central effect. However, the commonly used bile includes pig/cattle/sheep bile.
Long Chen, Ruifeng Wang, Lin Chen, Zhenkai Zhang, Bingxian Zhang, Yongxiang Wang, Weisheng Feng, Xiaoke Zheng, Kai Li, Ning Zhou   +9 more
doaj   +1 more source