Results 71 to 80 of about 6,842 (160)

SIRT5–RAC2 Axis Drives Monocyte‐to‐Macrophage Differentiation to Promote Inflammatory Injury in Premature Ovarian Insufficiency

Advanced Science, Volume 13, Issue 14, 9 March 2026.
SIRT5 desuccinylates and stabilizes RAC2, activating CSF1R‐dependent signaling to drive monocyte differentiation into M0 macrophages and their polarization toward pro‐inflammatory M1 phenotypes in CTX‐induced premature ovarian insufficiency. Inhibiting the SIRT5‐RAC2 axis attenuates inflammation, reduces granulosa cell apoptosis, and preserves ...
Wenjing TanTai, Yaqi Li, Shengnan Liu, Minjuan Wu, Zhixiao Liu, Junfeng Jiang, Jingjing Chen, Xiaoding Xu, Li Li, Chaoqun Li, Fang Zhao, Ye Liu, Haitao Ni, Tengfei Zhang, Mingjuan Xu, Chaofeng Han   +15 more
wiley   +1 more source

Effect of Nicotinic Acid on Pool Size and Turnover of Taurocholic Acid in Normal and Hypothyroid Dogs.

Experimental Biology and Medicine, 1966
SummaryThe rate of disappearance of taurocholic-14C acid from bile was studied in a group of dogs after oral administration of cholic-carboxyl-14C acid. The specific activity of taurocholic acid was determined in multiple small samples of bile by quantitative thin-layer chromatography and liquid scintillation counting; biologic half-life, pool size ...
J, Wollenweber, B A, Kottke, C A, Owen
openaire   +2 more sources

Bile acids are associated with baseline and longitudinal amyloid and tau pathology in patients with Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Alzheimer's disease (AD), a neurodegenerative disease, involves early alterations in the gut microbiota. Bile acids (BAs), which are metabolites produced by the microbiota, may impact brain function through the gut‐brain axis. METHODS By reference to multimodal datasets from the Chinese Preclinical Alzheimer's Disease Study (n ...
Wenjie Fu, Xiaowen Chao, Ying Wang, Shu Liu, Jie Wang, Qi Huang, Ying Luan, Peiyang Luo, Yihui Guan, Yingren Mai, Wei Jia, the Alzheimer's Disease Neuroimaging Initiative, Qihao Guo, Tianlu Chen, Xiaowei Ma, Fang Xie   +15 more
wiley   +1 more source

Schisantherin A: Remodeling Gut Microbiota to Activate the Gut–Immune–Neural–Adipose Axis for Thermogenesis

iNew Medicine, Volume 2, Issue 1, March 2026.
ABSTRACT The global obesity epidemic necessitates safe and effective strategies to enhance energy expenditure. Schisantherin A (Sin A), a lignan derived from Schisandra chinensis, has demonstrated metabolic benefits, yet its systemic mechanism remains unclear.
Ling Yin
wiley   +1 more source

The Enhanced Anti-anxiety Potentiality and Relevant Material Basis for the Extracts of Bile Processed Coptidis Rhizoma

Natural Product Communications
Objective Bile-processed Coptidis Rhizoma (CR) exhibits stronger cold properties and central effect. However, the commonly used bile includes pig/cattle/sheep bile.
Long Chen, Ruifeng Wang, Lin Chen, Zhenkai Zhang, Bingxian Zhang, Yongxiang Wang, Weisheng Feng, Xiaoke Zheng, Kai Li, Ning Zhou   +9 more
doaj   +1 more source

Effect of sodium taurocholate on the human gastric mucosa at acid and neutral pH's

Gastroenterology, 1984
This study was conducted to determine whether taurocholate alters human gastric function and structure at a neutral pH, when ionized, and to contrast this with its effect at an acid intraluminal pH, when pronated. Five fasted healthy subjects were studied on 4 days in random order.
A I, Stern, D L, Hogan, J I, Isenberg
openaire   +2 more sources

Cholesterol-Lowering Activity of the Major Polyphenols in Grape Seed

Molecules, 2011
The major polyphenols in grape seed have been shown to have beneficial health effects in the prevention of dyslipidemia and cardiovascular diseases. In this present study, we investigated the cholesterol-lowering activity of three major polyphenolic ...
Sirichai Adisakwattana, Thavaree Thilawech, Kittana Mäkynen, Sathaporn Ngamukote   +3 more
doaj   +1 more source

Effects of dietary cholesterol and hypothyroidism on rat apolipoprotein mRNA metabolism.

Journal of Lipid Research, 1987
The effects of dietary cholesterol and hypothyroidism on the mRNA levels of rat apolipoproteins A-I, A-IV, and E were measured in extracts of rat liver and rat intestine by hybridization to specific cDNA. Four groups, each comprised of six rats, were fed
J J Apostolopoulos, G J Howlett, N Fidge
doaj   +1 more source

Taurocholic acid-induced secretion in normal and cystic fibrosis mouse ileum

Journal of Pharmacy and Pharmacology, 2001
Abstract Bile acids cause secretion throughout the intestinal tract and this process contributes to maintaining the fluidity of intestinal contents. In cystic fibrosis (CF) defective intestinal secretion can lead to excessive dehydration of the luminal contents and the development of clinical symptoms.
J, Hardcastle, P T, Hardcastle, J, Chapman, C J, Taylor   +3 more
openaire   +2 more sources

The Effect of Sodium Benzoate and Taurocholic Acid Feeding on Human Bile Composition

Experimental Biology and Medicine, 1975
Four patients were fed sodium benzoate after stabilization following common bile duct exploration. Bile collections revealed no change in the output of glycine conjugated bile acids. Three patients had taurocholic acid added to the regimen after 3 days and demonstrated a significant increase in total and taurine conjugated bile acid output with marked ...
C, Dennis, B, Gardner, J, Patti, M, Chenouda   +3 more
openaire   +2 more sources