Results 61 to 70 of about 6,842 (160)

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, Volume 15, Issue 17, 8 May 2026.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Conjugated 2′‐Fucosyllactose–Potato Protein Hydrolysate as Novel Prebiotics

Food Frontiers, Volume 7, Issue 3, May 2026.
This study introduces a novel protein‐containing prebiotic based on 2′‐FL‐PPH Maillard conjugates micelles that co‐deliver proteins and carbohydrates to the colon to selectively nourish colonic probiotics. These digestion‐resistant micelles enhanced Bifidobacteria, SCFAs, gut barrier integrity, and metabolic health more effectively than conventional ...
Stav Peled, May Cohen‐Hakmon, Ravit Edelman, Yechezkel Kashi, Yoav D. Livney   +4 more
wiley   +1 more source

Development and Transportation Pathway Evaluation of Liposomes with Bile Acids for Enhancing the Blood-Brain Barrier Penetration of Methotrexate

Pharmaceutics
Background/Objectives: The purpose of this study was to create bile acid-containing liposomes to improve methotrexate blood-brain barrier penetration and to assess the liposome transportation mechanism across the blood–brain barrier.
Natthan Charernsriwilaiwat, Rattanan Thaitrong, Samarwadee Plianwong, Praneet Opanasopit, Pucharee Songprakhon, Thirapit Subongkot   +5 more
doaj   +1 more source

Bile Acid Regulates Mononuclear Phagocytes and T Helper 17 Cells to Control Candida albicans in the Intestine

Journal of Fungi, 2022
Invasive Candida albicans (CA) infections often arise from the intestine and cause life-threatening infections in immunocompromised individuals. The role of gut commensal microbiota, metabolites, and host factors in the regulation of CA colonization in ...
Abhishek Datta, Juan F. Hernandez-Franco, Sungtae Park, Matthew R. Olson, Harm HogenEsch, Shankar Thangamani   +5 more
doaj   +1 more source

A Triterpenoid‐Enriched GLE70 Fraction From Ganoderma lingzhi Ameliorates Alcoholic Liver Disease via Multi‐Target Regulation

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
GLE fractions were prepared from Ganoderma lingzhi using gradient ethanol elution and evaluated for their biological activities. Among the fractions, GLE70 exhibited the strongest antioxidant and hepatoprotective effects. Integrated chemical characterization, network pharmacology, molecular docking, and in vivo validation suggested that GLE70 may exert
Yanjun Chen, Wenjia Li, Shiyi Ye, Jiaxue Li, Xiaobing Song, Qianli Ma, Ping Chen, Biying Zhang   +7 more
wiley   +1 more source

Transparent UV‐Curable Self‐Sanitizing Coatings Applicable to Diverse Surfaces and High‐Touch Screens to Mitigate Deadly Pathogen Transmission

Advanced Functional Materials, Volume 36, Issue 35, 30 April 2026.
Development of a transparent, self‐sanitizing antimicrobial coating technology applicable to a wide range of materials and surfaces‐including touchscreens, transparent substrates, and metal, plastic, and glass‐regardless of pathogen type. The spray‐coated, UV‐cross‐linked imidazole‐based quaternary ammonium chloride materials provide broad‐spectrum ...
Surjith Kumaran, Sumin Han, Euna Oh, Chunghee Jo, Hyerin Shin, Dae‐Hong Ko, Hyo‐Jick Choi   +6 more
wiley   +1 more source

Exposure to Microcystin-LR Promotes Colorectal Cancer Progression by Altering Gut Microbiota and Associated Metabolites in APC^min/+ Mice

Toxins
Microcystins (MCs), toxins generated by cyanobacteria, feature microcystin-LR (MC-LR) as one of the most prevalent and toxic variants in aquatic environments.
Yuechi Song, Xiaochang Wang, Xiaohui Lu, Ting Wang   +3 more
doaj   +1 more source

Chondroitin sulfate restores muscle mass via gut–muscle axis remodeling through sugar–bile acid metabolism reprogramming

iMeta, Volume 5, Issue 2, April 2026.
The graphical abstract illustrates the molecular mechanism by which chondroitin sulfate (DCS) alleviates glucocorticoid‐induced myopathy through the gut–muscle axis. DCS selectively enriches L. johnsonii Z‐RW, enhancing bshA‐encoded BSH activity to promote bile acid deconjugation and reduce the sugar–bile acid ratio, thereby re‐establishing intestinal ...
Ruiyun Wu, Tao Wen, Nan Shang, Penghao Xie, Zhenyu Wang, Hang Li, Shaobo Li, Dequan Zhang   +7 more
wiley   +1 more source

N-Acetylcysteine Improves Pancreatic Microcirculation and Alleviates the Severity of Acute Necrotizing Pancreatitis

Gut and Liver, 2013
Background/AimsTo investigate the beneficial effect of N-Acetylcysteine (NAC) on pancreatic microvascular perfusion in acute necrotizing pancreatitis (ANP).Methods : Fifty-four rats were divided into a control group, an ANP group and an NAC-treated group.
doaj   +1 more source

In Vitro Modeling of Bile Acid Processing by the Human Fecal Microbiota

Frontiers in Microbiology, 2018
Bile acids, the products of concerted host and gut bacterial metabolism, have important signaling functions within the mammalian metabolic system and a key role in digestion.
Glynn Martin, Sofia Kolida, Julian R. Marchesi, Julian R. Marchesi, Julian R. Marchesi, Elizabeth Want, James E. Sidaway, Jonathan R. Swann   +7 more
doaj   +1 more source