Results 61 to 70 of about 2,522,698 (156)

Human and rat precision-cut intestinal slices as ex vivo models to study bile acid uptake by the apical sodium-dependent bile acid transporter [PDF]

, 2018
The apical sodium-dependent bile acid transporter (ASBT) is the primary transporter for the uptake of bile acids in the small intestine. It is localized on the apical membrane of the ileal enterocytes and is known for its high capacity and affinity for ...
Li, Ming, Ming Li, Evers, Bernard; id_orcid, Evers, Bernard, Ivan Vokral, Marina H. de Jager, Vokral, Ivan, Geny M.M. Groothuis, Bernard Evers, de Graaf, Inge A. M., Groothuis, Geny M. M., de Jager, Marina H., Inge A.M. de Graaf   +12 more
core   +2 more sources

MALDI imaging MS reveals candidate lipid markers of polycystic kidney disease[S]

Journal of Lipid Research, 2013
Autosomal recessive polycystic kidney disease (ARPKD) is a severe, monogenetically inherited kidney and liver disease. PCK rats carrying the orthologous mutant gene serve as a model of human disease, and alterations in lipid profiles in PCK rats suggest ...
Hermelindis Ruh, Theresia Salonikios, Jens Fuchser, Matthias Schwartz, Carsten Sticht, Christina Hochheim, Bernhard Wirnitzer, Norbert Gretz, Carsten Hopf   +8 more
doaj   +1 more source

Nanomedicine for the Treatment of Pediatric Type 2 Diabetes: Progress, Challenges, and Translational Perspectives

Advanced Therapeutics, Volume 9, Issue 9, September 2026.
Overview of pharmaceutical nanocarriers in diabetes, illustrating applications of nanotechnology including enhanced drug and targeted drug delivery and nanosensors for glucose monitoring and diagnosis. ABSTRACT Pediatric type 2 diabetes mellitus (T2DM) is rapidly emerging as a critical global health concern, driven largely by rising childhood obesity ...
Nnamdi Ikemefuna Okafor, Bukosi Baloyi, Yahya E. Choonara   +2 more
wiley   +1 more source

Signal transduction for taurocholic acid in the olfactory system of atlantic salmon

, 1994
Conjugated bile acids such as taurocholic acid (TChA) are potent olfactory stimuli for Atlantic salmon (Salmo solar). A plasma membrane rich fraction was derived from salmon olfactory rosettes and used to investigate TChA signal transduction and receptor
Rhoads, Dennis E., Lo, Ying Har, Bradley, Terence M., Pang, Jiongdong, Cheng, Lee Ju, Bellis, Susan L.   +5 more
core   +1 more source

FXR‐Mediated Atherosclerosis Alleviation by B. animalis F1‐7 Through Bile Acid Metabolism‐Driven Gut–Liver Axis Modulation

Food Frontiers
This study investigates the mechanisms of B. animalis F1‐7 improving atherosclerosis (AS) through bile acid metabolism by using an “antibiotic cocktail” approach in AS model mice. It was found that B.
Tianhu Shan, Jiawen Wang, Yanyang Liu, Huaqi Zhang, Zhe Zhang, Lanwei Zhang, Hui Liang, Xi Liang   +7 more
doaj   +1 more source

N-Acetylcysteine Improves Pancreatic Microcirculation and Alleviates the Severity of Acute Necrotizing Pancreatitis

Gut and Liver, 2013
Background/AimsTo investigate the beneficial effect of N-Acetylcysteine (NAC) on pancreatic microvascular perfusion in acute necrotizing pancreatitis (ANP).Methods : Fifty-four rats were divided into a control group, an ANP group and an NAC-treated group.
doaj   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, Volume 13, Issue 54, 28 September 2026.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Differential Disposition of Chenodeoxycholic Acid versus Taurocholic Acid in Response to Acute Troglitazone Exposure in Rat Hepatocytes [PDF]

, 2011
Inhibition of bile acid (BA) transport may contribute to the hepatotoxicity of troglitazone (TRO), a peroxisome proliferator–activated receptor gamma agonist.
Tracy L. Marion, Marion, Tracy L., Kim L. R. Brouwer, Perry, Cassandra H., St. Claire, Robert L., Yue, Wei, Wei Yue, Robert L. St. Claire, Cassandra H. Perry, Brouwer, Kim L. R.   +9 more
core   +1 more source

Taurine and Metabolic Diseases: Molecular Mechanisms and Therapeutic Implications

Food Frontiers, Volume 7, Issue 5, September 2026.
The dietary sources of taurine, as well as its protective effects and mechanisms in metabolism‐related diseases and metabolic disorder–associated ocular and cerebral injuries. ABSTRACT Taurine (Tau) is a sulfur‐containing amino acid prevalent in animal tissues and primarily acquired through dietary sources.
Xiaojie Ma, Zhijian Rao, Lifang Zheng
wiley   +1 more source

Exposure to Microcystin-LR Promotes Colorectal Cancer Progression by Altering Gut Microbiota and Associated Metabolites in APC^min/+ Mice

Toxins
Microcystins (MCs), toxins generated by cyanobacteria, feature microcystin-LR (MC-LR) as one of the most prevalent and toxic variants in aquatic environments.
Yuechi Song, Xiaochang Wang, Xiaohui Lu, Ting Wang   +3 more
doaj   +1 more source