Results 61 to 70 of about 6,894 (164)

Phytochemicals in MASLD: A Focused Review of Gut Microbiome‐Linked Mechanisms

Phytotherapy Research, Volume 40, Issue 7, Page 4041-4055, July 2026.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as a major global health burden, yet effective pharmacological options remain limited. Recent advances highlight the gut microbiome as a key modulator of liver metabolism, inflammation, and fibrosis, making it a promising therapeutic target.
Jeong In Seo, Su Min Kim, Hye Hyun Yoo
wiley   +1 more source

Dysregulated Metabolism in People Living With HIV in the Modern ART‐Era: A Systematic Review of Targeted Metabolomics Studies

Reviews in Medical Virology, Volume 36, Issue 4, July 2026.
ABSTRACT HIV remains a significant public health issue, with 1.3 million new infections and 630,000 deaths annually, and 40.8 million people living with HIV (PLHIV) globally in 2024. Although antiretroviral therapy (ART) suppresses viral replication, it does not eradicate the virus, and metabolic dysregulation persists despite treatment.
Levanco K. Asia, Du Toit Loots, Shayne Mason, Esme Jansen Van Vuren, Monray E. Williams   +4 more
wiley   +1 more source

Liver‐ and Immune‐Enriched Molecular Signatures Associated With Mortality in Older Adults

Aging Cell, Volume 25, Issue 7, July 2026.
Untargeted plasma proteomics and metabolomics identified molecular signatures associated with all‐cause mortality in older adults. A liver‐enriched proteomic profile was associated with mortality risk in the ILAS cohort and showed consistent associations in an independent validation cohort, supporting circulating proteomic profiles for mortality risk ...
Yi‐Long Huang, Wei‐Ju Lee, Pei‐Lin Lee, Li‐Ning Peng, Fei‐Yuan Hsiao, Liang‐Kung Chen   +5 more
wiley   +1 more source

Insights Into Gut Microbiota and Metabolic Alterations in Type 1 Diabetes Mellitus

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
Caroline Fogagnolo, Gabriela Ueta Ortiz, Adelino Sanchez Ramos da Silva, Ellen Cristini de Freitas   +3 more
wiley   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, Volume 13, Issue 34, 19 June 2026.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

The Enhanced Anti-anxiety Potentiality and Relevant Material Basis for the Extracts of Bile Processed Coptidis Rhizoma

Natural Product Communications
Objective Bile-processed Coptidis Rhizoma (CR) exhibits stronger cold properties and central effect. However, the commonly used bile includes pig/cattle/sheep bile.
Long Chen, Ruifeng Wang, Lin Chen, Zhenkai Zhang, Bingxian Zhang, Yongxiang Wang, Weisheng Feng, Xiaoke Zheng, Kai Li, Ning Zhou   +9 more
doaj   +1 more source

Effect of sodium taurocholate on the human gastric mucosa at acid and neutral pH's

Gastroenterology, 1984
This study was conducted to determine whether taurocholate alters human gastric function and structure at a neutral pH, when ionized, and to contrast this with its effect at an acid intraluminal pH, when pronated. Five fasted healthy subjects were studied on 4 days in random order.
A I, Stern, D L, Hogan, J I, Isenberg
openaire   +2 more sources

Cholesterol-Lowering Activity of the Major Polyphenols in Grape Seed

Molecules, 2011
The major polyphenols in grape seed have been shown to have beneficial health effects in the prevention of dyslipidemia and cardiovascular diseases. In this present study, we investigated the cholesterol-lowering activity of three major polyphenolic ...
Sirichai Adisakwattana, Thavaree Thilawech, Kittana Mäkynen, Sathaporn Ngamukote   +3 more
doaj   +1 more source

Taurocholic acid-induced secretion in normal and cystic fibrosis mouse ileum

Journal of Pharmacy and Pharmacology, 2001
Abstract Bile acids cause secretion throughout the intestinal tract and this process contributes to maintaining the fluidity of intestinal contents. In cystic fibrosis (CF) defective intestinal secretion can lead to excessive dehydration of the luminal contents and the development of clinical symptoms.
J, Hardcastle, P T, Hardcastle, J, Chapman, C J, Taylor   +3 more
openaire   +2 more sources

Effects of dietary cholesterol and hypothyroidism on rat apolipoprotein mRNA metabolism.

Journal of Lipid Research, 1987
The effects of dietary cholesterol and hypothyroidism on the mRNA levels of rat apolipoproteins A-I, A-IV, and E were measured in extracts of rat liver and rat intestine by hybridization to specific cDNA. Four groups, each comprised of six rats, were fed
J J Apostolopoulos, G J Howlett, N Fidge
doaj   +1 more source